There are currently 17 active clinical trials seeking participants for Liver Diseases research studies. The states with the highest number of trials for Liver Diseases participants are California, Florida, Texas and New York.
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial
Recruiting
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) trial is a single center prospective adaptive phase 1b clinical trial in patients who are hospitalized with complications of liver disease and have low fecal metabolite levels (butyrate and deoxycholic acid). The study intervention is 1 of 9 novel live Commensal Consortia each containing eight commensal bacterial strains derived from healthy donors. The primary objective of the study is to determine safety and tolerability of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: The University of Chicago Medical Center, Chicago, Illinois
Conditions: Liver Diseases, Liver Failure, Cirrhosis, Liver
A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose
Recruiting
This is a research study to understand how liver impairment affects the way the body processes a new cancer medicine called sevabertinib (BAY 2927088). Sevabertinib is an experimental drug being developed to treat certain types of cancers that have specific genetic changes called HER2 mutations. This includes lung cancer, tumors that have spread to other parts of the body (metastatic), and tumors that cannot be removed with surgery (unresectable). Before this medicine can be given to cancer pat... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
08/01/2025
Locations: Clinical Pharmacology of Miami, LLC - Oncology Department, Miami, Florida +1 locations
Conditions: Hepatic Insufficiency, Liver Diseases, Pharmacokinetics, Drug Metabolism
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Recruiting
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectrum, bariatric surgery has shown promise in the treatment of MASLD/metabolic dysfunction-associated steatohepatitis (MASH) due to its efficacy in inducing weight loss. Nevertheless, its adoption has been... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obesity, Liver Diseases, Liver Fibrosis, Liver Fat, Weight Loss, Insulin Resistance, Insulin Sensitivity, Insulin Sensitivity/Resistance, Diabetes, Diabetes Mellitus, Type 2, NASH With Fibrosis, Non-Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver, Non-alcoholic Steatohepatitis, Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, MASLD, MASH, Metabolic Disease
Primary Sclerosing Cholangitis in Children
Recruiting
Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver's bile ducts. Bile ducts are tiny tubes that carry bile from the liver to the small intestine. Bile is a liquid produced by the liver that helps us absorb and use the nutrients in the food we eat. In people with PSC, the bile backs up into the liver and will damage it, causing scarring of the liver. The purposes of this study are to: * Collect medical and other data to learn more about PSC, how it progresses, a... Read More
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
05/19/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California +11 locations
Conditions: Primary Sclerosing Cholangitis, Liver Diseases, Cholangitis, Sclerosing
Genetic Collection Protocol
Recruiting
This study involves the one-time collection of whole blood or saliva samples for the extraction and storage of DNA for use in ongoing and future ChiLDReN studies.
Gender:
ALL
Ages:
Between 24 hours and 25 years
Trial Updated:
05/19/2025
Locations: Children's Hospital of Los Angeles, Los Angeles, California +12 locations
Conditions: Liver Diseases
Liver Cancer Prevention Randomized Control Trial
Recruiting
To determine the effectiveness of a behaviorally-based tailored disease management intervention in patients with fibrosis or steatosis and risk factors for cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Liver Diseases, Fibrosis, Liver, Cirrhosis, Liver
An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection
Recruiting
The TARGET-HBV study engages an observational research design to conduct a comprehensive review of outcomes for patients with CHB infection. The initial phase of the study that enrolled patients treated with tenofovir alafenamide (TAF) was successfully completed. The current protocol (Amendment 1) describes the second phase of the study that will engage research activities for patients being managed for CHB in usual clinical practice in the US and Canada. The study addresses important clinical q... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2025
Locations: Banner University Medical Center Phoenix, Phoenix, Arizona +30 locations
Conditions: Hepatitis B, Hepatitis, Liver Diseases
DILIN - Prospective Study
Recruiting
The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine. Recently added acute cases enrollment that meets criteria to the protocol. Also added Fibroscans to the protocol that will be completed at baseline and follow-up on chronic subjects.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
04/16/2025
Locations: University of Southern California, Los Angeles, California +5 locations
Conditions: Liver Diseases
Social & Contextual Impact on Children Undergoing Liver Transplantation
Recruiting
The social determinants of health have a large impact on health. For example, neighborhood socioeconomic deprivation is associated with increased risk of medication non-adherence, graft failure, and death in children after liver transplant. In order to address these socioeconomic inequities in outcomes, a more granular understanding of how the social determinants of health impact outcomes is needed. In this observational prospective cohort, caregivers of children undergoing liver transplantation... Read More
Gender:
ALL
Ages:
70 years and below
Trial Updated:
03/13/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +7 locations
Conditions: Liver Transplantation, Liver Diseases
Observational Pharmaco-Epidemiology Research & Analysis
Recruiting
Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provider-patient encounter that support realworld medical research and healthcare quality measure assessment. Real-world evaluations of treatments of chronic diseases in the context of comorbid conditions and... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
02/24/2025
Locations: Epividian, Durham, North Carolina
Conditions: Chronic Disease, HIV/AIDS, Liver Diseases, Inflammatory Bowel Diseases, Cardiovascular Diseases, Rheumatic Diseases, Neurodegenerative Diseases
Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
Recruiting
This is an open-label, non-randomized trial that will be conducted at three clinical sites, Thomas Jefferson University (TJU), the Hospital of the University of Pennsylvania (HUP) and University of Bern (UB). Enrollment will be allocated into one of 4 different cohorts depending on the inclusion criteria for each cohort. Cohort 1: Patients scheduled for hepatic vein pressure gradient (HVPG) measurements will subsequently undergo two consecutive SHAPE (subharmonic aided pressure estimation) pro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +2 locations
Conditions: Liver Diseases, Portal Hypertension
MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease
Recruiting
The purpose of the study is to study the muscle assessment score (MAsS, utilizing MRI, as an objective measure of frailty and muscle composition to serve as a predictor of morbidity and mortality in patients with liver disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: The University of Chicago, Chicago, Illinois
Conditions: Liver Diseases