There are currently 123 active clinical trials seeking participants for Spinal Cord Injuries research studies. The states with the highest number of trials for Spinal Cord Injuries participants are Texas, New York, Florida and Illinois.
Role of Endothelial Function in SCI CVD Risk
Recruiting
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in t... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
08/19/2024
Locations: Craig Hospital, Englewood, Colorado
Conditions: Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction
Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder
Recruiting
The purpose of this study is to determine if electric stimulation to the leg, called transcutaneous tibial nerve stimulation (TTNS), can improve bladder outcomes in acute spinal cord injury.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/15/2024
Locations: MedStar National Rehabilitation Hospital, Washington, District of Columbia +1 locations
Conditions: Spinal Cord Injuries
Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury
Recruiting
The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with chronic spinal cord injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +2 locations
Conditions: Spinal Cord Injuries, Neuropathic Pain
Effects of 5HTP on the Injured Human Spinal Cord
Recruiting
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/06/2024
Locations: University of Louisville, Louisville, Kentucky +1 locations
Conditions: Spinal Cord Injuries
Pharmacological Agents for Chronic Spinal Cord Injury (SCI)
Recruiting
The purpose of this study is to investigate the short-term effects of 3 approved FDA drugs (cyproheptadine (CPH), carbidopa-levodopa (CD-LD), and atomoxetine (ATX)) on motor responses when delivered in combination with hand training exercises in people with chronic spinal cord injury. The goal is to learn how to better strengthen connections between the brain and spinal cord after spinal cord injury, and if this connection is improved by one(or more) of the drugs. Multiple aspects of nerve trans... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/05/2024
Locations: James J. Peters Veterans Affairs Medical Center, Bronx, New York
Conditions: Spinal Cord Injuries
Usability of the Adapted Rower for People With Spinal Cord Injury
Recruiting
The goal of this clinical trial is to examine usability of a locally built adaptive rower for people with spinal cord injury using an established and tested design. The main questions it aims to answer are: 1. What exercise intensity of activity do users achieve on the rower for steady state and interval rowing plans? 2. What assistance is required for setup and usage of the adaptive rower? 3. What do users think about the ease of use and what is their satisfaction with the adaptive rower? Pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: Public Health Research Center, Columbia, South Carolina
Conditions: Spinal Cord Injuries
Multi-speed Ergonomic Wheelchair
Recruiting
Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain. Severe shoulder pain can lead some wheelchair users to transition from manual to powered mobility, complicating transportation, and reducing independence in activities of daily living. This project will expand the understanding of a new wheelchair design that allows better positioning o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2024
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: Spinal Cord Diseases, Spinal Cord Injuries
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea
Recruiting
Mild intermittent hypoxia (IH) initiates sustained increases in chest wall and upper airway muscle activity in humans. This sustained increase is a form of respiratory plasticity known as long-term facilitation (LTF). Repeated daily exposure to mild IH that leads to the initiation of LTF of upper airway muscle activity could lead to increased stability of the upper airway. In line with PI's laboratory's mandate to develop innovative therapies to treat sleep apnea, this increased stability could... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/18/2024
Locations: John D Dingell VA Medical Center, Detroit, Michigan +1 locations
Conditions: Obstructive Sleep Apnea, Spinal Cord Injuries
Autologous Adipose Derived Mesenchymal Stem Cells for Spinal Cord Injury Patients
Recruiting
The purpose of this research study is to investigate the safety and potential therapeutic effects of autologous, culture-expanded, adipose derived mesenchymal stem cell intrathecal injections in the treatment of spinal cord injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Spinal Cord Injuries, Paralysis
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
Recruiting
People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical currents using skin electrodes over the lower back and belly. The investigators want to see how well the intervention of transcutaneous spinal stimulation performs by testing different levels of stimulatio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/28/2024
Locations: Methodist Rehabilitation Center, Jackson, Mississippi +1 locations
Conditions: Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
Recruiting
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles. The purpose of this project is to test the safety, comfort, and practicality of a new therapy that stimulates the spinal cord to facilitate activation of arm and hand muscles while practicing grasping, pinching, and reaching movements. The long-term goal is to provide better therapies that will improve the ability of children with SCI to m... Read More
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
06/20/2024
Locations: Department of Neurosurgery, Louisville, Kentucky
Conditions: Spinal Cord Injuries
Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study
Recruiting
This study seeks to conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/19/2024
Locations: Kessler Foundation, East Hanover, New Jersey
Conditions: Spinal Cord Injuries, Cognitive Dysfunction, Cognitive Impairment, Acute Spinal Cord Injury