The state of Illinois currently has 41 active clinical trials seeking participants for Arthritis research studies. These trials are conducted in various cities, including Chicago, Peoria, Springfield and Urbana.
GAE Using Embosphere Microspheres Vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
Recruiting
This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using Embosphere Microspheres or steroid injection over a period of 24 months.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
08/28/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Knee Osteoarthritis
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Recruiting
Prospective single-masked (study participant will be masked), randomized controlled trial to examine the influence of BMAC on patient-reported outcomes (PROs) in patients with primary knee osteoarthritis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Osteoarthritis of the Knee
Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis
Recruiting
This randomized pragmatic trial will generate knowledge about strategies used to de-escalate tumor necrosis factor inhibitor (TNFi) therapy in patients with juvenile spondyloarthritis with sustained inactive disease and are treated at one of the 29 participating pediatric healthcare systems. This open label study will be conducted in the setting of routine clinical care and will compare the risk and timing of flare (Aim 1) and patients' lived experiences (Aim 2) across three arms.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
08/02/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Juvenile Spondyloarthritis
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
Recruiting
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have an Xray, knee MRI, brain MRI, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to... Read More
Gender:
ALL
Ages:
41 years and above
Trial Updated:
07/23/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Knee Osteoarthritis
Knee Arthroplasty Activity Trial
Recruiting
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA). As of 2013, the annual incidence of TKR was over 680,000 surgeries and annual costs exceeded $11 billion. Growing evidence suggests that while pain and functional status improve following TKR, physical activity (PA) typically does not surpass pre-TKR levels. Engagement in PA can meaningfully improve quality of life (QoL), p... Read More
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
04/15/2024
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Knee Osteoarthritis, Total Knee Replacement
Autologous Bone Marrow Aspirate Concentrate in Patients Undergoing Meniscectomy
Recruiting
The proposed research study aims to evaluate the effects of autologous bone marrow aspirate concentrate (BMAC) on the development and progression of osteoarthritis (OA) in patients undergoing meniscectomy. This prospective, randomized, double-blind clinical trial will compare patient-reported outcomes, specifically IKDC scores between patients who receive BMAC post-meniscectomy and those who receive a saline control injection. The study will also compare physical examination, MRI, radiographs, a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Osteoarthritis Post-meniscectomy
Dronabinol After Arthroscopic Surgery
Recruiting
The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee. The investigators hypothesize that dronabinol will relieve pain, reduce opioid consumption and will result in few negative side effects. If this pilot study shows promising results the investigators will expand the trial to include additional arthroscopic surgeries (hip, shoulder) and other types of orthopaedic surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Northwestern University Feinberg School of Medicine, Chicago, Illinois
Conditions: Knee Osteoarthritis, Knee Injuries, Meniscus Tear, Synovitis of Knee, Knee Ligament Injury, Chondral Injury of Left Knee, Chondral Injury of Right Knee, Loose Body Knee
Chronic Pain in Rheumatoid Arthritis
Recruiting
The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Arthritis, Rheumatoid, Pain
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
Recruiting
This is a single-center, prospective, randomized, single-blind, comparator therapy, parallel group study for symptomatic patients diagnosed with knee osteoarthritis. The aim is to demonstrate superior efficacy of platelet-rich plasma (PRP) as compared to hyaluronic acid (HA) in treating knee osteoarthritis. This aim will be objectively measured by endpoint consisting of changes in cartilage thickness from baseline in the MRI. The Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/23/2024
Locations: NorthShore University HealthSystems, Skokie, Illinois
Conditions: Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Recruiting
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Chicago Clinical Research Institute Inc., Chicago, Illinois +2 locations
Conditions: Knee Osteoarthritis
The Impact of a Seated Compact Elliptical Trainer on Individuals With Knee OA
Recruiting
Exercise is considered the most effective, non-drug treatment for reducing pain and improving movement in patients with osteoarthritis. Diminished muscle strength is a common symptom associated with the onset of knee osteoarthritis. The evidence supports the benefit of exercise therapy, in reducing pain and improving function in subjects with knee OA, however research to date has been unable to quantify the disease-modifying effect of any form of exercise. The primary objective of this study is... Read More
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
05/11/2023
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Osteoarthritis, Knee Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
Impact of Different Exercise Programs on Knee OA
Recruiting
This study will examine and compare the changes in serum biomarkers, joint kinematics, and thigh muscle strength based on three different 8-week exercise protocols in individuals with knee pathology: Lower-body positive-pressure (LBPP) supported low-load treadmill walking and Aquatic exercise program and standard of care treadmill or community walking. Investigators hypothesize that both the 8-week exercise programs which aim to partially off-load the knee joint will be associated with a signif... Read More
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
05/02/2023
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Osteoarthritis, Knee Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases