There are currently 545 clinical trials in Lexington, Kentucky looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Kentucky, University of Kentucky/Markey Cancer Center, Saint Joseph Hospital East and Baptist Health Lexington. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Collecting and Storing Tissue From Young Patients With Cancer
NCT00898755
Recruiting
This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
Gender:
All
Ages:
21 years and below
Trial Updated:
01/29/2024
Locations: University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Conditions: Acute Lymphoblastic Leukemia, Rhabdomyosarcoma, Acute Myeloid Leukemia, Central Nervous System Neoplasm, Ewing Sarcoma, Germ Cell Tumor, Leukemia, Lymphoma, Malignant Neoplasm, Neuroblastoma, Osteosarcoma, Retinoblastoma, Rhabdoid Tumor, Soft Tissue Sarcoma
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Neoadjuvant Endocrine Therapy in ER-positive, HER2-negative Early Stage Breast Cancer
NCT05150652
Recruiting
The goal of this study is to access whether treatment of early state estrogen-rich breast cancers with neoadjuvant endocrine therapy will result in higher rates of margin negativity on lumpectomy specimen.
Gender:
Female
Ages:
Between 18 years and 99 years
Trial Updated:
01/26/2024
Locations: University of Kentucky Markey Cancer Center, Lexington, Kentucky
Conditions: Breast Cancer, HER2-negative Breast Cancer, Node-negative Breast Cancer, Breast Carcinoma
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
All
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: NASH - Nonalcoholic Steatohepatitis
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A Causative Role for Amylin in Diabetic Peripheral Neuropathy
NCT03481283
Recruiting
Three pieces of information lead to the basis for this study: Individuals with Type-2 diabetes commonly develop peripheral neuropathy. Increased production of the hormone amylin occurs in individuals who have Type-2 diabetes. Aggregations of amylin was found in the peripheral vasculature of rats that overexpressed human amylin. The purpose of this study is to determine whether a correlation exists between the amount of amylin present in the upper extremities of human subjects with Type-2 diabe... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: UK Robert Straus Behavioral Science Laboratory, Lexington, Kentucky +1 locations
Conditions: Type2 Diabetes, Peripheral Neuropathy
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STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
NCT03935750
Recruiting
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the articular cartilage and increased rates of meniscal tears, increasing the risk of post-traumatic osteoarthritis (PTOA), additional surgical procedures, reduced physical function and qua... Read More
Gender:
All
Ages:
Between 14 years and 25 years
Trial Updated:
01/22/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
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TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.
NCT02980029
Recruiting
Primary Objective • To evaluate the pharmacodynamic effects on metabolic endpoints (malonyl carnitine and tripalmitin levels) following short-term treatment with TVB-2640 in patients with resectable cancers Secondary Objectives To determine if short-term treatment with TVB-2640 decreases cancer cell proliferation. To examine other biological endpoints and determine if TVB-2640 inhibits cell survival signaling and lipid biogenesis. To perform comprehensive metabolomic analysis in tumor tissues... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
01/18/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Colon Cancer
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Ankle Instability Using Foot Intensive Rehabilitation
NCT04493645
Recruiting
The overall objective of this study is to examine the effects of a 6-week foot-intensive rehabilitation (FIRE) program on lateral ankle sprain (LAS) re-injury rates, CAI symptoms, sensorimotor function, and self-reported disability in CAI patients.
Gender:
All
Ages:
Between 18 years and 44 years
Trial Updated:
01/18/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Ankle Injuries, Ankle Sprains
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Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
NCT02493478
Recruiting
Advanced airway interventions are common high risk, high stakes events for children in intensive care units (ICU) and emergency departments (ED), with risk for life and health threatening consequences.
Gender:
All
Ages:
All
Trial Updated:
01/17/2024
Locations: Kentucky Children's Hospital, Lexington, Kentucky
Conditions: Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication
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A Study Assessing Corneal Endothelial Cells in Patients With Neovascular Age-related Macular Degeneration Treated With the Port Delivery System With Ranibizumab (PDS)
NCT04853251
Recruiting
This study will assess corneal endothelial cells in patients with neovascular age-related macular degeneration (nAMD) treated with Port Delivery System with ranibizumab (PDS) refilled every 24 weeks (Q24W)
Gender:
All
Ages:
50 years and above
Trial Updated:
01/16/2024
Locations: Retina Associates of Kentucky, Lexington, Kentucky
Conditions: Neovascular Age-related Macular Degeneration
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Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
NCT02089217
Recruiting
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical ma... Read More
Gender:
All
Ages:
Between 35 years and 100 years
Trial Updated:
01/12/2024
Locations: Baptist Health Lexington, Lexington, Kentucky +1 locations
Conditions: Carotid Stenosis
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Multilevel HPV Self-Testing Intervention for the Increase of Cervical Cancer Screening Among Women in Appalachia
NCT04411849
Recruiting
This trial studies how well a multilevel human papillomavirus (HPV) self-testing intervention works in increasing cervical cancer screening among women in Appalachia. Most cases of cervical cancer occur among unscreened and underscreened women. A multilevel HPV self-testing intervention may help to improve cervical cancer screening rates.
Gender:
Female
Ages:
Between 30 years and 64 years
Trial Updated:
01/12/2024
Locations: University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Conditions: Cervical Carcinoma, Human Papillomavirus Infection
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Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder
NCT05049460
Recruiting
The goal of this study is to examine the effect of four sessions of theta burst stimulation (TBS) versus sham TMS on attentional bias for smoking and opioid cues versus neutral stimuli in a population of patients with tobacco use disorder (TUD) with comorbid opioid use disorder (OUD) that is stable and on treatment with buprenorphine. The investigators will also examine the effect of TBS on craving for cigarettes as well as opioids. Participants will perform a stress induction procedure that mir... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/11/2024
Locations: 245 Fountain Court, Lexington, Kentucky
Conditions: Opioid-use Disorder, Tobacco Use Disorder
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