There are currently 69 active clinical trials seeking participants for HIV Infections research studies. The states with the highest number of trials for HIV Infections participants are California, New York, Florida and Texas.
Screen Smart: Using Digital Health to Improve HIV Screening and Prevention
NCT06003192
Recruiting
The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department (ED). The main question\[s\] it aims to answer are: 1. What is the uptake, reach and effectiveness of universally offered, opt-out HIV screening across pediatric EDs after implementing an adapted version of a tablet-based screening process? 2. What is the successful lin... Read More
Gender:
ALL
Ages:
Between 15 years and 21 years
Trial Updated:
04/30/2025
Locations: Nationwide Children's Hospital, Columbus, Ohio +3 locations
Conditions: HIV Infections
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A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes With and Without Ibalizumab
NCT05388474
Recruiting
The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical trials. This study will expand ibalizumab's clinical data set and allow a better understanding of the virologic response durability on ARV regimens with or without ibalizumab in a heterogeneous real-world patient population. Additional data on the efficacy and safety of ibalizumab and its impact on patient reported outcomes will be captured until study end. Primary Objective: To evaluate the long-term eff... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2025
Locations: Ruane Clinical Research, Los Angeles, California +35 locations
Conditions: HIV Infections, Multi-Antiviral Resistance
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Exploring, Predicting, and Intervening on Long-term Viral Suppression Electronically
NCT06370780
Recruiting
Despite the widespread availability of effective antiretroviral therapy (ART) in the United States, there remains significant numbers of people living with HIV (PLWH) who fail to achieve and or maintain viral suppression (VS). Disparities persist with the lowest levels of VS among Black individuals, people who use drugs, youth ages 18-24 and people residing in rural areas. Investigators will examine the syndemics underlying these outcomes including substance use, mental health, and barriers to H... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: HIV Infections
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A Study to Assess the Safety and Pharmacokinetics of a Human Monoclonal Antibody (VH4527079) in Healthy Adults and Persons With HIV
NCT06652958
Recruiting
This study evaluates the safety, tolerability, and pharmacokinetics (PK) of a single dose administration of VH4527079 by subcutaneous (SC) injection or by intravenous (IV) infusion in healthy adult participants and multiple dose administration by IV infusion in healthy adult participants and in Persons with HIV (PWH).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/07/2025
Locations: GSK Investigational Site, Las Vegas, Nevada +1 locations
Conditions: HIV Infections
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A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV
NCT07053384
Recruiting
This study investigates the use of VH3810109 with or without FTR to reduce the size and activity of the HIV viral reservoir in two sub-populations of people living with HIV: treatment-naïve adults (Population 1) and treatment-experienced adults currently taking a standard of care (SOC) integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) regimen (Population 2).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2025
Locations: GSK Investigational Site, Fort Pierce, Florida +1 locations
Conditions: HIV Infections
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In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
NCT04920539
Recruiting
In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/31/2025
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: HIV Infections, Healthy
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Feasibility of HPV Testing With Mail-delivered Sample Collection Kits
NCT07087145
Recruiting
People living with human immunodeficiency virus (PLWH) have an estimated 1.6-6.0 times increased risk of developing oropharyngeal cancer (OPC) compared with individuals in the general population. 70% of OPCs are caused by human papillomavirus (HPV), and PLWH also have an increased prevalence of oral HPV infection. Disparities by race/ethnicity also include a later stage of diagnosis and less frequent cancer-directed treatment for members of ethnic minority groups. There is little known regarding... Read More
Gender:
ALL
Ages:
35 years and above
Trial Updated:
07/29/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: HPV Infection, HIV Infections, HPV-Related Malignancy
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Infectious Disease (ID) Testing OUtreach in Carceral Hubs
NCT06679751
Recruiting
This pilot feasibility study represents part 3 of a larger R61 study, where the investigators will follow a cohort about their experiences with human immunodeficiency virus (HIV) testing. This project aims to assess the effectiveness of an intervention at two jail sites in the Boston area: South Bay House of Corrections and Nashua Street Jail implemented in January of 2025 that is aimed at improving HIV testing practices and HIV treatment in those carceral facilities. This implementation was de... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: South Bay House of Corrections, Boston, Massachusetts
Conditions: HIV Infections, Opioid Use Disorder
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Texting to Reduce Human Immunodeficiency Virus (HIV) Risk
NCT06088277
Recruiting
This is a 3-year study to test the efficacy of a text message-based intervention program. Dental patients at 4 community health centers (n= 266) will be randomized to receive either text messages (TMs) regarding HIV prevention or TMs regarding overall wellness. Prior to enrolling the 266 participants, the investigators will conduct a feasibility pilot (n=20) to test the TM delivery as well as all study procedures. For both the pilot and the randomized clinical trial (RCT), recruitment will be co... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: South End Community Health Center, Boston, Massachusetts +1 locations
Conditions: HIV Infections
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Advancing Access to HIV/HCV Testing for People Who Inject Drugs (PWID)
NCT06730555
Recruiting
The purpose of this study is to test the effectiveness of the ACCESS strategy: an organizational-level intervention that uses funding and practice facilitation to improve the organizational capacity of syringe services programs (SSPs) to implement routine, opt-out HIV and Hepatitis C (HCV) testing and linkage to care for people who inject drugs (PWID).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: University of Miami, Miami, Florida
Conditions: HIV Infections
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A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1
NCT06694805
Recruiting
This study will assess how effective, safe, and long-lasting a long-acting antiretroviral therapy (ART) using CAB LA + RPV LA is for people with HIV who still have detectable virus levels despite being on oral ART. The study will also consider feedback from patients on their experience with this treatment.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/16/2025
Locations: GSK Investigational Site, Birmingham, Alabama +59 locations
Conditions: HIV Infections
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Skeletal Muscle Energetics and Fatiguability in Older Individuals
NCT04142047
Recruiting
The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
07/09/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: HIV, HIV Infections
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