Search
Opioid Use Clinical Trials
A listing of 66 Opioid Use clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 66
There are currently 66 active clinical trials seeking participants for Opioid Use research studies. The states with the highest number of trials for Opioid Use participants are California, Pennsylvania, New York and North Carolina.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Offer
Lose Weight with GLP-1 Medications
Recruiting
Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to semaglutide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
Recruiting
This hybrid implementation-effectiveness trial will evaluate Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment (MT). The investigators will also assess barriers and facilitators to integrating MORE into methadone treatment, and evaluate the impact of a sustainable train-the-trainer model on provider burden, intervention fidelity, intervention engagement, and outcomes. Participants will be assigned to a higher intensity MORE imple... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey +1 locations
Conditions: Opioid Use, Pain
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
Recruiting
The goal of this randomized controlled trial is to examine if there is a relationship between the addition of the genicular nerve block and anterior femoral cutaneous nerve block in providing analgesia and the use of oral and intravenous medication in patients undergoing a total knee arthroplasty. The main questions it aims to answer are:
1. Does incorporating genicular nerve block and anterior femoral cutaneous nerve block to our current standard of care reduce patients' total opioid consumpti... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/22/2025
Locations: Hospital for Special Surgery, New York, New York
Conditions: Total Knee Replacement, Genicular Nerve Block, Opioid Use
Sleep Disordered Breathing With Opioid Use
Recruiting
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical para... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/16/2025
Locations: John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan
Conditions: Sleep Apnea, Opioid Use, Sleep Disordered Breathing
QL vs LAI for Palatoplasty
Recruiting
This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting). The patients will be randomized to receive either a unilateral QL block by an anesthesiologist, or local anesthetic infiltration at the surgical incision by the surgeon. The primary aim will be assessing post-operative pain in the first 48 hours after surgery. Secondary outcomes wi... Read More
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
07/01/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Post-operative Pain, Opioid Use, Cleft Palate
Enhancing Prospective Thinking in Early Recovery (PARK)
Recruiting
The goal of this clinical trial is to demonstrate the commercial potential for a novel virtual reality (VR) intervention in preparation for Phase II development. This clinical trial will test the VR intervention for efficacy in reducing opioid use, increasing abstinence, and other self-reported and behavioral focus on future outcomes in individuals in early recovery from opioid use disorder.
* Will the VR group, compared to the control group, have a lower number of opioid use days?
* Will the V... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/27/2025
Locations: Indiana University School of Medicine - Goodman Hall, Indianapolis, Indiana +2 locations
Conditions: Opioid Use, Opioid Use Disorder, Substance Use Disorders
rTMS as Add on Treatment for Substance Use Disorders
Recruiting
This pilot study is designed to test feasibility and superiority of rTMS types and target locations for the optimal rTMS intervention for individuals seeking treatment for Alcohol Use Disorder (AUD) or Opioid Use Disorder (OUD).
The critical questions this study seeks to answer are: which rTMS type applied to l-dlPFC in OUD participants will induce the greatest reduction of opioid use post-treatment? Is inhibitory rTMS applied to medial prefrontal cortex (mPFC) more effective than excitatory rT... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/27/2025
Locations: Hartford Healthcare, Hartford, Connecticut
Conditions: Opioid Use, Alcohol Use Disorder
Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
Recruiting
The goal of this clinical trial is to learn about how certain medications used to treat insomnia (e.g., Lemborexant) impact sleep, mood, and behavior in men and women with Opioid Use Disorder who are taking prescribed buprenorphine. The main questions it aims to answer are:
1. What is the effect of the study drug (lemborexant) on sleep outcomes?
2. What is the effect of the study drug (lemborexant) on impulsive behavior (as measured by computer test performance)?
3. What is the effect of the st... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: VCU Institute for Drug and Alcohol Studies, Richmond, Virginia
Conditions: Opioid Use Disorder, Opioid Use, Insomnia, Orexin Antagonist
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
Recruiting
The goal of this project is to test the effects of the VibraCool mechanical stimulation neuromodulatory therapeutic device on post-operative pain and opioid use following anterior crucitate ligament reconstruction (ACLR), and thus residual opioids in circulation.
Gender:
ALL
Ages:
All
Trial Updated:
06/25/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: ACL, Opioid Use, Cryotherapy Effect, Vibration; Exposure, Pain, Postoperative
Culturally Responsive Community Driven Substance Use Recovery for Black and Latinx Population
Recruiting
The main goal of this current study is to develop and optimize methods for increasing access to, uptake of, and engagement in MAT (Medication Assisted Treatment) among communities of color.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/20/2025
Locations: Mount Aery Baptist Church, Bridgeport, Connecticut +7 locations
Conditions: Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
Recruiting
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism (low testosterone).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use, Pain, Hypogonadism, Male
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Recruiting
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Rogers Behavioral Health, Oconomowoc, Wisconsin +1 locations
Conditions: Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Opioid Dispensing Device for Post-Operative Pain in Cancer Patients
Recruiting
This research study will evaluate the use of, and participants experience with, a new device called Addinex that safely stores and dispenses opioid medication. The purpose of this study is to evaluate the use of the Addinex device in cancer patients undergoing cancer-related surgery that require pain control with opioids after the surgery. Participants will be asked to answer questions about their medical history and background, fill out questionnaires, use a mobile application associated with t... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/27/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: Opioid Use, Breast Cancer
1 - 12 of 66