The state of Massachusetts currently has 37 active clinical trials seeking participants for Healthy research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
Recruiting
We are doing this research to learn how healthy younger and older adults use two forms of vitamin B3-called nicotinamide mononucleotide (NMN) and nicotinamide (NAM)-to make NAD+. NAD+ is a natural substance that cells need for energy and other important processes. Our goal is to find out how these NAD precursors are absorbed and metabolized and how they raise NAD+ in different tissues. Who can join? Healthy adults men and women aged 18 to 40 (younger group) or 65 and older (older group) Partici... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Healthy Adults
TMS for Cognitive Decline in Aging and Preclinical AD
Recruiting
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measur... Read More
Gender:
ALL
Ages:
Between 40 years and 99 years
Trial Updated:
05/01/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations
Recruiting
Background: During the first few decades of life, the brain changes dramatically in shape and function. Sleep lets researchers measure these changes. Researchers want to create a database of sleep and neurodevelopmental data in a group of infants and children to learn more. Objective: To address a knowledge and data gap in the field of sleep and neurodevelopment in infants and children. Eligibility: Children ages 6 months to 76 months who may or may not be at risk for neurodevelopmental and... Read More
Gender:
ALL
Ages:
Between 6 months and 8 years
Trial Updated:
04/29/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Healthy Children, Children With Neurodevelopmental Disorders, Children With Neuropsychiatric Disorders, Children With Behavioral Syndromes
Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2
Recruiting
This is a cluster randomized controlled trial of 30 food pantries affiliated with the Greater Boston Food Bank to test the use of behavioral economics (BE) tools to encourage food pantries to implement the Supporting Wellness at Pantries (SWAP) program, with the goal of fostering accurate use of SWAP traffic light labels on pantry shelves and increasing the healthfulness of foods chosen by pantry clients. Primary outcomes will be assessed at 6 and 12 months to compare the implementation and effe... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Food Insecurity, Implementation Science, Diet, Healthy, Behavioral Economics
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation
Recruiting
The goal of this clinical study is to evaluate safety of Xenon gas inhalation in healthy volunteers. This first phase safety clinical study is part of evaluation of the xenon gas inhalation as a therapy for neurodegenerative diseases, such as Alzheimer's disease. The investigators will administer xenon gas in low concentration to people via anesthetic machine, observe participants for sedation and any unexpected side effects, collect blood at each visit and measure the vital signs. There are fo... Read More
Gender:
ALL
Ages:
Between 55 years and 75 years
Trial Updated:
04/18/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Healthy Volunteer Study
Study to Evaluate the Effects of NMRA-323511 Among Healthy Elderly and Adults With Agitation Associated With Dementia Due to Alzheimer's Disease
Recruiting
This study consists of 2 parts, Part A and Part B. Part A is a single center, randomized, double-blind, placebo-controlled cohort designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of NMRA-323511 among healthy elderly. Part B is a multicenter, randomized, double-blinded, placebo-controlled, parallel-group cohort to evaluate the safety, tolerability, and efficacy of NMRA-323511 among adults with Agitation Associated with Dementia due to Alzheimer's Disease. Part A consists... Read More
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
04/16/2025
Locations: Neumora Investigator Site, Belmont, Massachusetts
Conditions: Alzheimer's Disease, Healthy Elderly
Causal Role of Brain Networks in Episodic Memory
Recruiting
The goal of this study is to understand the basic brain mechanisms supporting episodic memory in healthy young adults. Transcranial magnetic stimulation will be used to influence brain activity in regions thought to be important for episodic memory. Behavioral testing and MRI will be used to measure the effects of stimulation on memory and on changes in brain network interactions, allowing us to draw causal inferences regarding the role of specific brain regions in memory processes.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
04/14/2025
Locations: Boston College, Chestnut Hill, Massachusetts
Conditions: Episodic Memory, Healthy
Mixed Vs Blocked Search: Four Unique Tasks
Recruiting
The goal is to look for qualitative differences in visual search behavior when one search is performed many times in a row compared to when multiple search tasks are intermixed. Four search tasks are tested. In the Mixed condition, the four tasks are randomly changed from trial to trial. In the Blocked condition, each task is run as a block of 100 trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Vision, Healthy, Attention
Experiment 2: One Target in Many Situations
Recruiting
The goal is to look for qualitative differences in visual search behavior when one search is performed many times in a row compared to when multiple search tasks are intermixed. Four search tasks are tested. The target is the same in every task but the types of distractors change from task to task. In the Mixed condition, the four tasks are randomly changed from trial to trial. In the Blocked condition, each task is run as a block of 100 trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Brigham & Women's Hospital, Newton, Massachusetts
Conditions: Vision, Healthy, Attention
Experiment 3: Mixed vs Blocked; Dashboard Paradigm
Recruiting
The goal is to look for qualitative differences in visual search behavior when one search is performed many times in a row compared to when multiple search tasks are intermixed. Four search tasks are tested. The target is the same in every task but the types of distractors change from task to task. In this version, observers get some degree of choice in what they are searching.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Vision, Healthy, Attention
Personalized Responses to Dietary Composition Trial 3
Recruiting
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and controlled dietary intervention, for the purpose of testing postprandial responses to specific mixed meals, in addition to a free-living period with a dietary record for measuring responses to a large v... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Zoe US Inc., Needham, Massachusetts
Conditions: Diabetes, Heart Diseases, Diet Habit, Diet Modification, Healthy, Obesity, Metabolism, Microbial Colonization
A Study on the Safety and Immunogenicity of Hexavalent Influenza mRNA Vaccine in Adult Participants 50 Years of Age and Older
Recruiting
The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular injection of different formulations of a hexavalent influenza messenger ribonucleic acid (mRNA) vaccine composed of differing dose levels of trivalent (TIV) mRNA hemagglutinin (HA) in combination with TIV mRNA-neuraminidase (NA) compared to an active control ((Fluzone standard-dose quadrivalent influenza vaccine (QIV-SD) or Fluzone high-dose quadrivalent influenza vaccine (QIV-HD) in adults 50 years... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/02/2025
Locations: Boston Clinical Trials- Site Number : 8400009, Boston, Massachusetts +1 locations
Conditions: Influenza, Healthy Volunteers