The city of Boston, Massachusetts, currently has 26 active clinical trials seeking participants for Healthy research studies.
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Recruiting
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, pH and food effect, and preliminary efficacy of BMS-986470 in healthy volunteers and participants with sickle cell disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Local Institution - 0024, Boston, Massachusetts +1 locations
Conditions: Anemia, Sickle Cell, Healthy Volunteers
Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations
Recruiting
Background: During the first few decades of life, the brain changes dramatically in shape and function. Sleep lets researchers measure these changes. Researchers want to create a database of sleep and neurodevelopmental data in a group of infants and children to learn more. Objective: To address a knowledge and data gap in the field of sleep and neurodevelopment in infants and children. Eligibility: Children ages 6 months to 76 months who may or may not be at risk for neurodevelopmental and... Read More
Gender:
ALL
Ages:
Between 6 months and 8 years
Trial Updated:
06/24/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Healthy Children, Children With Neurodevelopmental Disorders, Children With Neuropsychiatric Disorders, Children With Behavioral Syndromes
TMS for Cognitive Decline in Aging and Preclinical AD
Recruiting
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measur... Read More
Gender:
ALL
Ages:
Between 40 years and 99 years
Trial Updated:
06/16/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
Telehealth for Pain and Unhealthy Drinking Among PLWH
Recruiting
This randomized controlled trial is a between-groups design to compare the Motivational and Cognitive Behavioral Management for Alcohol and Pain (MCBMAP) Intervention to a Brief Advice and Information Control condition. Two-hundred and fifty participants who have HIV with moderate or greater chronic pain will be randomized for the trial. Recruitment will take place through digital media. A unique feature of this intervention trial is that most of the procedures will be conducted remotely which... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2025
Locations: Charles River Campus, Boston University, Psychology Department- remote study, Boston, Massachusetts
Conditions: HIV, Chronic Pain, Unhealthy Alcohol Use
Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
Recruiting
The goal of this research is to learn how a new device called the wireless thermal capsule (WTC) can collect thermal data to help see diseases that happen in the gastrointestinal (GI) tract, such as Crohn's Disease.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/13/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Crohn Disease, Inflammatory Bowel Diseases, Healthy
REcovery From DEXmedetomidine-induced Unconsciousness
Recruiting
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can be used to measure brain complexity during dexmedetomidine sedation without arousing study participants.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/13/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anesthesia, Healthy, Consciousness, Level Altered
Kidney Blood Flow During Exercise in Older African American Adults
Recruiting
The goal of this preliminary study is to learn if healthy older African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are: * Do healthy older AA adults have a larger decrease in kidney blood flow during exercise compared to W adults? * Do healthy older AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults? During one visit in t... Read More
Gender:
ALL
Ages:
Between 55 years and 79 years
Trial Updated:
06/11/2025
Locations: University of Massachusetts Boston, Boston, Massachusetts
Conditions: Healthy
Neural Control of Kidney Blood Flow During Exercise in African American Adults
Recruiting
The goal of this clinical trials is to learn if healthy young African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are: * Do healthy young AA adults have a larger decrease in kidney blood flow during exercise compared to W adults? * Do healthy young AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults? During two visits in th... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
06/04/2025
Locations: University of Massachusetts Boston, Boston, Massachusetts
Conditions: Healthy
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Recruiting
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Health Test could serve as a predictive biomarker of neurodegenerative disorders. This understanding will aid in the development of a noninvasive, cost-effective diagnostic tool that reliably and specifica... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
Recruiting
We are doing this research to learn how healthy younger and older adults use two forms of vitamin B3-called nicotinamide mononucleotide (NMN) and nicotinamide (NAM)-to make NAD+. NAD+ is a natural substance that cells need for energy and other important processes. Our goal is to find out how these NAD precursors are absorbed and metabolized and how they raise NAD+ in different tissues. Who can join? Healthy adults men and women aged 18 to 40 (younger group) or 65 and older (older group) Partici... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Healthy Adults
Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2
Recruiting
This is a cluster randomized controlled trial of 30 food pantries affiliated with the Greater Boston Food Bank to test the use of behavioral economics (BE) tools to encourage food pantries to implement the Supporting Wellness at Pantries (SWAP) program, with the goal of fostering accurate use of SWAP traffic light labels on pantry shelves and increasing the healthfulness of foods chosen by pantry clients. Primary outcomes will be assessed at 6 and 12 months to compare the implementation and effe... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/27/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Food Insecurity, Implementation Science, Diet, Healthy, Behavioral Economics
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation
Recruiting
The goal of this clinical study is to evaluate safety of Xenon gas inhalation in healthy volunteers. This first phase safety clinical study is part of evaluation of the xenon gas inhalation as a therapy for neurodegenerative diseases, such as Alzheimer's disease. The investigators will administer xenon gas in low concentration to people via anesthetic machine, observe participants for sedation and any unexpected side effects, collect blood at each visit and measure the vital signs. There are fo... Read More
Gender:
ALL
Ages:
Between 55 years and 75 years
Trial Updated:
04/18/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Healthy Volunteer Study