There are currently 23 active clinical trials seeking participants for Liver Diseases research studies. The states with the highest number of trials for Liver Diseases participants are California, Florida, Texas and New York.
Implementation of a Digital Clinic for Alcohol-associated Liver Disease and Alcohol Use Disorder (DALC)
NCT06319222
Recruiting
The purpose of this study is to determine whether a multidisciplinary digital clinic will improve health outcomes, reduce costs, increase access, and improve provider satisfaction. The primary aim of this study is to improve clinical outcomes in patients with ALD through the implementation of a novel digital health platform for personalized multi-disciplinary treatment of patients with ALD and AUD. Secondary aims include improvement in provider and patient-reported outcomes including satisfacti... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Mayo Clinic Arizona, Scottsdale, Arizona +1 locations
Conditions: Alcohol Use Disorder, Liver Diseases
Register for Updates
Safety and Efficacy of Endoscopic Ultrasound-Guided Portal Pressure Gradient Measurement
NCT06336850
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and adequacy of Endoscopic Ultrasound (EUS) Portal Pressure Gradient Measurement (PPGM) in patients undergoing EUS-guided liver biopsies.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/26/2024
Locations: Methodist Dallas Medical Center, Dallas, Texas
Conditions: Liver Diseases
Register for Updates
Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
NCT05191446
Recruiting
The study consists of a randomized controlled trial evaluating the efficacy and feasibility of a stepped alcohol treatment using telemedicine on unhealthy alcohol use in patients with chronic liver disease receiving care in hepatology practices at three sites. Patients who meet eligibility criteria will be randomized to one of two study arms: 1) Stepped Alcohol Treatment (SAT) or, 2) Usual Care (UC). Participants will be randomized separately by site. SAT includes 3 sessions of motivational inte... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: University of california San Francisco, San Francisco, California +1 locations
Conditions: Liver Diseases, Alcohol Use Disorder
Register for Updates
An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection
NCT03692897
Recruiting
The TARGET-HBV study engages an observational research design to conduct a comprehensive review of outcomes for patients with CHB infection. The initial phase of the study that enrolled patients treated with tenofovir alafenamide (TAF) was successfully completed. The current protocol (Amendment 1) describes the second phase of the study that will engage research activities for patients being managed for CHB in usual clinical practice in the US and Canada. The study addresses important clinical q... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/13/2023
Locations: Banner University Medical Center Phoenix, Phoenix, Arizona +30 locations
Conditions: Hepatitis B, Hepatitis, Liver Diseases
Register for Updates
Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
NCT05470205
Recruiting
This is an open-label, non-randomized trial that will be conducted at three clinical sites, Thomas Jefferson University (TJU), the Hospital of the University of Pennsylvania (HUP) and University of Bern (UB). Enrollment will be allocated into one of 4 different cohorts depending on the inclusion criteria for each cohort. Cohort 1: Patients scheduled for hepatic vein pressure gradient (HVPG) measurements will subsequently undergo two consecutive SHAPE (subharmonic aided pressure estimation) pro... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +2 locations
Conditions: Liver Diseases, Portal Hypertension
Register for Updates
Social & Contextual Impact on Children Undergoing Liver Transplantation
NCT04551742
Recruiting
The social determinants of health have a large impact on health. For example, neighborhood socioeconomic deprivation is associated with increased risk of medication non-adherence, graft failure, and death in children after liver transplant. In order to address these socioeconomic inequities in outcomes, a more granular understanding of how the social determinants of health impact outcomes is needed. In this observational prospective cohort, caregivers of children undergoing liver transplantation... Read More
Gender:
All
Ages:
70 years and below
Trial Updated:
06/26/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California +7 locations
Conditions: Liver Transplantation, Liver Diseases
Register for Updates
Treating Pediatric NAFLD With Nutrition
NCT05499585
Recruiting
This is a proof of concept clinical trial to compare daily intake of at least 20 grams of whole dairy fat vs habitual diet on hepatic steatosis in children with NAFLD.
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
06/01/2023
Locations: UC San Diego, La Jolla, California
Conditions: Non-Alcoholic Fatty Liver Disease, Liver Diseases, Liver Fat, Hepatic Steatosis, Nutritional and Metabolic Disease
Register for Updates
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/03/2023
Locations: Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California +105 locations
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
Register for Updates
MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease
NCT05264051
Recruiting
The purpose of the study is to study the muscle assessment score (MAsS, utilizing MRI, as an objective measure of frailty and muscle composition to serve as a predictor of morbidity and mortality in patients with liver disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/27/2023
Locations: The University of Chicago, Chicago, Illinois
Conditions: Liver Diseases
Register for Updates
Observational Pharmaco-Epidemiology Research & Analysis
NCT03813862
Recruiting
Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provider-patient encounter that support realworld medical research and healthcare quality measure assessment. Real-world evaluations of treatments of chronic diseases in the context of comorbid conditions and... Read More
Gender:
All
Ages:
0 years and above
Trial Updated:
02/14/2023
Locations: Epividian, Durham, North Carolina
Conditions: Chronic Disease, HIV/AIDS, Liver Diseases, Inflammatory Bowel Diseases, Cardiovascular Diseases, Rheumatic Diseases, Neurodegenerative Diseases
Register for Updates
Blood Collection for Development and Validation of Point-of-Care Diagnostic Liver Function Tests
NCT05457543
Recruiting
This is an observational study exploring the performance of a novel point-of-care diagnostic testing platform designed to quantitate the presence of liver function biomarkers such as bilirubin. Blood samples will be collected from participants to further development and validation of the testing platform to support FDA review. The diagnostic device is intended to provide rapid in-office test results using a finger stick of blood, a reaction test device, and a smartphone app.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/11/2022
Locations: Group K Diagnostics, Philadelphia, Pennsylvania
Conditions: Liver Diseases, Healthy, Liver Cirrhosis, Liver Fibrosis
Register for Updates