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Substance Use Clinical Trials
A listing of 52 Substance Use clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 52
There are currently 52 active clinical trials seeking participants for Substance Use research studies. The states with the highest number of trials for Substance Use participants are California, New York, Texas and Florida.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Type 2 Diabetes Clinical Trial
Recruiting
Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.
Conditions:
Type 2 Diabetes
Diabetes Mellitus Type 2 in Obese
Diabetes Type Two
Type 2 Diabetes Mellitus
Diabete Type 2
Featured Trial
Crohn's Disease Clinical Study
Recruiting
Help us study a potential new way to treat Crohn's disease. We are seeking adults living with Crohn's disease to join our latest clinical trial to help us learn more. Eligible participants will receive study-related treatment, assessments, and care at no cost. You will also receive reimbursement for travel while participating. Health insurance is not required to take part.
Conditions:
Crohn's Disease
Crohn Disease
Crohns Disease
Crohn's Disease (CD)
Crohn Colitis
Featured Offer
Lose Weight with GLP-1 Medications
Recruiting
Policy Lab has partnered with CareGLP to offer trusted access to GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
The STop UNhealthy Substance Use Now Trial
Recruiting
The STop UNhealthy (STUN) Substance Use Now Trial (STUN II) is a multisite trial aiming to evaluate the comparative effectiveness of the following strategies for improving the implementation of screening and interventions for substance use disorders in primary care: practice facilitation (PF), PF plus a learning collaborative (LC), PF plus performance incentives (PI), and PF+LC+PI. We plan to enroll 144 clinic staff participants from 48 primary care practices
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2025
Locations: Bon Secours Mercy Health, Cincinnati, Ohio +2 locations
Conditions: Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Recruiting
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Rogers Behavioral Health, Oconomowoc, Wisconsin +1 locations
Conditions: Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Journey of Transformation Curriculum for Native American Youth
Recruiting
The investigators will conduct a waitlist control trial to test the efficacy of the Journey of Transformation-Native Youth Health Leadership Program (JOT) in terms of delaying or reducing tobacco and other substance use and improving sexual health.
Gender:
ALL
Ages:
Between 13 years and 16 years
Trial Updated:
05/20/2025
Locations: University of Washington, Seattle, Washington
Conditions: Alcohol Drinking, Tobacco Use, Substance Use, Sexual Behavior
Open-Label Psilocybin Study in Transdiagnostic Population
Recruiting
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to psychiatric symptoms will experience statistically significant symptom reduction and functional improvement from baseline symptom measurements (Visit 3) to 1-week (Visit 7), 4-weeks (Visit 8), and 6-w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut
Conditions: Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms, PTSD, Substance Use, Substance Use Disorder (SUD), OCD
The Collaborative Care PrTNER Study
Recruiting
A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk for HIV) and decrease viral load (for those living with HIV) among young Black and Latino men who have sex with men (YBLMSM) aged 15 to 24 through engagement in SU treatment.
Gender:
MALE
Ages:
Between 15 years and 24 years
Trial Updated:
05/19/2025
Locations: Johns Hopkins Center for Adolescent and Young Adult Health, Baltimore, Maryland +1 locations
Conditions: HIV, Substance Use Disorders, Substance Use, AIDS
Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)
Recruiting
The purpose of this trial is to test the efficacy of a collaborative care intervention to address opioid- and/or stimulant-involved polysubstance use in adult primary care patients with moderate to severe substance use disorders (SUD). The primary aims are to reduce days of opioid use (illicit or nonmedical opioid use), days of illicit stimulant use (cocaine, methamphetamine), and days of heavy alcohol use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2025
Locations: Harbor-UCLA Medical Center, Torrance, California +7 locations
Conditions: Substance Use
A Brief Intervention for Alcohol Users With Interpersonal Trauma
Recruiting
The current proposal aims to enhance a mobile-delivered brief intervention for young adults with heavy alcohol use and interpersonal trauma by including adaptive coping strategies for managing trauma-related distress and using peer coaches after delivery of the intervention to maintain treatment gains. Individuals will be randomized to a modified brief intervention incorporating with peer coaches, a standard brief intervention, or assessment only. Participants will be followed up at 3 and 6 mont... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
05/08/2025
Locations: Western Kentucky University, Bowling Green, Kentucky
Conditions: Alcohol Drinking, Substance Use, Drinking Behavior, Heavy Drinking
Adverse Adolescent Pathways to Substance Use
Recruiting
Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anxiety and their legal caregiver will be recruited from clinical and community sources. Procedures: Youth participants will complete several questionnaires and interviews, undergo neuroimaging while perf... Read More
Gender:
ALL
Ages:
Between 12 years and 14 years
Trial Updated:
05/08/2025
Locations: The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
Conditions: Anxiety, Adolescent Development, Substance Use
The Hastiin Bidziil (Strong Man) Intervention
Recruiting
The Hastiin Bidziil (Strong man) Intervention study is part of a larger project called, Community-Driven Indigenous Research, Cultural Strengths \& Leadership to Advance Equity in Substance Use Outcomes (CIRCLE) Center of Excellence. CIRCLE aims to address drug use related health problems in collaboration with diverse Indigenous communities. This study is a randomized controlled trial study to measure the effectiveness of a secondary prevention program, called Hastiin Bidziil (Strong Man), aimed... Read More
Gender:
MALE
Ages:
Between 18 years and 26 years
Trial Updated:
05/05/2025
Locations: Navajo Nation Center for Indigenous Health - Chinle, Chinle, Arizona +1 locations
Conditions: Substance Use
Recovery Finance: Financial Health and Mental Health After Incarceration
Recruiting
This proposal will address financial wellbeing, an often overlooked but important factor impacting reentry for justice-involved people with mental health challenges, who are disproportionately Black and Latine. The project will change community level determinants by integrating financial capability support (one-on-one coaching and access to financial tools and services) into existing services and training bank and credit union staff to reduce discrimination. It will also support collaborative co... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Yale University Program for Recovery and Community Health, New Haven, Connecticut
Conditions: Financial Hardship, Mental Health Issue, Substance Use
Ketamine for Methamphetamine Use Disorder
Recruiting
This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD.
The study design is a 12-week randomized, double-blind, controlled trial comparing intravenous (IV) ketamine against IV midazolam, delivered over six weeks in 120 adults with moderate to severe methamphetamine use disorder (MUD).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/25/2025
Locations: Interdisciplinary Substance Use and Brain Injury Facility, Albuquerque, New Mexico +3 locations
Conditions: Substance Use Disorders, Substance Use, Methamphetamine Abuse
Family Spirit Strengths
Recruiting
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in many of these communities. The investigators aim to address this gap by testing the effectiveness of a trans-diagnostic secondary prevention program, Family Spirit Strengths (FSS) that can be embedded within home visiting services. The FSS pr... Read More
Gender:
FEMALE
Ages:
14 years and above
Trial Updated:
04/15/2025
Locations: Johns Hopkins Center for Indigenous Health, Chinle, Arizona +2 locations
Conditions: Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
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