The city of Gainesville, Florida, currently has 7 active clinical trials seeking participants for Osteoarthritis research studies.
Understanding Cognition, Oxytocin & Pain in Elders
NCT03878589
Recruiting
Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in animal and human studies. This proposal will test the efficacy and safety of self-administered intranasal OT over 4-weeks in older individuals relative to placebo (P) evaluating its effects on pain and function in aging and testing potential underlying neurobiological mechanisms.
Gender:
All
Ages:
Between 45 years and 100 years
Trial Updated:
04/23/2024
Locations: Department of Community Dentistry and Behavioral Science, Gainesville, Florida +1 locations
Conditions: Knee Osteoarthritis, Osteoarthritis
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A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
NCT04504812
Recruiting
There is an urgent public health need to reduce reliance on opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA). This effectiveness trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA.These results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Knee Osteoarthritis
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Exactech Shoulder Post Market Clinical Follow-up Study
NCT05603728
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
All
Ages:
21 years and above
Trial Updated:
02/23/2024
Locations: UF Health Orthopaedics and Sports Medicine Institute, Gainesville, Florida
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
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Study of Pain Catastrophizing-2 (SPAC-2)
NCT04805190
Recruiting
This study experimentally manipulates pain catastrophizing in order to investigate the neural mechanisms by which pain catastrophizing influences the experience of pain in different ethnic groups among adults with knee osteoarthritis. Participants will be randomized to either a single session cognitive-behavioral intervention to reduce pain catastrophizing or a pain education control group.
Gender:
All
Ages:
Between 45 years and 85 years
Trial Updated:
12/05/2023
Locations: UF Health at the University of Florida, Gainesville, Florida
Conditions: Osteoarthritis, Knee
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Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
NCT03884374
Recruiting
This mechanistic clinical trial proposes to test whether a five-day course of mindfulness meditation training (MMT) and tDCS, and their combination, can enhance pain modulatory balance and pain-related brain function, reduce clinical pain, among African Americans and non-Hispanic whites with knee osteoarthritis (OA). This approach will provide evidence that targeting stress and pain-related brain function will reduce OA-related pain and ethnic group differences therein.
Gender:
All
Ages:
Between 45 years and 85 years
Trial Updated:
09/18/2023
Locations: University of Florida, Gainesville, Florida
Conditions: Osteoarthritis of Knee
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Clinical Orthopaedic Data Bank (Acute and Chronic)
NCT00411060
Recruiting
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.
Gender:
All
Ages:
All
Trial Updated:
07/24/2023
Locations: UF&Shands Orthopaedics and Sports Medicine Institute, Gainesville, Florida
Conditions: Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
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Thumb Osteoarthritis Mechanisms
NCT04104477
Recruiting
This study examines carpometacarpal osteoarthritis (CMC OA) and aims to elucidate the biomechanical, neuromuscular, and somatosensory mechanisms that contribute to CMC OA symptoms by using orthopaedic biomechanics and quantitative pain testing. Completion of this study will provide a comprehensive dataset describing how movement strategies (muscle activity and joint posture) as well as experimental and clinical pain differ between individuals with CMC OA and age-matched controls.
Gender:
Female
Ages:
Between 40 years and 90 years
Trial Updated:
11/21/2022
Locations: UF Health of University of Florida, Gainesville, Florida
Conditions: Carpometacarpal Osteoarthritis
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