There are currently 15 active clinical trials seeking participants for Sarcopenia research studies. The states with the highest number of trials for Autism participants are Illinois, Florida, Texas and Massachusetts.
Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
NCT04869813
Recruiting
The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.
Gender:
All
Ages:
40 years and above
Trial Updated:
01/23/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Sarcopenia
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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
NCT03998202
Recruiting
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.
Gender:
All
Ages:
60 years and above
Trial Updated:
04/04/2024
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +161 locations
Conditions: Colorectal Cancer, Sarcopenia
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Effects of Multicomponent Training on Sarcopenia
NCT06094413
Recruiting
The purpose of the study is to determine whether community-dwelling older adults with probable sarcopenia (muscle loss) will experience improved patient-reported outcomes and physical performance after completing an 8-week multicomponent exercise training program when compared to a control group who does not complete the intervention. As an additional aim, subjects who participate in the exercise intervention will be asked about their experiences to identify factors that contribute to positive h... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
03/25/2024
Locations: Geisinger 65Forward, Scranton, Pennsylvania
Conditions: Sarcopenia
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Ankle Assistance and Resistance in Older Adults
NCT06284525
Recruiting
The goal of this research protocol is to improve mobility in older individuals through advances in wearable assistive devices by focusing on two specific aims. The first aim is to study if targeted ankle resistance gait training improves walking performance in older individuals. The second aim is to evaluate the potential of wearable assistance at the ankle, knee, and/or hip joints to increase walking performance in older individuals.
Gender:
All
Ages:
Between 65 years and 85 years
Trial Updated:
02/21/2024
Locations: Northern Arizona University, Flagstaff, Arizona
Conditions: Sarcopenia
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Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet
NCT05658263
Recruiting
The long-term study objective is to develop optimized nutritional therapies for surgery and test them in clinical practice. This pilot study will test a microbiome-optimization diet in colorectal cancer surgery patients. The study hypothesizes that the Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet will provide participants with increased microbiota accessible carbohydrates (MACs) to support the microbiome and improve outcomes.
Gender:
All
Ages:
Between 25 years and 70 years
Trial Updated:
01/11/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Dysbiosis, Sarcopenia, Colon Cancer
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The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults
NCT06157385
Recruiting
Aging is associated with a decline in muscle mass, strength, and physical function, leading to sarcopenia and frailty. This deterioration of muscle and physical capabilities impacts an individual's functional independence and quality of life. Dietary protein stimulates muscle protein synthesis. Therefore, nutritional interventions that recommend higher protein intakes may enhance muscle protein synthesis. Food intake, including protein-rich foods such as red meat, has been shown to decline with... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
11/27/2023
Locations: Texas Tech University, Lubbock, Texas
Conditions: Sarcopenia
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Body Composition Changes After TIPS and Associated Clinical Outcomes
NCT05420753
Recruiting
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients awaiting liver transplantation. Retrospective observational studies have shown improvement in muscle mass and body composition in cirrhotic patients undergoing TIPS. The investigators aim to now prospectively study this through a pilot randomized controlled trial tracki... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
11/02/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Cirrhosis, Liver, Sarcopenia
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Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
NCT04691986
Recruiting
Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been linked to physical performance decline in animals. Human trials have demonstrated that nicotinamide riboside (NR), a form of vitamin B3, is safe and effectively increases NAD+ levels. In animal studies... Read More
Gender:
All
Ages:
Between 65 years and 85 years
Trial Updated:
10/24/2023
Locations: Kansas City VA Medical Center, Kansas City, MO, Kansas City, Missouri
Conditions: Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content
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Adverse Outcomes and Mortality in Liver Transplant
NCT05477277
Recruiting
Prospective natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Mayo Clinic Arizona, Phoenix, Arizona
Conditions: End Stage Liver DIsease, Sarcopenia, Sarcopenic Obesity, Cirrhosis
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C-Protein in Fatigue and Aging
NCT05926219
Recruiting
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/06/2023
Locations: University of Oregon, Eugene, Oregon
Conditions: Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly, Sarcopenia
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The Influence of Daily Grapes Intake on Sarcopenia in Postmenopausal Women
NCT05863507
Recruiting
Sarcopenia, characterized by loss of muscle mass and function, is a prevalent disorder in elderly individuals or individuals with chronic diseases. Given the above, there is an ongoing intensive search for novel therapies, including dietary ones, that can attenuate the loss of muscle mass and strength in the elderly. A proposed mechanism by which skeletal muscles might mediate their protective effect against sarcopenia is by secreting myokines as irisin. Phenolic compounds presents in grape have... Read More
Gender:
Female
Ages:
60 years and above
Trial Updated:
09/28/2023
Locations: Nutrition Department, Ragle Facility University of California, Davis, Davis, California
Conditions: Sarcopenia
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Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
NCT04717869
Recruiting
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California
Conditions: Frailty, Sarcopenia
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