The state of Maryland currently has 49 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Baltimore, Bethesda, Rockville and Annapolis.
Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy
Recruiting
This clinical study is a randomized, double-blind, double-dummy, parallel group, multi-center, active and placebo-controlled trial evaluating the analgesic efficacy and safety of NTM-001 in subjects with moderately severe postoperative pain after bunionectomy surgery. This study is designed to compare the efficacy of NTM-001 to placebo. Intravenous (IV) morphine serves as an active comparator to determine assay sensitivity and support assessment of opioid-level analgesia for NTM-001. Effectiven... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
10/25/2023
Locations: Chesapeake Research, Pasadena, Maryland
Conditions: Pain, Postoperative
State-dependent Interoception, Value-based Decision-making, and Introspection
Recruiting
Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how emotions affect thinking and behavior in healthy people, researchers hope to better understand how to identify and treat people with mental disorders. Objective: To learn how negative emotions affe... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
10/25/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Stress, Pain, Emotions, Craving, Frustration
Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery
Recruiting
Cryotherapy has been used to enhance recovery after orthopaedic surgery. Many devices are available but few can guarantee a temperature regulation during a prolonged time and therefore have been criticized. The arrival of new advanced cryotherapy devices made it possible to test the effect of prolonged cooling on rehabilitation after arthroscopic orthopaedic procedures.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Cryotherapy Effect, Compression, Postoperative Pain Management
Comparing Platelet Rich Plasma and Corticosteroid for Military & Civilian Patients With Glenohumeral Osteoarthritis
Recruiting
Shoulder arthroplasty provides successful improvement in pain and function for the treatment of end stage osteoarthritis (OA) of the shoulder in the older patient population (Sanchez 2008, Sampson 2010, Kon 2012, Fitzpatrick 2017). However, the optimal non-operative treatment for shoulder OA in the young active duty and civilian populations has yet to be determined. Although corticosteroid injections (CSI) are a viable option with diagnostic and short-term therapeutic benefit in glenohumeral OA,... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
10/19/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Osteoarthritis of the Shoulder, Corticosteroid, PRP, Pain
A Novel Device for Neck Pain in Active-duty Military Personnel With Forward Head Posture.
Recruiting
Neck pain is a common complaint among active duty military personnel, and can have tremendous impacts on quality of life and participation in duty-related activities. Treatments for spinal pain in military personnel are typically multimodal, relying upon physical therapy, pharmacological agents, spinal manipulation, and psychotherapy. However, there does not exist a wide body of evidence to support many of these treatments in active-duty military. The Cervigard neck collar was designed to treat... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
10/04/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Neck Pain
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
All
Ages:
Between 0 years and 20 years
Trial Updated:
09/21/2023
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
Effects of External Ear Stimulation on Pain Perception and Mood
Recruiting
Background: The vagus nerve runs from the brain to many organs. Stimulating it can affect the experience of pain. The nerve can be stimulated on the surface of the left ear. Researchers want to study how this stimulation affects the perception of pain. They also want to study how mood affects the experience of pain. Objective: To study the effects of mood and vagus nerve stimulation on the experience of pain. Eligibility: Healthy people ages 18 and older who are fluent in English Design:... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
09/16/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pain in Healthy Participants
Neural Correlates of Hypoalgesia Driven by Observation
Recruiting
Placebo effects held an ambivalent place in health care for at least two centuries. On the one hand, placebos are traditionally used as controls in clinical trials to correct for biases and the placebo response is viewed as an effect to be factored out in order to isolate and accurately measure the effects of the treatment. On the other hand, there is scientific evidence that placebo effects represent fascinating psychoneurobiological events involving the contribution of distinct central nervous... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/11/2023
Locations: University of Maryland, Baltimore, Maryland
Conditions: Pain, Virtual Reality, Placebo
Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes
Recruiting
The investigators aim to determine whether cervical paravertebral muscle twitching during motor testing as part of performing cervical RFAs is associated with a greater likelihood of treatment success, and greater magnitude or duration of analgesia. The investigators propose a straightforward grading scale based on visual and tactile information readily available during RFA procedures as part of routine practice (per radiofrequency electrode: 0 = no twitches palpated or observed; 1 = twitches pa... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/11/2023
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Cervical Facet Joint Pain, Chronic Pain, Neck Pain
Transvaginal Low-level Laser Therapy to Improve Pelvic Pain and Sexual Function in Patients With Endometriosis.
Recruiting
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with endometriosis have a nine-fold increased risk of dyspareunia, when compared to the general female population. A prospective single-blinded randomized controlled trial will be performed evaluating the change in pelvic pain and sexual satisfaction scores from baseline to 6 weeks after treatment with transvaginal photobiomodulation therapy or sham therapy. Treatment will involve 9 planned treatment sessions over 3-4 wee... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
09/01/2023
Locations: MedStar Mitchellville Clinic, Mitchellville, Maryland +1 locations
Conditions: Endometriosis, Dyspareunia, Pelvic Pain
Assessing Ketorolac (Toradol) at Oocyte Retrieval
Recruiting
To determine if a nonsteroidal anti-inflammatory drug (NSAID), Ketorolac (Toradol), can improve pain control and decrease narcotic use after undergoing egg retrieval.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
08/30/2023
Locations: Shady Grove Fertility Reproductive Science Center, Rockville, Maryland
Conditions: Infertility, Infertility, Female, Oocyte Retrieval, Postoperative Pain, Embryo Transfer
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Recruiting
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain and spine injury correlates of pain and sensory deficits.
Gender:
All
Ages:
8 years and above
Trial Updated:
08/18/2023
Locations: F.M. Kirby Center, Baltimore, Maryland +3 locations
Conditions: Cerebral Palsy, Chronic Pain