There are currently 130 active clinical trials seeking participants for Major Depressive Disorder research studies. The states with the highest number of trials for Major Depressive Disorder participants are California, Florida, Texas and New York.
MicroRNA Correlates of Childhood Maltreatment and Suicidality
NCT04923685
Recruiting
This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA \[MiRNA\]) levels. miRNAs are a type of RNA (genetic material that is translated into protein) that are found in throughout the body and blood. They are called microRNA because their size is much smaller than typical RNA molecules. miRNAs are highly responsive to environment. This re... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/14/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +1 locations
Conditions: Major Depressive Disorder, Suicidal Ideation
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Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
NCT06058013
Recruiting
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD). The study design consists of a Screening Period (up to 28 days), and a 6-week Treatment Period (during which participants will receive either NMRA-335140 or placebo). At the completion of the 6-week Treatment Period, participants who complete the study, provide informed consent, and... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/10/2025
Locations: Neumora Investigator Site, Encino, California +59 locations
Conditions: Major Depressive Disorder
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Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
NCT06695767
Recruiting
The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, Texas +1 locations
Conditions: Major Depressive Disorder, Epilepsy
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Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
NCT05892744
Recruiting
The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective serotonin reuptake inhibitor (SSRI) antidepressant. Our central hypothesis is that brain activity and connections jointly measured with functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) will be able to predict an individual's response to sertraline tr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/07/2025
Locations: Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas
Conditions: Major Depressive Disorder, Chronic Major Depression, Recurrent
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A Trial of the Safety and Efficacy of SEP-363856 in the Treatment of Adults With Major Depressive Disorder
NCT05593029
Recruiting
This is a Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial of the Safety and Efficacy of Flexible Doses of SEP-363856 as Adjunctive Therapy in the Treatment of Adults with Major Depressive Disorder (MDD)
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/24/2024
Locations: For additional information regarding sites, contact 844-687-8522, New York, New York
Conditions: Major Depressive Disorder
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The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
NCT05786066
Recruiting
The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
12/19/2024
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Depressive Disorder, Major Depressive Disorder, Bipolar Disorder, Post Traumatic Stress Disorder, Suicidal Ideation
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Pain and Major Depressive Disorder
NCT04556890
Recruiting
This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 treatments of blinded transcranial magnetic stimulation. There is no control group as all subjects will receive some form of active treatment. Subjects are required to participate in 30-33 study visits... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/17/2024
Locations: UCLA Semel Institute, Los Angeles, California
Conditions: Major Depressive Disorder, Chronic Pain
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Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
NCT04620759
Recruiting
The purpose of this study is to determine whether psilocybin, a hallucinogenic drug, is effective in reducing depressive symptoms and amount of drinking in patients with co-occurring Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD).
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
12/16/2024
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Major Depressive Disorder, Alcohol Use Disorder
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Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression
NCT06730841
Recruiting
This study aims to evaluate the feasibility, safety, and tolerability of an innovative approach to treating Major Depressive Disorder (MDD), particularly in cases where patients have not responded well to traditional therapies. Specifically, the objective is to evaluate the antidepressant effects of a Dose-Optimized and Spaced Transcranial Direct Current Stimulation (DOS-tDCS) protocol in participants with treatment-resistant depression (TRD) compared to spaced tDCS only and sham tDCS in a 3-arm... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/11/2024
Locations: UCSD Interventional Psychiatry, San Diego, California
Conditions: Treatment Resistant Depression, Major Depressive Disorder
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Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
NCT06523439
Recruiting
This is a single-site open-label clinical trial of the Stanford Accelerated Intermittent Neuromodulation Therapy (SAINT®) protocol. The goal of this clinical trial is to learn if a new form of transcranial magnetic stimulation (TMS)-known generally as accelerated intermittent theta burst stimulation (aiTBS) and specifically as SAINT®-is effective as a first-line therapy in treating adolescents aged 14-19 years-old in their first episode of depression who have not undergone a full course of depre... Read More
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
12/06/2024
Locations: Dell Medical School at University of Texas at Austin, Austin, Texas
Conditions: Major Depressive Disorder, Depression in Adolescence, Depression, Major Depressive Episode
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Antidepressant Effects of Nitrous Oxide
NCT05357040
Recruiting
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people with major depressive disorder; and further evaluate these effects by identifying the optimal dose and regimen to guide current practice, and to plan a future large pragmatic trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Chicago Medicine, Chicago, Illinois +1 locations
Conditions: Major Depressive Disorder, Treatment Resistant Depression
Register for Updates
Technology-Assisted Implementation of a Mobile Health Program for Serious Mental Illness
NCT05725785
Recruiting
The goal of this clinical trial is to learn about how a digital training platform can enhance implementation and effectiveness of a validated mHealth system, called FOCUS, in people with serious mental illness. The main question this research aims to answer is whether patients obtain similar outcomes to previous FOCUS studies when using FOCUS with clinicians trained on a newly developed digital training platform. Participants will be asked to use the FOCUS smartphone application and receive mob... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Places for People, St. Louis, Missouri +2 locations
Conditions: Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Schizo Affective Disorder
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