Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
11/22/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
NeuroGlove Anxiety and Depression Study
Recruiting
This is a prospective, homebased, interventional clinical study containing 10 subjects who will be enrolled. Approximately 10 (10) subjects with active anxiety and depression symptoms will receive treatment using the NeuroGlove.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/03/2023
Locations: NeuroGlove, Minneapolis, Minnesota
Conditions: Anxiety, Depression, Anxiety Depression, Depression, Anxiety
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Rates of Depression
Recruiting
Depression is a common psychological disorder seen in 18.5% of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans. Improving the rate of depression recovery and remission is vital to enhance OEF/OIF/OND Veteran's ability to improve work and home adjustment and overall quality of life. OEF/OIF/OND Veterans have reported many barriers to following through with Cognitive therapy skills practice assignments, a key component of CBT therapy, the lead... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
09/13/2023
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: Depression
Enhanced Spatial Targeting in ECT Utilizing FEAST
Recruiting
The purpose of this research study is to find an alternative version of ECT that reduces the negative side effects (mainly memory loss) while still providing patients with relief from depressive symptoms. Previous forms of ECT may use Bilateral (electrodes on both sides of the head) or Right Unilateral (RUL) (electrodes on one side of the head). Our research focuses on adjusting the placement of electrodes on one side of the head in order to better stimulate the Prefrontal Cortex (PFC) of the br... Read More
Gender:
All
Ages:
Between 22 years and 90 years
Trial Updated:
09/08/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
PCS in Severe Treatment Resistant Depression
Recruiting
This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms. Participants receive intermittent electrical stimulation to the brain, which involves surgically placing electric leads in between the tough fibrous membrane covering the surface of the brain and the surface of the brain itself. This type of stimulation is referred to as bilateral subdural prefrontal cortical stimulation (PCS) because it will sp... Read More
Gender:
All
Ages:
Between 22 years and 55 years
Trial Updated:
09/08/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Treatment Resistant Depression
EPI-MINN: Targeting Cognition and Motivation - National
Recruiting
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using a 12-week mobile intervention program. Participants who are receiving care at coordinated specialty care (CSC) early psychosis clinics across the United States will be recruited to participate in this study. A qualifying CSC program will provide comprehensive clinical se... Read More
Gender:
All
Ages:
Between 15 years and 40 years
Trial Updated:
06/22/2023
Locations: University of Minnesota Department of Psychiatry & Behavioral Sciences, Minneapolis, Minnesota
Conditions: Psychosis, Psychosis Nos/Other, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder, Prodromal Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Schizophreniform Disorders, Major Depression With Psychotic Features, Unspecified Psychosis, Bipolar Disorder
Cognitive and Affective Processes Online
Recruiting
This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and discriminant validity of cognitive and affective constructs such as those introduced to understand mental disorders, and (4) sensitivity (and correspondence) to individual differences. For these tests to be useful in studying clinical conditions, they must show adequate relia... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/15/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Depression
Transdiagnostic Cognitive Biomarkers
Recruiting
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depres... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pain, Depression
Positive Suggestions Via MP3 Messages
Recruiting
The purpose of this study is to assess the use of an audio recording containing positive suggestion as a means to provide needed psychological support to critically ill patients in a feasible and reliable manner.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Post Intensive Care Unit Syndrome, Psychological Trauma, Anxiety, Depression, PTSD
8 Week Multi-site Study of MYDAYIS® for Bipolar Depression
Recruiting
This protocol is a Phase 2 multi-site study which aims to evaluate the safety and effectiveness of MYDAYIS® as adjunctive therapy for adults with bipolar depression. Results from this study WILL NOT be used to contribute to an approval of MYDAYIS ® for this indication.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
02/10/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Bipolar Depression
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)
Recruiting
The objective of this study is to collect data to finalize the development of MEB-001 softward as a medical device. The data collected in this study will be used to develop MEB-001 machine learning algorithms by training the algorithms to match the patient's demographic and clinical information, and the objective physiological signals (i.e., electroencephalogram (EEG) and electrocardiogram (ECG)) recorded during PSG with the diagnosis of cMDE performed through the MINI neuropsychiatric evaluatio... Read More
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
01/23/2023
Locations: Lakeland Sleep Store, Blaine, Minnesota
Conditions: Depressive Episode, Depression, Depressive Disorder, Depressive Disorder, Major, Depression Mild