There are currently 93 active clinical trials seeking participants for Sickle Cell Disease research studies. The states with the highest number of trials for Sickle Cell Disease participants are New York, North Carolina, California and Georgia.
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
Recruiting
The goal of this research study is to reduce stress and improve sickle cell disease (SCD) pain control and sleep quality with less opioid use by determining the feasibility of an intervention with self-management combined intercessory and petitionary prayer, named Pray Until Something Happens (PUSH) stress reduction intervention using a mobile smart device. Currently, opioid analgesics are primarily used to treat SCD pain while self-managed behavioral modalities such as PUSH, are rarely used. Li... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/24/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Sickle Cell Disease, Stress, Pain
Integrative Training Program for Pediatric Sickle Cell Pain
Recruiting
This research aims to answer the question: does a group training program specifically for teens with chronic sickle cell disease (SCD) pain that teaches skills to strengthen the mind and body help improve everyday functioning and reduce pain symptoms? The program will be tailored to address challenges related to frequent or chronic sickle cell pain and may improve participants' physical and emotional health. The program, called I-STRONG for SCD (Integrative Strong Body and Mind Training for Si... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
01/21/2025
Locations: Connecticut Children's Medical Center, Hartford, Connecticut +3 locations
Conditions: Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Recruiting
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET st... Read More
Gender:
ALL
Ages:
Between 18 years and 21 years
Trial Updated:
01/17/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Sickle Cell Disease
Cerebral Oxygen Metabolism in Children
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, su... Read More
Gender:
ALL
Ages:
Between 3 years and 50 years
Trial Updated:
01/14/2025
Locations: Washington University of St. Louis, Saint Louis, Missouri
Conditions: Sickle Cell Disease, Cerebral Stroke
Metabolic and Hemodynamic Reserve in Pediatric SCA
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those without, reflecting a greater loss. The investigators will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and cons... Read More
Gender:
ALL
Ages:
Between 4 years and 21 years
Trial Updated:
01/14/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Child, Only, Brain Diseases, Sickle Cell Disease, Anemia, Sickle Cell
Virtual Reality As Adjunct Therapy for Vaso-Occlusive Pain
Recruiting
The goal of this randomized control clinical trial is to learn if virtual reality can be used to treat sickle cell pain in children. The main questions it aims to answer are: Does virtual reality reduce pain severity during a child's hospital stay for a vaso-occlusive pain crisis? Does virtual reality decrease the daily use of opiates? Researchers will compare standard therapy to the use of standard therapy plus a daily virtual reality experience to see if virtual reality works to treat sickl... Read More
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
01/13/2025
Locations: Children's Hospital of New Orleans, New Orleans, Louisiana
Conditions: Sickle Cell Disease, Vaso-occlusive Pain Episodes
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
Recruiting
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/09/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +19 locations
Conditions: Sickle Cell Disease
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Recruiting
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD. EndeavorRx (Akili Interactive Labs: Boston, MA) is an FDA-approved home-based, electronic attentional-control training program designed to treat attention problems in youth. Users access EndeavorRx on a tablet device for 25-30 minutes each day, 5 days per week, for 4 weeks. The program involves training in a game-like environm... Read More
Gender:
ALL
Ages:
Between 8 years and 16 years
Trial Updated:
01/08/2025
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
Recruiting
Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individual patients. This study proposes to monitor SCD and its treatment through their impact on cerebral hemodynamics, as the brain is one of the most vulnerable and consequential targets of the disease. Sp... Read More
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
01/07/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sickle Cell Disease
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease
Recruiting
This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. Conditioning regimens are treatments used to prepare a patient for stem cell transplantation. A stem cell transplant is a procedure in which a person receives blood stem cells, which make any type of blood cell. A conditioning regimen may include chemotherapy, monoclonal antibody therapy, and radiation to the entire... Read More
Gender:
ALL
Ages:
Between 12 years and 40 years
Trial Updated:
12/30/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Sickle Cell Disease
Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
Recruiting
This multisite prospective study seeks to determine if HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus (Sickle transplant Using a Nonmyeloablative approach, "SUN") can decrease the toxicity of transplant while achieving a high cure rate for children with sickle cell disease (SCD).
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
12/19/2024
Locations: Children's National Health System, Washington, District of Columbia +6 locations
Conditions: Sickle Cell Disease
Exercise in Child Health
Recruiting
This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate Lurie Children's Hospital), and 3) USC (with its affiliate Children's Hospital of Los Angeles). There is an increasing number of children who, through medical advances, now survive diseases and conditions that were once fatal, but which remain chronic a... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
12/12/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Cystic Fibrosis, Sickle Cell Disease, SARS CoV 2 Infection