There are currently 95 active clinical trials seeking participants for Sickle Cell Disease research studies. The states with the highest number of trials for Sickle Cell Disease participants are New York, North Carolina, California and Georgia.
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
Recruiting
The goal of this research study is to reduce stress and improve sickle cell disease (SCD) pain control and sleep quality with less opioid use by determining the feasibility of an intervention with self-management combined intercessory and petitionary prayer, named Pray Until Something Happens (PUSH) stress reduction intervention using a mobile smart device. Currently, opioid analgesics are primarily used to treat SCD pain while self-managed behavioral modalities such as PUSH, are rarely used. Li... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/24/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Sickle Cell Disease, Stress, Pain
Integrative Training Program for Pediatric Sickle Cell Pain
Recruiting
This research aims to answer the question: does a group training program specifically for teens with chronic sickle cell disease (SCD) pain that teaches skills to strengthen the mind and body help improve everyday functioning and reduce pain symptoms? The program will be tailored to address challenges related to frequent or chronic sickle cell pain and may improve participants' physical and emotional health. The program, called I-STRONG for SCD (Integrative Strong Body and Mind Training for Si... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
01/21/2025
Locations: Connecticut Children's Medical Center, Hartford, Connecticut +3 locations
Conditions: Sickle Cell Disease
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Recruiting
Background: Sickle Cell Disease (SCD) causes blood cells form a crescent shape. It is caused by a genetic mutation in the hemoglobin gene. People with SCD are at increased risk for illnesses like stroke, chronic pain, and heart problems, as well as decreased overall health and well-being. Researchers want to learn more about how nutrition and diet can help relieve or reduce the symptoms of SCD. Objective: To understand how diet, dietary patterns and behaviors, nutrition, and other related fac... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
01/18/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Sickle Cell Disease
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir
Recruiting
This is a study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of Pociredir in participants with sickle cell disease.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/17/2025
Locations: University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas +19 locations
Conditions: Sickle Cell Disease, Sickle Cell Anemia
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Recruiting
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET st... Read More
Gender:
ALL
Ages:
Between 18 years and 21 years
Trial Updated:
01/17/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Sickle Cell Disease
Cerebral Oxygen Metabolism in Children
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, su... Read More
Gender:
ALL
Ages:
Between 3 years and 50 years
Trial Updated:
01/14/2025
Locations: Washington University of St. Louis, Saint Louis, Missouri
Conditions: Sickle Cell Disease, Cerebral Stroke
Metabolic and Hemodynamic Reserve in Pediatric SCA
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those without, reflecting a greater loss. The investigators will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and cons... Read More
Gender:
ALL
Ages:
Between 4 years and 21 years
Trial Updated:
01/14/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Child, Only, Brain Diseases, Sickle Cell Disease, Anemia, Sickle Cell
Virtual Reality As Adjunct Therapy for Vaso-Occlusive Pain
Recruiting
The goal of this randomized control clinical trial is to learn if virtual reality can be used to treat sickle cell pain in children. The main questions it aims to answer are: Does virtual reality reduce pain severity during a child's hospital stay for a vaso-occlusive pain crisis? Does virtual reality decrease the daily use of opiates? Researchers will compare standard therapy to the use of standard therapy plus a daily virtual reality experience to see if virtual reality works to treat sickl... Read More
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
01/13/2025
Locations: Children's Hospital of New Orleans, New Orleans, Louisiana
Conditions: Sickle Cell Disease, Vaso-occlusive Pain Episodes
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
Recruiting
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/09/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +19 locations
Conditions: Sickle Cell Disease
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Recruiting
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD. EndeavorRx (Akili Interactive Labs: Boston, MA) is an FDA-approved home-based, electronic attentional-control training program designed to treat attention problems in youth. Users access EndeavorRx on a tablet device for 25-30 minutes each day, 5 days per week, for 4 weeks. The program involves training in a game-like environm... Read More
Gender:
ALL
Ages:
Between 8 years and 16 years
Trial Updated:
01/08/2025
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
Recruiting
Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individual patients. This study proposes to monitor SCD and its treatment through their impact on cerebral hemodynamics, as the brain is one of the most vulnerable and consequential targets of the disease. Sp... Read More
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
01/07/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sickle Cell Disease
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease
Recruiting
This is a study to evaluate the safety and toxicity of a treatment regimen consisting of 2 cycles of pre-transplant immunosuppressive therapy followed by myeloablative preparative regimen and allogeneic hematopoietic stem cell transplantation from a haploidentical donor in patients with sickle cell disease. The overall goal of this study is to expand the donor pool for hematopoietic stem cell transplantation in sickle cell disease using haploidentical donors, and to develop a non-toxic, myeloab... Read More
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
01/02/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Sickle Cell Disease