There are currently 21 active clinical trials seeking participants for Liver Diseases research studies. The states with the highest number of trials for Liver Diseases participants are California, Florida, Texas and New York.
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California +105 locations
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
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Genetic Collection Protocol
NCT05272319
Recruiting
This study involves the one-time collection of whole blood or saliva samples for the extraction and storage of DNA for use in ongoing and future ChiLDReN studies.
Gender:
ALL
Ages:
Between 24 hours and 25 years
Trial Updated:
07/30/2024
Locations: Children's Hospital of Los Angeles, Los Angeles, California +12 locations
Conditions: Liver Diseases
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Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase
NCT06278883
Recruiting
The "Genomic medicine Risk Assessment Care for Everyone" (GRACE)" intervention project will develop a scalable end-to-end solution for risk assessment and management that meets the needs of those populations living in low resource settings. The long-term goal is to increase access to and uptake of risk-informed evidence-based guidelines that will improve population health through better patient outcomes, higher quality of life, and decreased costs. The three primary aims are: Aim 1: Develop a s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: UF Health Callahan, Callahan, Florida +4 locations
Conditions: Cardiovascular Diseases, Cancer, Liver Diseases, Hyperthermia
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A Research Study on Etavopivat in Participants With and Without Liver Disease
NCT06336018
Recruiting
The study investigates an investigational drug called etavopivat in participants with hepatic impairments and participants with normal hepatic function (matched controls). During the study, all participants will be given a single oral dose of etavopivat. All participants will take the etavopivat orally together with water. After dosing, the study will last for 7 to 9 days.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/10/2024
Locations: Orlando Clinical Research Center, Orlando, Florida +1 locations
Conditions: Liver Diseases
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Primary Sclerosing Cholangitis in Children
NCT04181138
Recruiting
Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver's bile ducts. Bile ducts are tiny tubes that carry bile from the liver to the small intestine. Bile is a liquid produced by the liver that helps us absorb and use the nutrients in the food we eat. In people with PSC, the bile backs up into the liver and will damage it, causing scarring of the liver. The purposes of this study are to: Collect medical and other data to learn more about PSC, how it progresses, and... Read More
Gender:
All
Ages:
Between 2 years and 25 years
Trial Updated:
06/04/2024
Locations: Children's Hospital of Los Angeles, Los Angeles, California +11 locations
Conditions: Primary Sclerosing Cholangitis, Liver Diseases, Cholangitis, Sclerosing
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DILIN - Prospective Study
NCT00345930
Recruiting
The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine. Recently added acute cases enrollment that meets criteria to the protocol. Also added Fibroscans to the protocol that will be completed at baseline and follow-up on chronic subjects.
Gender:
All
Ages:
2 years and above
Trial Updated:
04/02/2024
Locations: University of Southern California, Los Angeles, California +6 locations
Conditions: Liver Diseases
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Safety and Efficacy of Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement
NCT06336850
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and adequacy of Endoscopic Ultrasound (EUS) Portal Pressure Gradient Measurement (PPGM) in patients undergoing EUS-guided liver biopsies.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/26/2024
Locations: Methodist Dallas Medical Center, Dallas, Texas
Conditions: Liver Diseases
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Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
NCT05191446
Recruiting
The study consists of a randomized controlled trial evaluating the efficacy and feasibility of a stepped alcohol treatment using telemedicine on unhealthy alcohol use in patients with chronic liver disease receiving care in hepatology practices at three sites. Patients who meet eligibility criteria will be randomized to one of two study arms: 1) Stepped Alcohol Treatment (SAT) or, 2) Usual Care (UC). Participants will be randomized separately by site. SAT includes 3 sessions of motivational inte... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: University of california San Francisco, San Francisco, California +1 locations
Conditions: Liver Diseases, Alcohol Use Disorder
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Blood Collection for Development and Validation of Point-of-Care Diagnostic Liver Function Tests
NCT05457543
Recruiting
This is an observational study exploring the performance of a novel point-of-care diagnostic testing platform designed to quantitate the presence of liver function biomarkers such as bilirubin. Blood samples will be collected from participants to further development and validation of the testing platform to support FDA review. The diagnostic device is intended to provide rapid in-office test results using a finger stick of blood, a reaction test device, and a smartphone app.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/11/2022
Locations: Group K Diagnostics, Philadelphia, Pennsylvania
Conditions: Liver Diseases, Healthy, Liver Cirrhosis, Liver Fibrosis
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