The state of Maryland currently has 59 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Baltimore, Bethesda, Rockville and Annapolis.
Natural History of Sickle Cell Disease
Recruiting
This study is not a treatment protocol and no experimental treatments are involved. Study participants may be seen as needed for clinical, translational and basic research studies, or as medically indicated. Subjects will receive their general medical care outside the NIH and will be seen at our clinic or at CNHS with varying frequency. Subjects may be seen for multiple visits. Subjects may be asked to return for additional testing as needed. Clinical care for patients with sickle cell disease w... Read More
Gender:
ALL
Ages:
Between 2 years and 90 years
Trial Updated:
07/31/2025
Locations: Suburban Hospital, Bethesda, Maryland +1 locations
Conditions: Pain Crisis
State-dependent Interoception, Value-based Decision-making, and Introspection
Recruiting
Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how emotions affect thinking and behavior in healthy people, researchers hope to better understand how to identify and treat people with mental disorders. Objective: To learn how negative emotions affe... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Stress, Pain, Emotions, Craving, Frustration
Neural and Psychological Mechanisms of Pain Perception
Recruiting
Background: - Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect different levels of pain and receive treatments that can modify pain. They want to see if these factors influence decisions about pain and how the body responds to it. They also want to compare pain with resp... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pain, Normal Physiology, Healthy Volunteers
Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain
Recruiting
Background: - Researchers are interested in how the muscles affect the movement of the knee cap. These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease. Imaging studies such as magnetic resonance imaging (MRI) can be used to look at these muscles. To study these muscles and how they move, researchers will use MRI to look at healthy individuals and individuals with knee cap pain. Objectives: - To study how changes to the muscles around the kn... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Patellofemoral Pain Syndrome
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Recruiting
Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symptoms, including pain. Pain is the number one reason individuals seek medical treatment. Health disparities in pain encompass both differences in pain experience and treatment for pain. For instance, r... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal Physiology, Healthy Volunteers, Pain
Photobiomodulation and Tooth Analgesia
Recruiting
The purpose of this study is to test photobiomodulation (PBM) with a non-invasive light device for reducing discomfort during dental treatments in children. We plan to conduct a series of three clinical studies in 200 school-aged children requiring routine dental treatment. The first study aims to test if PBM works for tooth and soft tissue by assessing response to cold testing and probing of gums. The second study aims to test if use of PBM on soft tissues before injection reduces discomfort. T... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
07/21/2025
Locations: University of Maryland School of Dentistry, Pediatric Clinics, Baltimore, Maryland
Conditions: Dental Anaesthesia, Dental Pain, Dental Analgesia
Randomized Blinded Evaluation of the Effects of TENS and IFC Compared to a Sham Device and SOC in Patients With Non-Specific CLBP
Recruiting
This is a prospective, sham-controlled, randomized, single-blinded, multi-center study comparing two different modes of the NexWave device, transcutaneous electrical nerve stimulation (TENS) and interferential current (IFC), with an identical non-functioning NexWave sham device or self-defined standard of care for improvement of pain intensity of non-specific CLBP.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/17/2025
Locations: CAO Research Foundation, Catonsville, Maryland
Conditions: Non-Specific Chronic Lower Back Pain
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
Recruiting
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: MedStar, Baltimore, Maryland
Conditions: Acute Pain
Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
Recruiting
The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2025
Locations: Spine and Joint Institute, Glen Burnie, Maryland
Conditions: Chronic Pain
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
Recruiting
The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma. As part of this study, participants will be asked to attend weekly EAET treatment sessions and complete assessments (including pre-treatment, post-treatment, and follow-up) consisting of questionnaires and sensory testing procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2025
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Orthopaedic Trauma, Chronic Pain, Musculoskeletal Injury
Patient Retrospective Outcomes (PRO)
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2025
Locations: Pain and Spine Specialist of Maryland, Mount Airy, Maryland
Conditions: Chronic Pain
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
Recruiting
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv). The research study is testing two different interventions along with usual clinical care: 1. Pain Self-Management (PSM): an educational program in which individuals with chronic pain work with a trained pain coach and a pain peer to explore strategies to effectively manage the daily problems that arise from chronic pain. 2. Patient-Oriented Dosing (POD):... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Alcohol and Drug Abuse Program (ADAP) - UM Addiction Treatment Center, Baltimore, Maryland +2 locations
Conditions: Opioid Use Disorder, Chronic Pain