There are currently 91 active clinical trials seeking participants for Sickle Cell Disease research studies. The states with the highest number of trials for Sickle Cell Disease participants are New York, North Carolina, California and Georgia.
Effects of the Contraceptive Implant in Women With Sickle Cell Disease
NCT05730205
Recruiting
The objective of this study is to measure the acceptability and impact of the progestin implant on frequency of vaso-occlusive crises, quality of life, and hematologic parameters in women with SCD.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/31/2025
Locations: Penn Medicine University City, Philadelphia, Pennsylvania
Conditions: Sickle Cell Disease
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A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease
NCT04484272
Recruiting
Our long-term goal is to reduce stress and improve sickle cell disease (SCD) pain control with less opioid use through an intervention with self-management relaxation/distraction exercises (RDE), named You Cope, We Support (YCWS). Americans living with SCD suffer recurrent episodes of acute and chronic pain, both of which are exacerbated by stress. Building on the successes of our prior formative studies, we now propose a well-designed, appropriately powered study to test efficacy of YCWS on out... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/31/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Sickle Cell Disease
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Sickle Cell, Pain and Mediterranean Diet
NCT06886477
Recruiting
The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Sickle Cell, Sickle Cell Disease, Sickle Cell Disease Without Crisis, Mediterranean Diet
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Trans-auricular Vagal Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
NCT07090668
Recruiting
The goal of this study is to evaluate the effects of transauricular vagal nerve stimulation on the treatment of pain in children with Sickle Cell Disease. * The primary objective is to determine the feasibility of using a taVNS device to treat pain in pediatric participants with SCD by assessing the completion rate, stimulation tolerability, and acceptability of the intervention measures. * The secondary objective is to assess the preliminary efficacy of using a taVNS device as a remedy for pai... Read More
Gender:
ALL
Ages:
Between 7 years and 18 years
Trial Updated:
07/21/2025
Locations: Children's Hospital of Atlanta: Eagelston, Atlanta, Georgia
Conditions: Sickle Cell Disease
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Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
NCT07083531
Recruiting
This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
07/16/2025
Locations: UConn Health, Farmington, Connecticut
Conditions: Sickle Cell Disease, Sickle Cell Trait
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Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
NCT05583721
Recruiting
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET st... Read More
Gender:
ALL
Ages:
Between 18 years and 21 years
Trial Updated:
07/14/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Sickle Cell Disease
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A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
NCT06612268
Recruiting
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can reduce the damage to different organs, improve your exercise tolerance and reduce fatigue in people with sickle cell disease.The participants will either get etavopivat or placebo. Which treatment the par... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/14/2025
Locations: Uni of Alabama at Birmingham, Birmingham, Alabama +160 locations
Conditions: Sickle Cell Disease
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Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
NCT05170412
Recruiting
Background: Sickle Cell Disease (SCD) causes blood cells form a crescent shape. It is caused by a genetic mutation in the hemoglobin gene. People with SCD are at increased risk for illnesses like stroke, chronic pain, and heart problems, as well as decreased overall health and well-being. Researchers want to learn more about how nutrition and diet can help relieve or reduce the symptoms of SCD. Objective: To understand how diet, dietary patterns and behaviors, nutrition, and other related fac... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
07/09/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Sickle Cell Disease
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Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
NCT02447874
Recruiting
The purpose of this study is to determine whether giving extra arginine to patients with sickle cell disease seeking treatment for vaso-occlusive painful events (VOE) will decrease pain scores, decrease need for pain medications or decrease length of hospital stay or emergency department visit.
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
07/08/2025
Locations: Children's Healthcare fo Atlanta at Hughes Spalding, Atlanta, Georgia +1 locations
Conditions: Sickle Cell Disease
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Exercise in Child Health
NCT05359991
Recruiting
This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate Lurie Children's Hospital), and 3) USC (with its affiliate Children's Hospital of Los Angeles). There is an increasing number of children who, through medical advances, now survive diseases and conditions that were once fatal, but which remain chronic a... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
07/07/2025
Locations: University of California, Irvine, Irvine, California
Conditions: Cystic Fibrosis, Sickle Cell Disease, SARS CoV 2 Infection
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The Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-cell Disease
NCT06975865
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential study (Part A), followed by an open-label LTE period (Part B) to investigate the efficacy, and safety of rilzabrutinib in participants with sickle-cell disease (SCD). Study details include: * Study duration: a 52-week double-blind period (Part A), followed by an open-label LTE period (Part B). Double-blind period has two parts, 50% (adult only) until the interim analysis (a proof-concept part... Read More
Gender:
ALL
Ages:
Between 10 years and 65 years
Trial Updated:
07/04/2025
Locations: Bioresearch Partners- Site Number : 8400005, Hialeah, Florida +2 locations
Conditions: Sickle Cell Disease
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Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
NCT06944067
Recruiting
The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfusions. This response is called an alloimmune response. We strongly believe that when someone has an alloimmune response, it is caused by changes in their genes. We plan to compare changes in the genes of individuals that develop red blood cell alloimmunization after blood transfusions with those that... Read More
Gender:
ALL
Ages:
Between 2 years and 99 years
Trial Updated:
06/26/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Sickle Cell Disease
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