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Arthritis Clinical Trials in Boston, MA
A listing of 22 Arthritis clinical trials in Boston, MA actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 22
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Clinical Trial Phase
The city of Boston, Massachusetts, currently has 22 active clinical trials seeking participants for Arthritis research studies.
Featured Trial
Rheumatoid Arthritis (RA) Clinical Research Study
Recruiting
The Ntrust-2 study is a clinical research study evaluating an investigational cell therapy, called NKX019, in adults living with rheumatoid arthritis (RA).
The Ntrust-2 study
The Ntrust-2 study is part of a broad effort of the global research community to develop more treatment options for people living with rheumatoid arthritis.
What is NKX019?
NKX019 is an investigational cell therapy being studied for rheumatoid arthritis (RA). It is designed to target and remove the cells that may trigger harmful antibodies, which attack the body’s own tissues in these conditions.
Who can join this study?
You may be eligible to participate in this study if you:
- Are 18 to 75 years old
- Have been diagnosed with rheumatoid arthritis (RA)
- Have received prior autoimmune disease treatments that may have not worked well for you
Compensation
If you are eligible and choose to participate, you will receive NKX019 and health assessments from a team with expertise in caring for people living with autoimmune disease. Costs for travel, lodging, childcare, and meals will be covered when you and your care partner go to the study clinic. Compensation for study participants and your care partner may also be available.
The Ntrust-2 study
The Ntrust-2 study is part of a broad effort of the global research community to develop more treatment options for people living with rheumatoid arthritis.
What is NKX019?
NKX019 is an investigational cell therapy being studied for rheumatoid arthritis (RA). It is designed to target and remove the cells that may trigger harmful antibodies, which attack the body’s own tissues in these conditions.
Who can join this study?
You may be eligible to participate in this study if you:
- Are 18 to 75 years old
- Have been diagnosed with rheumatoid arthritis (RA)
- Have received prior autoimmune disease treatments that may have not worked well for you
Compensation
If you are eligible and choose to participate, you will receive NKX019 and health assessments from a team with expertise in caring for people living with autoimmune disease. Costs for travel, lodging, childcare, and meals will be covered when you and your care partner go to the study clinic. Compensation for study participants and your care partner may also be available.
Conditions:
Rheumatoid
Rheumatoid Arthritis
Arthritis
Rheumatoid
Rheumatoid Arthritis (RA)
Featured Therapy
Unique Treatment for High Blood Pressure
Worried about high blood pressure? Think beyond typical high blood pressure treatments.
People who may be candidates for this procedure:
• Are at least 18 years old
• Have been unable to manage their high blood pressure with medications or lifestyle changes alone¹
Learn about a safe and effective procedure that may help reduce high blood pressure. See if you qualify today.
¹ Kandzari DE, et al. J Am Coll Cardiol. Nov 7, 2023;82(19):1809-1823.
People who may be candidates for this procedure:
• Are at least 18 years old
• Have been unable to manage their high blood pressure with medications or lifestyle changes alone¹
Learn about a safe and effective procedure that may help reduce high blood pressure. See if you qualify today.
¹ Kandzari DE, et al. J Am Coll Cardiol. Nov 7, 2023;82(19):1809-1823.
Conditions:
High Blood Pressure
High Blood Pressure (& [Essential Hypertension])
High Blood Pressure (Hypertension).
Hypertension
Essential Hypertension
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Conditions:
Healthy
Healthy Volunteer Study
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There's a big difference between the price on a landing page and what you actually pay. We went all the way through checkout so you know exactly what to expect.
📋 5 providers ranked by true monthly cost
💵 Options starting as low as $149/month
🏥 Only licensed providers using FDA-registered pharmacies
⭐ Real Trustpilot scores included — including the ones with mixed reviews
🔒 Includes cancellation policy warnings so you don't get stuck
Conditions:
Weight Loss
Morbid Obesity
Featured Trial
Healthy Participants Needed (Colonoscopy + Cancer Screening)
Recruiting
Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.
Conditions:
Healthy
Healthy Volunteers
Healthy Subjects
Healthy Volunteer
Healthy Participants
Featured Therapy
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Risks may include surgical, device, and stimulation-related complications. See important safety info: https://83b.co/tlcbld
Take our quick survey to see if this system could work for you.
Risks may include surgical, device, and stimulation-related complications. See important safety info: https://83b.co/tlcbld
Conditions:
Overactive Bladder
Urinary Incontinence
Idiopathic Overactive Bladder
Incontinence
Healthy
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Recruiting
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Boston Clinical Trials, Boston, Massachusetts
Conditions: Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis
Recruiting
The purpose of this study is to evaluate the pharmacokinetics (PK), efficacy, safety and immunogenicity of ustekinumab and guselkumab in active juvenile psoriatic arthritis (jPsA).
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
08/15/2025
Locations: Harvard Medical School - Boston Children's Hospital, Boston, Massachusetts
Conditions: Arthritis, Juvenile
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Recruiting
The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory autoimmune diseases (Breakfree-1).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2025
Locations: Local Institution - 0038, Boston, Massachusetts +1 locations
Conditions: Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, Rheumatoid Arthritis
A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic
Recruiting
To assess the emergence, type, severity, and potential causality of delayed adverse events following administration of a gene-modified Treg therapeutic.
Gender:
ALL
Ages:
Between 18 years and 71 years
Trial Updated:
08/07/2025
Locations: Tufts University, Boston, Massachusetts +2 locations
Conditions: Rheumatoid Arthritis (RA), Hidradenitis Suppurativa (HS)
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
Recruiting
This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts +1 locations
Conditions: Autoimmune Disease, Crohn Disease, Dermatomyositis, Inflammatory Bowel Disease, Multiple Sclerosis, Rheumatoid Arthritis, Sjogren Syndrome, Systemic Lupus Erythematosus, Systemic Scleroderma, Ulcerative Colitis, Hematopoietic and Lymphoid Cell Neoplasm, Psoriasis, Psoriatic Arthritis, Malignant Solid Neoplasm
The Osteoarthritis Prevention Study
Recruiting
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determi... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
07/18/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Osteoarthritis, Knee
RA-PRO PRAGMATIC TRIAL
Recruiting
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Tufts University, Boston, Massachusetts
Conditions: Rheumatoid Arthritis
Remote Tai Chi for Knee Osteoarthritis
Recruiting
The goal of this pragmatic randomized trial is to evaluate the effectiveness of remote Tai Chi to treat knee pain in adults with knee osteoarthritis. The main questions the trial aims to answer are:
* Compared to routine care, will patients with Knee OA receiving remote Tai Chi exhibit greater improvement in knee-related pain (WOMAC pain score, primary outcome), pain interference (PROMIS-Pain Interference, secondary outcome), and health-related quality of life at 3 months?
* Does remote tai chi... Read More
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
07/02/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Knee Osteoarthritis
The Role of Vitamin K on Knee Osteoarthritis Outcomes
Recruiting
The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most commonly used forms and doses include phylloquinone (vitamin K1; 1000µg or 500µg daily) or menaquinone-7 (MK-7 or vitamin K2; 300µg daily). However, whether these doses are adequate to increase vitamin K to levels that ameliorate risk of adverse OA outcomes is not known... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
06/03/2025
Locations: Boston Medical Center, Rheumatology Clinic, Boston, Massachusetts
Conditions: Osteo Arthritis Knee
INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE
Recruiting
The goal of this clinical trial is to evaluate the effectiveness of Neural Ice for pain management associated with knee osteoarthritis in adults aged 22-80 years. Participants will attend study visits and complete subject diaries. Participants will be followed for 6 months after study procedure.
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
05/21/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Osteoarthritis (OA) of the Knee
ZILRETTA in Subjects With Shoulder Osteoarthritis
Recruiting
Primary Objective: To assess the efficacy of ZILRETTA on pain following an intra-articular (IA) injection in subjects with glenohumeral osteoarthritis (OA) relative to normal saline placebo
Secondary Objective:
* To assess the efficacy of ZILRETTA on pain following an IA injection in subjects with glenohumeral OA relative to triamcinolone acetonide injectable suspension, immediate release (TCA-IR) and normal saline placebo
* To assess the safety of ZILRETTA in subjects with glenohumeral OA rel... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
05/19/2025
Locations: New England Baptist Hospital, Boston, Massachusetts
Conditions: Glenohumeral Osteoarthritis
Positive Minds Strong Joints for Knee Osteoarthritis
Recruiting
The aim of this research study is to test the feasibility of a physical and mental health intervention (Positive Minds, Strong Joints or PMSJ) for Black adults with knee osteoarthritis (OA).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/13/2025
Locations: Boston University, Boston, Massachusetts
Conditions: Osteoarthritis, Knee
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