There are currently 21 active clinical trials seeking participants for Liver Diseases research studies. The states with the highest number of trials for Liver Diseases participants are California, Florida, Texas and New York.
A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver Problems
Recruiting
This study is open to adults between 18 and 80 years of age. People with a body mass index (BMI) between 18 and 42 kg/m\^2 can take part. Women can only participate if they cannot get pregnant. This study includes people with mild liver problems, people with moderate liver problems, and people without liver problems as a matching control. The purpose of this study is to find out how mild and moderate liver problems affect how the body handles a medicine called zongertinib. Participants take zon... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/17/2025
Locations: American Research Corporation at the Texas Liver Institute, San Antonio, Texas
Conditions: Liver Diseases, Healthy
Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
Recruiting
This is an open-label, non-randomized trial that will be conducted at three clinical sites, Thomas Jefferson University (TJU), the Hospital of the University of Pennsylvania (HUP) and University of Bern (UB). Enrollment will be allocated into one of 4 different cohorts depending on the inclusion criteria for each cohort. Cohort 1: Patients scheduled for hepatic vein pressure gradient (HVPG) measurements will subsequently undergo two consecutive SHAPE (subharmonic aided pressure estimation) pro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +2 locations
Conditions: Liver Diseases, Portal Hypertension
An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection
Recruiting
The TARGET-HBV study engages an observational research design to conduct a comprehensive review of outcomes for patients with CHB infection. The initial phase of the study that enrolled patients treated with tenofovir alafenamide (TAF) was successfully completed. The current protocol (Amendment 1) describes the second phase of the study that will engage research activities for patients being managed for CHB in usual clinical practice in the US and Canada. The study addresses important clinical q... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2025
Locations: Banner University Medical Center Phoenix, Phoenix, Arizona +30 locations
Conditions: Hepatitis B, Hepatitis, Liver Diseases
RESTORE Declined Livers Study
Recruiting
This is a prospective, non-randomized, clinical trial of discarded liver transplants that have received normothermic machine perfusion (NMP), compared with standard cold preservation liver transplants. The discarded livers rejected by all other centers and meeting pre-NMP eligibility criteria will receive NMP using the OrganOx® metra device. The NMP-treated liver that meets the viability criteria will be transplanted to patients who are eligible and consented to the study. Liver transplant outco... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Liver Diseases, Surgery, Transplant; Failure, Liver
Implementation of a Digital Clinic for Alcohol-associated Liver Disease and Alcohol Use Disorder (DALC)
Recruiting
The purpose of this study is to determine whether a multidisciplinary digital clinic will improve health outcomes, reduce costs, increase access, and improve provider satisfaction. The primary aim of this study is to improve clinical outcomes in patients with ALD through the implementation of a novel digital health platform for personalized multi-disciplinary treatment of patients with ALD and AUD. Secondary aims include improvement in provider and patient-reported outcomes including satisfacti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/13/2024
Locations: Mayo Clinic Arizona, Scottsdale, Arizona +1 locations
Conditions: Alcohol Use Disorder, Liver Diseases
MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease
Recruiting
The purpose of the study is to study the muscle assessment score (MAsS, utilizing MRI, as an objective measure of frailty and muscle composition to serve as a predictor of morbidity and mortality in patients with liver disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: The University of Chicago, Chicago, Illinois
Conditions: Liver Diseases
Liver Cancer Prevention Randomized Control Trial
Recruiting
To determine the effectiveness of a behaviorally-based tailored disease management intervention in patients with fibrosis or steatosis and risk factors for cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/28/2024
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Liver Diseases, Fibrosis, Liver, Cirrhosis, Liver
Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)
Recruiting
Advanced liver disease is a serious illness that disproportionately affects Veterans, many of whom hope for curative liver transplantation. However, too few receive a transplant and most continue to suffer from increasing symptoms and hospitalizations. The proposed project uses a whole person, Veteran-centered approach that identifies Veterans with advanced liver disease using a population-based health management system and integrates curative and early supportive care using a telemedicine-based... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/03/2024
Locations: Central Arkansas Veterans Healthcare System , Little Rock, AR, Little Rock, Arkansas +3 locations
Conditions: Liver Diseases
A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease
Recruiting
Patients with complications of advanced liver disease often have difficulties after hospital discharge that result in early hospital readmission. Poor outcomes for these patients during this transitional time could be improved through the use of innovative transitional care models. This proposal aims to examine the effect of a transitional care model, The Transitional Liver Clinic (TLC), in reducing hospital re-admissions, improving quality of life, and improving patient experience.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2024
Locations: University of Chicago, Chicago, Illinois +3 locations
Conditions: Liver Diseases
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: Cedars-Sinai Comprehensive Transplant Center, Los Angeles, California +105 locations
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
Genetic Collection Protocol
Recruiting
This study involves the one-time collection of whole blood or saliva samples for the extraction and storage of DNA for use in ongoing and future ChiLDReN studies.
Gender:
ALL
Ages:
Between 24 hours and 25 years
Trial Updated:
07/30/2024
Locations: Children's Hospital of Los Angeles, Los Angeles, California +12 locations
Conditions: Liver Diseases
Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase
Recruiting
The "Genomic medicine Risk Assessment Care for Everyone" (GRACE)" intervention project will develop a scalable end-to-end solution for risk assessment and management that meets the needs of those populations living in low resource settings. The long-term goal is to increase access to and uptake of risk-informed evidence-based guidelines that will improve population health through better patient outcomes, higher quality of life, and decreased costs. The three primary aims are: Aim 1: Develop a s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2024
Locations: UF Health Callahan, Callahan, Florida +4 locations
Conditions: Cardiovascular Diseases, Cancer, Liver Diseases, Hyperthermia