The state of Indiana currently has 22 active clinical trials seeking participants for Asthma research studies. These trials are conducted in various cities, including Indianapolis, South Bend, Fort Wayne and Evansville.
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
Recruiting
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) trial, to follow the offspring through 10 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can signifi... Read More
Gender:
All
Ages:
Between 6 years and 16 years
Trial Updated:
11/17/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype
Recruiting
This study will assess whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 (Depemokimab) is non-inferior to maintaining current treatment on the annualized rate of clinically significant exacerbations in participants with severe asthma with an eosinophilic phenotype. Throughout the study, all participants will continue their non-biologic Baseline standard of care (SoC) asthma treatment.
Gender:
All
Ages:
12 years and above
Trial Updated:
11/06/2023
Locations: GSK Investigational Site, Evansville, Indiana
Conditions: Asthma
Vitamin C Supplementation to Pregnant Smokers: Follow-up of 2 Randomized Trials Plus Changes in DNA Methylation
Recruiting
In a randomized clinical trial (RCT) published in JAMA, the investigators have provided evidence that vitamin C supplementation (500 mg daily during pregnancy) ameliorates the effects of maternal smoking during pregnancy on offspring lung function and subsequent incidence of wheeze by 48% through 1 year of age. The investigators are currently completing a second RCT of vitamin C supplementation in pregnant smokers with more robust measures of pulmonary outcomes. The purpose of this ECHO applicat... Read More
Gender:
All
Ages:
Between 6 months and 11 years
Trial Updated:
10/06/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Asthma, Wheezing, In Utero Nicotine, Pulmonary Function
VCSIP Follow-up Study
Recruiting
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring. This is a continuation of the VCSIP trial, to follow the offspring through 5 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's PFTs and decrease the incidence of wheeze.
Gender:
All
Ages:
Between 6 months and 4 years
Trial Updated:
10/03/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
Evaluate Pharmacokinetics and Safety of Slow Release DHEA
Recruiting
This is a study to look at pharmacokinetic levels of different doses of slow release DHEA in subjects with severe asthma.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
09/28/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana +1 locations
Conditions: Asthma, Genotype
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
All
Ages:
Between 0 years and 20 years
Trial Updated:
09/21/2023
Locations: Riley Hospital for Children at Indiana University, Indianapolis, Indiana
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
Project 2 Airway Potential Hydrogen (pH) in Asthma
Recruiting
This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug. The airway pH will help health care providers in creating tailored treatment plans for individuals suffering from these specific conditions.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2023
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Cystic Fibrosis, Asthma, Severe Persistent Asthma, Healthy
5HTP Regulation Of Asthma In Children
Recruiting
The purpose of this study is to learn more about if taking a supplement called 5-hydroxytryptophan (5HTP) can improve breathing and anxiety symptoms related to asthma. To help learn more subjects will either be assigned to a group that is taking the supplement (5HTP) or a group that is taking a placebo. This will be decided randomly. Later in the study subjects will crossover to the other group.There are 5 study visits over the course of about 12 weeks.
Gender:
All
Ages:
Between 8 years and 18 years
Trial Updated:
05/17/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Mild or Moderate Asthma With Allergic Sensitization
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Asthma
GSNOR Phenotyping/GSNO Challenge in Severe Asthma
Recruiting
Asthma is caused by or worsened by different things in different people. It is because of these differences that not all people with asthma respond the same to all treatments and medicines. If the investigators can better identify the changes in the airways or breathing pipes in patients with asthma, the investigators may be able to help patients make better choices about the medicines or treatments that are most likely to work best for each patient. This research study is about one specific fa... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
02/28/2023
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Asthma, Healthy Volunteers