SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study
NCT04054401
Recruiting
The purpose of the study is to evaluate the safety and tolerability of DRG stimulation when placing a neurostimulator during the same procedure as implantation of spinal fixation with or without interbody cage systems in patients with chronic back and/or leg pain requiring single level spinal fusion.
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
11/21/2023
Locations: South Bend Orthopaedics, Mishawaka, Indiana
Conditions: Spinal Fusion, Radiculopathy Lumbar, Chronic Pain
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RELIEF - A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
NCT01719055
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use - and - To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Global Scientific Innovations - Advanced Pain Care Clinic, Evansville, Indiana +3 locations
Conditions: Pain
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Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
NCT05740007
Recruiting
The aim of this study is to assess whether IW-3300 is safe and works for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). The main question the study aims to answer is whether IW-3300 helps bladder pain and other symptoms (for example, bladder burning, pressure and discomfort). Subjects will be assigned to receive either the study drug or placebo by chance.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/15/2023
Locations: First Urology PSC, Jeffersonville, Indiana
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
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Patient Retrospective Outcomes (PRO)
NCT01550575
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/14/2023
Locations: Summit Research Institute, Fort Wayne, Indiana +1 locations
Conditions: Chronic Pain
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Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
NCT03876054
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/10/2023
Locations: Goodman Campbell Brain and Spine, Indianapolis, Indiana
Conditions: Chronic Pain
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QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
NCT03434392
Recruiting
Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to map the pain system. QST has the potential to change and improve the treatment paradigm for patients with CP and may eventually be able to predict response to invasive CP therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/07/2023
Locations: Indiana University Medical Center, Indianapolis, Indiana
Conditions: Chronic Pancreatitis, Chronic Pain
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iFuse TORQ for the Treatment of Sacroiliac Joint Dysfunction
NCT05870488
Recruiting
STACI is a prospective, multicenter, study of SIJ fusion using the iFuse TORQ implant system.
Gender:
All
Ages:
21 years and above
Trial Updated:
11/02/2023
Locations: Comprehensive Pain and Spine Specialists, Shelbyville, Indiana
Conditions: Sacroiliac Joint Dysfunction, Sacroiliac; Fusion, Sacroiliac Disorder, Sacroiliac Joint Pain
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Paresthesia-Free Fast-Acting Subperception (FAST) Study
NCT04618471
Recruiting
Study to evaluate the effectiveness of FAST-SCS (fast-acting paresthesia-free therapy) and additional SCS therapy options in patients with chronic pain using Boston Scientific WaveWriter SCS Systems.
Gender:
All
Ages:
22 years and above
Trial Updated:
11/02/2023
Locations: Goodman Campbell Brain and Spine, Carmel, Indiana
Conditions: Chronic Pain
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Options for Pain Management Using Nonpharmacological Strategies
NCT05563792
Recruiting
The purpose of this study is to help Veterans learn about different ways they can manage chronic pain that do not involve medications. Veterans will work with a coach to explore the Veterans' values and goals and how different non-medication approaches may fit into these values and goals.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis, Indiana
Conditions: Pain
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A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: Brengle Family Medicine, Indianapolis, Indiana
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
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Freedom-1 Study for Chronic Knee Pain
NCT03877653
Recruiting
To demonstrate the potential benefits and risk of active sub-threshold stimulation in the treatment of chronic knee pain as compared to subjects that did not have active stimulation. Improvement will be assessed in relation to the clinical outcome measures of pain, with primary endpoint; Pain relief rate as measured by the number of subjects with greater or equal to a 50% decrease in pain on the visual analog scale, comparing baseline to the 1-month follow-up.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: Global Scientific Innovations LLC, Evansville, Indiana
Conditions: Osteoarthritic Knee Pain
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STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
NCT05603702
Recruiting
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP). This pilot trial will test the feasibility of the study design and provide reassurance regarding the tolerability and safety of lacosamide used concomitantly with opioids in this patient population to reduce the condition known clinically as opioid-induced hyperalgesia (OIH).
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia, Opioid Use Disorder, Opioid-Related Disorders, Opioid Dependence, Chronic Abdominal Pain, ERCP, Pancreatic Surgery
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