The state of Kentucky currently has 3 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Louisville, Lexington, Owensboro and Paducah.
Maintenance TMS in Treatment Resistant Depression
Recruiting
Electroconvulsive therapy (ECT) is one of the most efficacious treatments available for treatment-resistant depression (TRD). Although a maintenance ECT protocol exists, multiple barriers limit its use for long-term use. These barriers include procedure tolerability, cognitive side effects, financial burden, and unreliable social support to accompany patients for these treatments. On the other hand, a different modality of noninvasive neuromodulation called transcranial magnetic stimulation (TMS... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/02/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Treatment Resistant Depression (TRD)
A Precision Medicine Approach to Target Engagement for Emotion Regulation
Recruiting
The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Emotional Regulation, Depression, Anxiety, Borderline Personality Disorder, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Eating Disorders
Antidepressant Discontinuation in Treatment Resistant Depression
Recruiting
The purpose of this study is to compare the effects on depressive symptoms of subjects who discontinue serotonergic antidepressants (a certain type of antidepressant, such as Prozac, that works on serotonin receptors in the brain) with the effects on depressive symptoms of subjects who continue to take serotonergic antidepressants. During this study, subjects will also be presented with the opportunity to undergo genetic testing for the serotonin gene transporter which has a short or long form.... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/16/2023
Locations: University of Louisville, Department of Psychiatry and Behavioral Sciences, Louisville, Kentucky
Conditions: Treatment Resistant Depression