The state of Illinois currently has 44 active clinical trials seeking participants for Arthritis research studies. These trials are conducted in various cities, including Chicago, Peoria, Springfield and Urbana.
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
Recruiting
The goal of this study is to create a prospective registry (\<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2025
Locations: University of Chicago Duchossois Center for Advanced Medicine, Chicago, Illinois
Conditions: Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb
Recruiting
Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other, there is no consensus on the optimal duration of postoperative immobilization. Immobilization following surgery is critical for wound healing, pain control, and aid with activities of daily living in the early recovery period, though the duration of this must be weighed against the negative impacts... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/13/2025
Locations: University of Chicago Medicine, Chicago, Illinois
Conditions: Thumb Osteoarthritis
Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
Recruiting
The purpose of this trial is to investigate the efficacy and safety of dapansutrile (OLT1177®) tablets in subjects with an acute gout flare.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Great Lakes Clinical Trials, Chicago, Illinois +1 locations
Conditions: Acute Gout Flare, Gout Attack, Gout Flare, Gouty Arthritis, Gout, Arthritis, Joint Pain
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Recruiting
This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/25/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Rheumatoid Arthritis
Efficacy of Intra-articular Injections for the Treatment of Primary Glenohumeral Osteoarthritis(GHOA)
Recruiting
The purpose of this study is to compare the efficacy of intra-articular corticosteroid injections versus platelet-rich plasma injections for non-operative treatment of primary glenohumeral osteoarthritis. The efficacy of intra-articular injections, outside of hyaluronic acid, for the treatment of glenohumeral OA is not known, yet these treatments are commonly used with hopes of providing patients with symptomatic relief that can hopefully delay or prevent the need for shoulder arthroplasty. This... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Arthritis Shoulder
Mechanical Alignment Vs Kalipered Kinematic Alignment Total Knee Arthroplasty
Recruiting
Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical Alignment (MA). The neutral position is different than the human knee's natural position, so MA often requires the surgeon to make additional cuts to the ligaments and other soft tissue around the knee. More recently surgeons have started to place the new joint in a position that more closely repli... Read More
Gender:
ALL
Ages:
Between 21 years and 79 years
Trial Updated:
09/25/2024
Locations: Northwestern Medicine, Chicago, Illinois
Conditions: Knee Osteoarthritis, Knee Arthropathy
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Recruiting
Prospective single-masked (study participant will be masked), randomized controlled trial to examine the influence of BMAC on patient-reported outcomes (PROs) in patients with primary knee osteoarthritis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Osteoarthritis of the Knee
Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis
Recruiting
This randomized pragmatic trial will generate knowledge about strategies used to de-escalate tumor necrosis factor inhibitor (TNFi) therapy in patients with juvenile spondyloarthritis with sustained inactive disease and are treated at one of the 29 participating pediatric healthcare systems. This open label study will be conducted in the setting of routine clinical care and will compare the risk and timing of flare (Aim 1) and patients' lived experiences (Aim 2) across three arms.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
08/02/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Juvenile Spondyloarthritis
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
Recruiting
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have an Xray, knee MRI, brain MRI, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to... Read More
Gender:
ALL
Ages:
41 years and above
Trial Updated:
07/23/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Knee Osteoarthritis
Knee Arthroplasty Activity Trial
Recruiting
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA). As of 2013, the annual incidence of TKR was over 680,000 surgeries and annual costs exceeded $11 billion. Growing evidence suggests that while pain and functional status improve following TKR, physical activity (PA) typically does not surpass pre-TKR levels. Engagement in PA can meaningfully improve quality of life (QoL), p... Read More
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
04/15/2024
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Knee Osteoarthritis, Total Knee Replacement
Dronabinol After Arthroscopic Surgery
Recruiting
The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee. The investigators hypothesize that dronabinol will relieve pain, reduce opioid consumption and will result in few negative side effects. If this pilot study shows promising results the investigators will expand the trial to include additional arthroscopic surgeries (hip, shoulder) and other types of orthopaedic surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Northwestern University Feinberg School of Medicine, Chicago, Illinois
Conditions: Knee Osteoarthritis, Knee Injuries, Meniscus Tear, Synovitis of Knee, Knee Ligament Injury, Chondral Injury of Left Knee, Chondral Injury of Right Knee, Loose Body Knee
Chronic Pain in Rheumatoid Arthritis
Recruiting
The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Arthritis, Rheumatoid, Pain