All Clinical Trials

A listing of 23118 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

Home

All Trials

Show Filters

Match to Clinical Trials

Access to cutting-edge treatments

Latest clinical trials

Find trials in your area

Start Matching

Filter by Age

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Offer

Lose Weight with GLP-1 Medications

Recruiting

Policy Lab has partnered with CareGLP to offer trusted access to GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.

GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.

As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.

Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

Learn More

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

NCT01174108

Recruiting

Background: * Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell transplants can have serious complications, researchers are interested in developing new approaches to stem cell transplants that will reduce the likelihood of these complications. * By reducing the number of white blood cells included in the blood taken during the stem cell collection process, and replacing them with a smaller amount of white blood cells collected prior to stem cell donation, the stem cell transplant may be less likely to cause severe complications for the recipient. Researchers are investigating whether altering the stem cell transplant donation procedure in this manner will improve the likelihood of a successful stem cell transplant with fewer complications. Objectives: - To evaluate a new method of stem cell transplantation that may reduce the possibly of severe side effects or transplant rejection in the recipient. Eligibility: * Recipient: Individuals between 4 and 80 years of age who have been diagnosed with a blood disease that can be treated with allogenic stem cell transplants. * Donor: Individuals between 4 and 80 years of age who are related to the recipient and are eligible to donate blood. OR unrelated donors found through the National Marrow Donor Program. Design: * All participants will be screened with a physical examination and medical history. * DONORS: * Donors will undergo an initial apheresis procedure to donate white blood cells. * After the initial donation, donors will receive injections of filgrastim to release bone marrow cells into the blood. * After 5 days of filgrastim injections, donors will have apheresis again to donate stem cells that are present in the blood. * RECIPIENTS: * Recipients will provide an initial donation of white blood cells to be used for research purposes only. * From 7 days before the stem cell transplant, participants will be admitted to the inpatient unit of the National Institutes of Health Clinical Center and will receive regular doses of cyclophosphamide, fludarabine, and anti-thymocyte globulin to suppress their immune system and prepare for the transplant. * After the initial chemotherapy, participants will receive the donated white blood cells and stem cells as a single infusion. * After the stem cell and white blood cell transplant, participants will have regular doses of cyclosporine and methotrexate to prevent rejection of the donor cells. Participants will have three doses of methotrexate within the week after the transplant, but will continue to take cyclosporine for up to 4 months after the transplant. * Participants will remain in inpatient care for up to 1 month after the transplant, and will be followed with regular visits for up to 3 years with periodic visits thereafter to evaluate the success of the transplant and any side effects. Read Less

Gender:

ALL

Ages:

Between 4 years and 80 years

Trial Updated:

06/18/2025

Locations: University of Maryland, Baltimore (UMB), Baltimore, Maryland +1 locations

Conditions: Severe Aplastic Anemia, MDS (Myelodysplastic Syndrome)

Learn More ›

Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer

NCT04464226

Recruiting

The aim of this study is to provide darolutamide treatment to patients who participated in a previous study with darolutamide supported by Bayer and the treating doctor considers that the continuation of the treatment with darolutamide to be beneficial. Patients will be carried over from the previous studies and continue in this study with darolutamide treatment on the same dosage. They will also return to the study centers for doctor's visits as often as they did in the previous study.

Gender:

MALE

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: Urology Centers of Alabama, PC, Homewood, Alabama +380 locations

Urology Centers of Alabama, PC, Homewood, Alabama

Ironwood Cancer and Research Centers - Chandler I, Chandler, Arizona

City of Hope National Medical Center, Duarte, California

Tower Urology, Inc, Los Angeles, California

VA Greater Los Angeles Healthcare System, Los Angeles, California

Stanford Cancer Center Palo Alto, Palo Alto, California

San Diego Clinical Trials, San Diego, California

TOI Clinical Research, Whittier, California

VA Eastern Colorado Health Care System, Aurora, Colorado

The Urology Center Of Colorado, Denver, Colorado

Boca Raton Regional Hospital - Oncology, Boca Raton, Florida

Advent Health Medical Group Urology, Orlando, Florida

Jesse Brown VA Medical Center - Cardiology, Chicago, Illinois

Illinois CancerCare - Peoria, Peoria, Illinois

First Urology PSC, Jeffersonville, Indiana

Norton Cancer Institute - Downtown, Louisville, Kentucky

Anne Arundel Health System, Annapolis, Maryland

Chesapeake Urology Associates - Towson, Baltimore, Maryland

Johns Hopkins Hospital - Pulmonology, Baltimore, Maryland

TidalHealth Peninsula Regional, Inc., Salisbury, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Henry Ford Hospital - OB/GYN, Detroit, Michigan

St. Vincent Regional Hospital - Oncology, Billings, Montana

Urology Cancer Center, PC, Omaha, Nebraska

XCancer Omaha, Omaha, Nebraska

New Jersey Urology - Voorhees, Voorhees, New Jersey

New Mexico Cancer Center - Albuquerque, Albuquerque, New Mexico

New York Cancer & Blood Specialists - Eastchester, Bronx, New York

Montefiore Einstein Center for Cancer Care, Bronx, New York

University of Rochester Medical Center, Rochester, New York

Associated Medical Professionals of NY, PLLC, Syracuse, New York

Gabrail Cancer Center, Canton, Ohio

The Urology Group, Cincinnati, Ohio

The Ohio State University - Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, Ohio

MidLantic Urology - Bala Cynwyd, Bala-Cynwyd, Pennsylvania

Andrews & Patel Associates, Camp Hill, Pennsylvania

Charleston Oncology - Downtown, Charleston, South Carolina

Bon Secours St. Francis Hospital, Greenville, South Carolina

Carolina Urological Research Center, Myrtle Beach, South Carolina

Urology Associates, PC, Nashville, Tennessee

Urology Clinics of North Texas, Dallas, Texas

Huntsman Cancer Institute- Salt Lake City, Salt Lake City, Utah

Inova Schar Cancer Insitute - Inova Fairfax Hospital, Fairfax, Virginia

Virginia Commonwealth University, Richmond, Virginia

Providence Regional Cancer Partnership, Everett, Washington

Centro de Urología, Buenos Aires, Ciudad Auton. De Buenos Aires

Adelaide Cancer Centre Research Pty Ltd, Kurralta Park, South Australia

Universitätsklinikum AKH Wien, Wien, Not set

N.N. Alexandrov National Cancer Centre of Belarus - Oncology Department, Lesnoy, Not set

Minsk City Clinical Oncological Dispensary - Oncology Department, Minsk, Not set

GZA Ziekenhuizen, Wilrijk, Antwerpen

CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set

UZ Gent, Gent, Not set

AZ Groeninge Campus Kennedylaan, Kortrijk, Not set

CHU de Liège, Liege, Not set

CHU UCL Namur, Namur, Not set

Hospital São Rafael, Salvador, Bahia

Santa Casa de Misericórdia da Bahia, Salvador, Bahia

Instituto do Cancer do Ceará, Fortaleza, Ceará

Hospital Evangélico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim, Espírito Santo

Hosp. Araujo Jorge da Associação de Combate ao Câncer, Goiânia, Goiás

COT Centro Oncologico do Triangulo Ltda, Uberlandia, Minas Gerais

Liga Paranaense de Combate ao Cancer-Hosp Erasto Gaertner, Curitiba, Parana

Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica, Natal, Rio Grande Do Norte

Associação Hospitalar Beneficente São Vicente de Paulo, Passo Fundo, Rio Grande Do Sul

Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology, Porto Alegre, Rio Grande Do Sul

União Bras. de Edu. e Assist. Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande Do Sul

Clínica de Neoplasias Litoral Ltda, Itajaí, Santa Catarina

Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos/SP, Sao Paulo

Hospital Amaral Carvalho, Jaú, Sao Paulo

Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirao Preto, Sao Paulo

IEP São Lucas, São Paulo, Sao Paulo

Instituto do Cancer do Estado de Sao Paulo, São Paulo, Sao Paulo

IBCC - Instituto Brasileiro de Controle do Cancer, São Paulo, Sao Paulo

Inst. de Assistência Médica ao Sérvidor Público Estadual, São Paulo, Sao Paulo

Medical Center Kalimat, Sofia, Not set

Complex Oncology Center - Vratsa, Vratsa, Not set

Prostate Cancer Centre, Calgary, Alberta

Cross Cancer Institute, Edmonton, Alberta

Nova Scotia Health Authority, Halifax, Nova Scotia

G. Kenneth Jansz Medicine Professional Corporation, Burlington, Ontario

Kingston Health Sciences Centre, Kingston, Ontario

London Health Sciences Centre, London, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

Princess Margaret Hospital-University Health Network, Toronto, Ontario

CIUSSS de l'Estrie- Centre Haute-Yamaska, Granby, Quebec

Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopi, Montreal, Quebec

Anhui Provincial Hospital, Hefei City, Anhui Province, Anhui

The Second Hospital of Anhui medical university, Hefei, Anhui

Beijing Cancer Hospital, Beijing, Beijing

Beijing Hospital, Beijing, Beijing

The First Affiliated hospital of Fujian Medical University, Fuzhou, Fujian

The First Affiliated Hospital of Xiamen University, Xiamen, Fujian

2nd Affiliated Hosp. of Shantou University Medical College, Shantou, Guangdong

Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech., Wuhan, Hubei

Hubei Cancer Hospital, Wuhan, Hubei

Hunan Cancer Hospital, Changsha, Hunan

Jiangsu Cancer Hospital, Nanjing, Jiangsu

NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School, Nanjing, Jiangsu

The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu

Nantong tumor hospital, Nantong, Jiangsu

The 2nd Affiliated Hospital of Soochow University, Suzhou, Jiangsu

The First Affiliated Hospital of NanChang University, Nanchang, Jiangxi

The First Hospital of Jilin University, Changchun City, Jilin

Liaoning Cancer Hospital and Institute, Shengyang, Liaoning

Shengjing Hospital of China Medical University, Shenyang, Liaoning

Qilu Hosp., Shandong Univ., Jinan, Shandong

Yantai Yuhuangding Hospital, Yantai, Shandong

Shanxi Medical University - First Hospital, Taiyuan, Shanxi

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi

University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital), Chengdu, Sichuan

Sichuan University West China Hospital, Chengdu, Sichuan

ZheJiang Provincial People's Hospital, Hangzhou, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, Not set

Peking University Third Hospital, Beijing, Not set

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (SAMSPH), Chengdu, Not set

Chongqing Cancer Hospital, Chongqing, Not set

Sun Yat-sen University Cancer Center, Guangzhou, Not set

Ningbo First Hospital, Ningbo, Not set

The Affiliated Hospital of Qingdao University, Shandong, Not set

Fudan University Shanghai Cancer Center, Shanghai, Not set

Ruijin Hosp. Shanghai Jiaotong Univ.School of Medicine, Shanghai, Not set

Zhongshan Hospital, Fudan University, Shanghai, Not set

Huadong Hospital, Affiliated to Fudan University, Shanghai, Not set

Shanghai Tenth People's Hospital, Shanghai, Not set

Shanghai General Hospital, Shanghai, Not set

Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, Not set

Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set

The Second Hospital of Tianjin Medical University, Tianjin, Not set

ZheJiang Provincial People's Hospital, Zhejiang, Not set

Hospital Pablo Tobón Uribe, Medellin, Antioquia

Oncomédica S.A., Montería, Córdoba

Fundación Oftalmológica de Santander Carlos Ardila Lule, Florida Blanca, Santander

Masarykuv onkologicky ustav, Brno, Not set

Nemocnice Jablonec nad Nisou, Jablonec nad Nisou, Not set

Fakultni nemocnice Kralovske Vinohrady, Praha 10, Not set

Urocentrum Praha, s.r.o., Praha 2, Not set

Všeobecná fakultní nemocnice v Praze, Praha 2, Not set

ANDROGEOS, spol. s r.o., Praha 6, Not set

Sihtasutus Põhja-Eesti Regionaalhaigla - Onkoloogia- ja hematoloogiakliinik, Tallinn, Not set

HUS, Meilahden sairaala, Helsinki, Uusimaa

Keski-Suomen sairaala Nova, Jyväskylä, Not set

Mikkelin keskussairaala, Mikkeli, Not set

Oulun yliopistollinen sairaala, Oulu, Not set

Seinäjoen keskussairaala, Seinäjoki, Not set

Tampereen yliopistollinen sairaala, Tampere, Not set

Turun yliopistollinen keskussairaala, Turku, Not set

Centre Hospitalier Universitaire - Angers, Angers, Not set

Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale, Bordeaux, Not set

Clinique Lanroze, Brest, Not set

Centre Jean Perrin, Clermont-ferrand, Not set

Centre d'Oncologie et de Radiologie du Parc, Dijon, Not set

Institut Paoli-Calmettes - Marseille, Marseille, Not set

ICM - Institut du Cancer de Montpellier - Val d'Aurelle, Montpellier Cedex, Not set

Centre d'Oncologie de Gentilly, Nancy, Not set

Hopital Hotel Dieu - Nantes, Nantes, Not set

Hôpital Saint Louis, Paris, Not set

HCL - Centre Hospitalier Lyon Sud, Pierre Benite, Not set

Hôpital de la Milétrie, Poitiers, Not set

Institut de Cancerologie Jean Godinot - Departement oncologie medicale, Reims, Not set

CHU Rennes - Hopital Pontchaillou, Rennes Cedex, Not set

Hôpital Charles Nicolle, Rouen, Not set

Hôpital d'Instruction des Armées Begin, Saint Mande, Not set

Institut de Cancerologie Ouest - Saint-Herblain, Saint-Herblain, Not set

Centre Médico-Chirurgical Foch, Suresnes, Not set

Hopital Bretonneau, Tours, Not set

Gustave Roussy - Departement Oncologie-Radiotherapie, Villejuif Cedex, Not set

Urologische Gemeinschaftspraxis Carl-Andreas-Meilinger, Emmendingen, Baden-Württemberg

Universitätsklinikum Freiburg, Freiburg, Baden-Württemberg

Urologische GemPraxis Dr. R. Rudolph, Kirchheim unter Teck, Baden-Württemberg

Urologische Gemeinschaftspraxis Muehlacker, Muehlacker, Baden-Württemberg

Studienpraxis Urologie, Nürtingen, Baden-Württemberg

Urologische Gemeinschaftspraxis Dr. Simone Maier, Reutlingen, Baden-Württemberg

Uniklinik Tübingen / Urologie, Tübingen, Baden-Württemberg

Universitätsklinikum Ulm, Ulm, Baden-Württemberg

Universitätsklinikum Erlangen, Erlangen, Bayern

Universitätsklinikum der Johann Wolfgang Goethe Universität, Frankfurt, Hessen

Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Niedersachsen

Gesundheitszentrum Holzminden, Holzminden, Niedersachsen

Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Nordrhein-Westfalen

Praxis Drs. Tim Schneider /B. Schneider, Mühlheim, Nordrhein-Westfalen

Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen

Uro-Gyn-Zentrum Wall Hr. Dr. Jochen Gleißner, Wuppertal, Nordrhein-Westfalen

Universitätsmedizin der Johannes Gutenberg Universität Mainz, Mainz, Rheinland-Pfalz

Medizinische Fakultät der Otto-von-Guericke Universität, Magdeburg, Sachsen-Anhalt

Friedrich-Schiller-Uni. Jena, Jena, Thuringen

Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set

Tolna Varmegyei Balassa Janos Korhaz, Szekszard, Not set

Zala Varmegyei Szent Rafael Korhaz, Zalaegerszeg, Not set

Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set

Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department, Petach Tikva, Not set

Health Corporation of the Ziv Medical Center (R.A.), Zefat, Not set

IRCCS Istituto Nazionale Tumori Fondazione Pascale, Napoli, Campania

Azienda Ospedaliero Universitaria Parma, Parma, Emilia-Romagna

Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica, Orbassano, Piemonte

Istituto Di Candiolo Fondazione Del Piemonte Per L'Oncologia IRCCS, Torino, Piemonte

Istituto Oncologico Veneto_Padova - UOC Oncologia 1, Padova, Veneto

Nagoya University Hospital, Nagoya, Aichi

Asahi General Hospital, Asahi, Chiba

Toho University Sakura Medical Center, Sakura, Chiba

Gunma University Hospital, Maebashi, Gunma

Sapporo Medical University Hospital, Sapporo, Hokkaido

Kobe University Hospital, Kobe, Hyogo

National hospital Organization Mito Medical Center, Higashiibaraki, Ibaraki

Kitasato University Hospital, Sagamihara, Kanagawa

Yokohama City University Medical Center, Yokohama, Kanagawa

Yokosuka Kyosai Hospital, Yokosuka, Kanagawa

Mie University Hospital, Tsu, Mie

National Hospital Organization Shinshu Ueda Medical Center, Ueda, Nagano

Oita University Hospital, Yufu, Oita

Osaka International Cancer Institute, Osaka-shi, Osaka

Kindai University Hospital, Sayama, Osaka

The University of Osaka Hospital, Suita, Osaka

Hamamatsu University Hospital, Hamamatsu, Shizuoka

Saiseikai Utsunomiya Hospital, Utsunomiya, Tochigi

Nippon Medical School Hospital, Bunkyo-Ku, Tokyo

Juntendo University Hospital, Bunkyo-ku, Tokyo

Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo

Kyorin University Hospital, Mitaka, Tokyo

Tokyo Metropolitan Police Hospital, Nakano-ku, Tokyo

Keio University Hospital, Shinjuku-ku, Tokyo

The Fraternity Memorial Hospital, Sumida-ku, Tokyo

Tottori University Hospital, Yonago, Tottori

Yamaguchi University Hospital, Ube, Yamaguchi

Chiba Cancer Center, Chiba, Not set

Gifu Prefectural General Medical Center, Gifu, Not set

Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Not set

National Cancer Center Hospital East, Kashiwa, Not set

National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set

University of Miyazaki Hospital, Miyazaki, Not set

Nagasaki University Hospital, Nagasaki, Not set

Osaka Metropolitan University Hospital, Osaka, Not set

Osaka General Medical Center, Osaka, Not set

Toyama University Hospital, Toyama, Not set

Wakayama Medical University Hospital, Wakayama, Not set

Chungbuk National University Hospital, Cheongju-si, Chungcheongbugdo

Chonnam National University Hospital, Gwangju, Gwangju Gwang''yeogsi

Seoul National Univ. Bundang Hospital, Seongnam-si, Gyeonggido

Severance Hospital, Yonsei University Health System, Seoul, Seoul Teugbyeolsi

Asan Medical Center, Seoul, Seoul Teugbyeolsi

Seoul National University Hospital, Seoul, Seoul Teugbyeolsi

Gangnam Severance Hospital, Yonsei University Health System, Seoul, Seoul Teugbyeolsi

Inje University Busan Paik Hospital, Busan, Not set

Keimyung University Dongsan Medical Center, Daegu, Not set

Kyungpook National University Chilgok Hospital, Daegu, Not set

Gachon University Gil Medical Center, Incheon, Not set

Samsung Medical Center, Seoul, Not set

The Catholic University of Korea Seoul St. Mary's Hospital, Seoul, Not set

Daugavpils Regional Hospital, Daugavpils, Not set

Litavniece Dzintra practice in urology and oncological chem., Liepaja, Not set

P. Stradins Clinical University Hospital, Riga, Not set

AS "Association of Health Centers" polyclinic "Elite", Riga, Not set

Riga East Clinical University Hospital "Gailezers", Riga, Not set

Vidzemes Hospital, Valmiera, Not set

Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set

PI Klaipedos University Hospital, Klaipeda, Not set

National Cancer Institute, Vilnius, Not set

Vilnius University Hospital Santaros Klinikos, Vilnius, Not set

Hospital Universitario "José Eleuterio González", Monterrey, Nuevo Leon

INBIOMEDyC Querétaro, Santiago de Querétaro, Querétaro

Nederlands Kanker Instituut, Amsterdam, Not set

Academisch Medisch Centrum (AMC), Amsterdam, Not set

HagaZiekenhuis, Den Haag, Not set

Albert Schweitzer Ziekenhuis | Dordwijk - Cardiology Department, Dordrecht, Not set

Zuyderland Medical Centre | Internal Medicine Department, Geleen, Not set

Tergooi MC | Hilversum - Wetenschapsbureau, Hilversum, Not set

Spaarne Gasthuis, Hoofddorp, Not set

ETZ TweeSteden Ziekenhuis (vh Maria Ziekenhuis), Tilburg, Not set

Centro Médico Monte Carmelo - Oncology Department, La Victoria, Arequipa

Hospital Central de la Fuerza Aerea del Perú, Lima, Not set

Instituto Peruano de Oncología & Radioterapia - Oncologia SA - Oncology Department, Lima, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

ETG Network Spolka z o.o., Lodz, Not set

KO-MED Centra Kliniczne Lublin II, Lublin, Not set

Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina, Otwock, Not set

SPZOZ Wojewodzki Szpital Specjalistyczny nr 3, Rybnik, Not set

Urologica Praktyka Lekarska Adam Marcheluk, Siedlce, Not set

Mazowiecki Szpital Onkologiczny, Waliszew, Not set

Centrum Onkologii - Instytut im. M.Sklodowskiej-Curie, Warszawa, Not set

Szpital Grochowski im. dr.med. Rafala Masztaka, Warszawa, Not set

EMC Instytut Medyczny SA, Wroclaw, Not set

ULSM - Hospital Pedro Hispano, Matosinhos, Porto

Hospital Garcia de Orta | Research Department, Almada, Setúbal

IPO Lisboa, Lisboa, Not set

CHLC - Hospital Sao Jose, Lisboa, Not set

Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica, Lisboa, Not set

IPO Porto, Porto, Not set

Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos, Porto, Not set

Institutul Clinic Fundeni, Bucuresti, Not set

Sf. Nectarie Oncology Center, Craiova, Not set

Spitalul Clinic Judetean de Urgenta Oradea, Oradea, Not set

Spitalul Clinic Judetean Mures, Targu-Mures, Not set

Ltd "EVIMED", Chelyabinsk, Not set

Chelyabinsk Regional Oncology Dispensary, Chelyabinsk, Not set

Ivanovo Regional Oncology Dispensary, Ivanovo, Not set

Republican Clinical Oncology Dispensary Kazan, Kazan, Not set

Krasnoyarsk Regional Clinical Oncology Dispensary, Krasnoyarsk, Not set

Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS, Moscow, Not set

Moscow Scient. Res. Institute of Oncology n.a P.A. Hertzen, Moscow, Not set

City clinical hospital #40 Moscow, Moscow, Not set

City Outpatient Clinic #1 of Privolzhsky Regional Med. Cent., Nizhny Novgorod, Not set

LLC Reafan, Novosibirsk, Not set

Medical Center "Avicenna", Novosibirsk, Not set

National Medical Research Radiology Center, Obninsk, Not set

Clinical Oncological Dispensary of Omsk Region, Omsk, Not set

Rostov State Medical University, Rostov-on-Don, Not set

Saratov State Medical University, Saratov, Not set

Leningrad Regional Oncology Dispensary, St. Petersburg, Not set

St. Petersburg Clinical Hospital of RAS, St. Petersburg, Not set

St. Petersburg Medical University n.a. I.P. Pavlov, St. Petersburg, Not set

Multi-Field Clinical Medical Center "Medical City", Tyumen, Not set

Regional Clinical Oncology Dispensary, Vladimir, Not set

Clinical Hospital Center Bezanijska kosa, Belgrade, Not set

Clinical Center Nis, Nis, Not set

J. BREZA MEDICAL s. r. o., Bratislava, Not set

CUIMED s.r.o, Bratislava, Not set

Privatna urologicka ambulancia, s.r.o., Trencin, Not set

Cancercare Outeniqua, George, Eastern Cape

Dept Radiation and Oncology Tygerberg Academic Hospital, Cape Town, Western Cape

Cancercare Rondebosch Oncology, Rondebosch, Western Cape

Hospital General de Elche - Urologia, Elche, Alicante

Parc Tauli Hospital Universitari - Oncologia, Sabadell, Barcelona

Hospital SAS de Jerez de la Frontera, Jerez de la Frontera, Cádiz

Hospital de Manacor - Urologia, Manacor, Illes Baleares

Hospital Universitari Son Espases - Oncologia, Palma De Mallorca, Illes Baleares

Hospital Universitario Fundacion Alcorcon - Urologia, Alcorcón, Madrid

Hospital del Mar, Barcelona, Not set

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set

Hospital Clínic i Provincial de Barcelona, Barcelona, Not set

Hospital de la Santa Creu i de Sant Pau | Oncología, Barcelona, Not set

Hospital Universitari de Bellvitge (HUB), Barcelona, Not set

Hospital San Pedro de Alcántara - Oncologia, Cáceres, Not set

Hospital Universitario Reina Sofia - Oncologia, Córdoba, Not set

Hospital Universitario Lucus Augusti - Urologia, Lugo, Not set

Hospital General Universitario Gregorio Maranon | Oncologia, Madrid, Not set

Hospital Universitario Ramon Y Cajal - Oncologia, Madrid, Not set

Fundacion Jimenez Diaz (Clinica de la Concepcion), Madrid, Not set

Hospital Clinico Universitario San Carlos | Oncologia, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario Virgen De La Victoria - Oncology, Málaga, Not set

Hospital Clínico de Salamanca, Salamanca, Not set

Hospital Universitario Virgen Del Rocio S.L. - Oncologia, Sevilla, Not set

Instituto Valenciano de Oncología, Valencia, Not set

Hospital Arnau De Vilanova De Valencia - Oncologia, Valencia, Not set

Sahlgrenska Universitetssjukhuset, Goteborg, Not set

Skånes Universitetssjukhus Malmö, Malmö, Not set

Karolinska Universitetssjukhuset, Stockholm, Not set

Norrlands Universitetssjukhus, Umea, Umea, Not set

Akademiska Sjukhuset, Uppsala, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Kaohsiung

China Medical University Hospital, Taichung, Not set

Taichung Veterans General Hospital, Taichung, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Chang Gung Memorial Hospital at Linkou, Taoyuan, Not set

Gazi Universitesi Tip Fakultesi, Ankara, Not set

TC Saglik Bakanligi Goztepe ProfDr Suleyman Yalcin Sehir Has, Istanbul, Not set

CNE "Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of the Cherkasy Regional Council", Cherkasy, Not set

Regional communal non-profit enterprise 'Chernivtsi regional clinical hospital' - Urological department, Chernivtsi, Not set

Municipal Non-commercial Enterprise 'City Clinical Hospital #4' of Dnipro City Council - City ?hemotherapy ?enter, Dnipro, Not set

Regional Medical Clinical Center of Urology and Nephrology n.a. V. I. Shapoval - Department of Oncologic Urology #5, Kharkiv, Not set

Kyiv City Hospital #3 - Department of Urology, Kyiv, Not set

SE "Academician O.F. Vozianov Institute of Urology" of NAMSU - Division of Reconstructive Urology and Advanced Technologies, Kyiv, Not set

Transkarpathian Regional Oncology Center, Uzhgorod, Not set

Royal Berkshire NHS Foundation Trust¦Royal Berkshire Hospital - Oncology, Reading, Berkshire

Prince Philip Hospital, Llanelli, Carmarthenshire

East Suffolk and North Essex NHS Foundation Trust¦Colchester General Hospital - Oncology Trials Unit, Colchester, Essex

Clatterbridge Centre for Oncology, Bebington, Merseyside

Scunthorpe General Hospital, Scunthorpe, North East Lincolnshire

Dudley Group NHS Foundation Trust ¦Russells Hall Hopsital - Oncology, Dudley, West Midlands

Calderdale and Huddersfield NHS Foundation Trust¦Huddersfield Royal Infirmary - Oncology, Huddersfield, West Yorkshire

Mid Yorkshire Teaching NHS Trust¦Pinderfields Hospital - Oncology, Wakefield, West Yorkshire

Cardiff and Vale University Health Board | University Hospital of Wales - Nephrology and Transplant, Cardiff, Not set

Beatson West of Scotland Cancer Centre, Glasgow, Not set

University College London Hospitals NHS Foundation Trust, London, Not set

Charing Cross Hospital, London, Not set

Conditions: Cancer

Learn More ›

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

NCT05485961

Recruiting

This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: 84000149 - Nephrology Consultants, LLC, Huntsville, Alabama +303 locations

84000149 - Nephrology Consultants, LLC, Huntsville, Alabama

84000340 - DaVita Clinical Research Montgomery, Montgomery, Alabama

84000552 - AKDHC Medical, Glendale, Arizona

84000178 - Kidney Disease Medical Group, Glendale, Arizona

84000231 - AKDHC Medical, Phoenix, Arizona

84000286 - AKDHC Medical, Tucson, Arizona

84000145 - National Institute of Clinical Research, Bakersfield, California

84000151 - National Institute of Clinical Research, Bakersfield, California

84000277 - Amicis Research Center, Beverly Hills, California

84000241 - California Institute of Renal Research, Chula Vista, California

84000462 - Davita Fullerton Dialysis Center, Fullerton, California

84000574 - National Institute of Clinical Research, Inc., Fullerton, California

84000464 - St. Jude Medical Center, Garden Grove, California

84000573 - National Institute of Clinical Research, Inc., Garden Grove, California

84000152 - National Institute of Clinical Research, Garden Grove, California

84000531 - Sherman Medical Group, Inc, Glendale, California

84000230 - Kidney Disease Medical Group, Glendale, California

84000379 - Renal Consultants Medical Group, Granada Hills, California

84000631 - Balboa Research, La Jolla, California

84000221 - California Institute of Renal Research, La Mesa, California

84000235 - California Institute of Renal Research, La Mesa, California

84000198 - Southern California Medical Research Center, La Palma, California

84000467 - Southern California Medical Research Center, La Palma, California

84000329 - Academic Medical Research Institute, Los Angeles, California

84000439 - National Institute of Clinical Research, Inc., Los Angeles, California

84000158 - DaVita Carabello Dialysis Center, Los Angeles, California

84000175 - Renal Medical Associates/NARI, Lynwood, California

84000279 - Amicis Research Center, Northridge, California

84000533 - FORMAT Medical Research, Oxnard, California

84000331 - Van Buren Dialysis Center, Riverside, California

84000228 - National Nephrology Alliance Research - Riverside, Riverside, California

84000492 - Central Coast Nephrology Medical Corp, Salinas, California

84000238 - California Institute of Renal Research, San Diego, California

84000143 - California Institute of Renal Research, San Diego, California

84000330 - North America Research Institute, San Dimas, California

84000341 - North America Research Institute, San Dimas, California

84000281 - Satellite Healthcare, San Jose, California

84000440 - Nephrology Educational Services, Tarzana, California

84000536 - Valiance Clinical Research, Tarzana, California

84000278 - Amicis Research Center, Vacaville, California

84000323 - National Institute of Clinical Research, Inc, Victorville, California

84000174 - DaVita Vista Del Sol Dialysis, Victorville, California

84000589 - Western Nephrology, Arvada, Colorado

84000454 - Kidney Associates of Colorado, P.C., Denver, Colorado

84000223 - Colorado Kidney Care, Denver, Colorado

84000176 - Greater Hartford Nephrology, LLC, Bloomfield, Connecticut

84000173 - Nephrology and Hypertension Associates PC, Middlebury, Connecticut

84000494 - Nephrology Associates (Delaware), Newark, Delaware

84000441 - Boca Raton Regional - Research Physicians Network Alliance, Boca Raton, Florida

84000779 - Nova Clinical Research, LLC, Bradenton, Florida

84000661 - Access Research Institute, Brooksville, Florida

84000193 - Horizon Research Group LLC, Coral Gables, Florida

84000443 - South Florida Nephrology Group, PA, Coral Springs, Florida

84000597 - Family First Medical Research Center, Hialeah Gardens, Florida

84000650 - Advanced Medical Research Group, Hollywood, Florida

84000406 - Elixia Pines, Hollywood, Florida

84000140 -South Florida Research Institute, Lauderdale Lakes, Florida

84000599 - South Florida Research Organization LLC, Medley, Florida

84000527 - Floridian Clinical Research, Miami Lakes, Florida

84000495 - Total Research Group, LLC, Miami, Florida

84000663 - Iconic Clinical Research Center, Miami, Florida

84000362 - Kidney and Hypertension Specialists of Miami, Miami, Florida

84000182 - Nephrology Associates of South Miami, Miami, Florida

84000400 - Elixia Central Florida, Orlando, Florida

84000139 - Genesis Clinical Research, Tampa, Florida

84000532 - Florida Kidney Specialists, Temple Terrace, Florida

84000426 - Florida Premier Research Institute, Winter Park, Florida

84000366 - Southwest Georgia Nephrology Clinic, Albany, Georgia

84000326 - Coastal Medical Research, LLC, Brunswick, Georgia

84000157 - Renal Associates LLC, Columbus, Georgia

84000327 - American Clinical Trials, Douglasville, Georgia

84000582 - Georgia Nephrology, Lawrenceville, Georgia

84000194 - Atekha Nephrology Clinic LLC, Statesboro, Georgia

84000453 - Nephrology Physician's LLC, Mishawaka, Indiana

84000534 - Dunes Clinical Research LLC, Sioux City, Iowa

84000374 - Kansas Nephrology Physicians, PA, Wichita, Kansas

84000554 - Nephrology Associates of Kentuckiana, PSC, Louisville, Kentucky

84000550 - Renal Associates of Baton Rouge, Baton Rouge, Louisiana

84000220 - Massachusetts General Hospital, Boston, Massachusetts

84000465 - Paragon Health, Inc, Kalamazoo, Michigan

84000408 - Michigan Kidney Consultants, PC, Pontiac, Michigan

84000171 - St. Clair Nephrology Research, Roseville, Michigan

84000237 - Center for Advanced Kidney Research, PLC, Saint Clair Shores, Michigan

84000146 - DCR Edina, Minneapolis, Minnesota

84000338 - DCR Edina, Minneapolis, Minnesota

84000225 - Southwest Mississippi Nephrology PLLC, Brookhaven, Mississippi

84000153 - Nephrology Associates, PC, Columbus, Mississippi

84000144 - Nephrology and Hypertension Associates Ltd, Tupelo, Mississippi

84000147 - Clinical Research Consultants, Kansas City, Missouri

84000377 - DCI-Rockhill, Kansas City, Missouri

84000328 - GSR Enterprises, Inc., Lincoln, Nebraska

84000222 - Great Plains Health - Nephrology, North Platte, Nebraska

84000420 - DaVita Clinical Research - Henderson, Henderson, Nevada

84000337 - Kidney Specialists of Southern Nevada, Las Vegas, Nevada

84000148 - Sierra Nevada Specialty Care, Reno, Nevada

84000141 - Seacoast Kidney and Hypertension Specialists, Portsmouth, New Hampshire

84000436 - Hypertension & Nephrology Association, Eatontown, New Jersey

84000452 - New Jersey Kidney Care, Jersey City, New Jersey

84000155 - DaVita Clinic Research Bronx, Bronx, New York

84000276 - Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, New York

84000184 - Mattoo & Bhat Medical Associates, P.C., College Point, New York

84000393 - NYU Langone Hospital - Long Island, Mineola, New York

84000191 - Metrolina Nephrology Associates, PA, Charlotte, North Carolina

84000150 - Durham Nephrology Associates, PA, Durham, North Carolina

84000232 - East Carolina University, Greenville, North Carolina

84000410 - North Carolina Nephrology, PA, Raleigh, North Carolina

84000548 - HNC Dialysis, Ltd., Columbus, Ohio

84000234 - Northeast Clinical Research Center, LLC, Bethlehem, Pennsylvania

84000192 - Columbia Nephrology, Columbia, South Carolina

84000229 - DaVita Clinical Research, Spartanburg, South Carolina

84000547 - Southeast Renal Research Institute, Chattanooga, Tennessee

84000361 - Dialysis Clinic Inc - University Nephology, Knoxville, Tennessee

84000180 - Knoxville Kidney Center PLLC, Knoxville, Tennessee

84000451 - Cussimanio Research Group LLC, Austin, Texas

84000438 - Research Management, Inc., Austin, Texas

84000549 - MW Clinical Research Center, Beaumont, Texas

84000457 - US Renal Care, Dallas, Texas

84000354 - Davita Clinical Research, El Paso, Texas

84000421 - DaVita Clinical Research - Horizon, El Paso, Texas

84000458 - Fort Worth Renal Group, Fort Worth, Texas

84000649 - Clinical Research Strategies, Houston, Texas

84000350 - DaVita Clinical Research, Houston, Texas

84000498 - DaVita Clinical Research, Houston, Texas

84000598 - Aqua Research Institute, Houston, Texas

84000450 - Houston Medical Research Institute, LLC, Houston, Texas

84000360 - Clinical Research Strategies, Inc., Houston, Texas

84000196 - Southwest Houston Research, Houston, Texas

84000634 - Prime Clinical Research, Inc., Mansfield, Texas

84000373 - Gamma Medical Research, Inc., McAllen, Texas

84000324 - National Institute of Clinical Research, Inc., San Antonio, Texas

84000351 - DaVita Clinical Research, San Antonio, Texas

84000419 - Davita Clinical Research, San Antonio, Texas

84000553 - DCR-San Antonio Stone Oak, San Antonio, Texas

84000339 - DaVita Clinical Research North Houston, Shenandoah, Texas

84000660 - Medrasa Clinical Research, Sherman, Texas

84000535 - DCR-Norfolk Great Bridge, Chesapeake, Virginia

84000424 - Nephrology Associates of Northern Virginia Inc, Fairfax, Virginia

84000138 - Peninsula Kidney Associates, Hampton, Virginia

84000156 - Tidewater Kidney Specialists, Norfolk, Virginia

84000336 - Nephrology and Hypertension Associates, Bluefield, West Virginia

03600023 - Royal North Shore Hospital (RNSH), Saint Leonards, New South Wales

03600017 - Concord Repatriation General Hospital, Sydney, New South Wales

03600037 - Cairns Hospital, Cairns, Queensland

03600021 - Sunshine Coast University Private Hospital, Nambour, Queensland

03600014 - Princess Alexandra Hospital, Woolloongabba, Queensland

03600013 - Monash Medical Centre, Clayton, Victoria

03600011 - Sunshine Hospital, St Albans, Victoria

03600050 - Fiona Stanley Hospital, Murdoch, Not set

03600021 - Sunshine Coast University Private Hospital, Nambour, Not set

03600020 - Gold Coast University Hospital, Southport, Not set

03600012 - Westmead Hospital, Westmead, Not set

03600048 - Wollongong Renal Unit, Wollongong, Not set

05600011 - Onze-Lieve-Vrouwziekenhuis VZW, Aalst, Not set

05600005 - Imelda Ziekenhuis, Bonheiden, Not set

05600004 - AZ Sint-Lucas, Gent, Not set

05600013 - Centre Hospitalier Universitaire de Tivoli, La Louvière, Not set

05600012 - Universitair Ziekenhuis Leuven, Leuven, Not set

05600003 - CHR de la Citadelle, Liège, Not set

05600018 - AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke, Roeselare, Not set

10000002 - Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD, Lom, Not set

10000007 - UMHAT Plovdiv, Plovdiv, Not set

10000001 - Medical Center - Smolyan OOD, Smolyan, Not set

10000005 - Dialysis Center VIA DIAL OOD, Stara Zagora, Not set

12400008 - University of Alberta Hospital, Edmonton, Alberta

12400021 - Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia

12400026 - St. Josephs Healthcare Hamilton, Hamilton, Ontario

12400009 - Kingston Health Sciences Centre, Kingston, Ontario

12400030 - London Health Sciences Centre - University Hospital, London, Ontario

12400024 - Lakeridge Health Oshawa, Oshawa, Ontario

12400023 - McGill University Health Centre, Montreal, Quebec

12400015 - Hôpital du Sacré-Cœur-de-Montréal, Montréal, Quebec

12400014 - Maisonneuve-Rosemont Hospital, Montréal, Not set

12400031 - CHUM - Centre hospitalier de l'Universite de Montreal, Montréal, Not set

12400032 - St. Michaels Hospital, Toronto, Not set

12400027 - Seven Oaks Hospital, Winnipeg, Not set

15600014 - Peking University First Hospital, Beijing, Not set

15600036 - Beijing Tsinghua Chang Gung Hospital, Beijing, Not set

15600026 - Affiliated Hospital of Jiangsu University, Zhenjiang City, Not set

20800009 - Aalborg Universitetshospital, Aalborg, Not set

20800010 - Herlev Hospital, Herlev, Not set

20800008 - Gødstrup Hospital, Herning, Not set

20800011 - Trail Nation: Nordsjællands Hospital, Hillerød, Not set

25000011 - CHU Amiens - Nephrology Dialysi Transplantation Department, Amiens, Not set

25000014 - CHU de Saint-Étienne - Hôpital Nord, Aura, Not set

25000027 - Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche, Brest, Not set

25000013 - CHU de Caen, Caen, Not set

25000033 - CHU de Limoges, Limoges Cedex, Not set

25000018 - Centre Hospitalier Universitaire Montpellier - Hôpital Lapeyronie, Montpellier, Not set

25000025 - AURA Paris - Plaisance, Paris, Not set

25000019 - Centre Hospitalier Universitaire (CHU) de Reims - Hopital Maison Blanche, Reims, Not set

25000016 - AURA St Quen Dialysis centre, Saint-Ouen, Not set

25000029 - Hôpitaux Universitaires de Strasbourg - Hôpital Civil, Strasbourg, Not set

25000012 - CHU Rangueil, Toulouse, Not set

27600047 - Charite-Universitatsmedizin Berlin, Berlin, Not set

27600041 - Nierenzentrum Bad König, Hessen, Not set

27600039 - Westpfalz Klinikum GmbH, Kaiserslautern, Not set

27600022 - UKSH - Universitatsklinik Schleswig-Holstein, Kiel, Not set

27600021 - Kuratorium fuer Dialyse und Nierentransplantation e.V. - KfH-Nierenzentrum - St. Georg, Leipzig, Not set

27600040 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Not set

27600020 - Nephrologisches Zentrum Villingen-Schwenningen, Villingen-Schwenningen, Not set

30000015 - University Hospital of Alexandroupolis, Alexandroupolis, Not set

30000012 - University General Hospital of Heraklion, Crete, Not set

30000004 - University General Hospital of Ioannina, Ioánnina, Not set

30000002 - General Hospital of Ioannina G. Hatzikosta, Ioánnina, Not set

30000014 - Nephrological Clinic University Hospital, University of Thessaly, Larissa, Not set

30000008 - University Hospital of Patras, Rio, Not set

30000005 - Aristotle University, Hippokration, Thessaloniki, Not set

30000003 - AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloníki, Not set

30000006 - General Hospital of Thessaloniki, Agios Pavlos, Thessaloníki, Not set

30000009 - Papageorgiou General Hospital of Thessaloniki, Thessaloníki, Not set

30000011 - Nephrology Department G. Papanikolaou General Hospital, Thessaloníki, Not set

30000016 - General Hospital of Arta, Árta, Not set

34800012 - B. Braun Avitum - 14. Dialízisközpont Kistarcs, Kistarcsa, Not set

37600008 - Carmel Medical Center, Haifa, Not set

37600012 - Edith Wolfson Medical Center, H̱olon, Not set

37600010 - Rabin Medical Center, Petah Tikva, Not set

37600011 - Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center ), Ramat Gan, Not set

37600009 - Ichilov Hospital-Tel-Aviv Sourasky Medical Center, Tel Aviv, Not set

37600002 - Medical Research & Development Fund for Health Services, PORIYA Hospital, Tiberias, Not set

37600013 - Ziv Medical Center, Zefat, Not set

38000025 - ASST degli Spedali Civili di Brescia, Brescia, Not set

38000031 - Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta, Caserta, Not set

38000061 - Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna, Ferrara, Not set

38000074 - Ospedale Santa Maria Annunziata, Florence, Not set

38000027 - A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp, Foggia, Not set

38000024 - ASST di Lecco - Presidio Ospedaliero A. Manzoni di Lecco, Lecco, Not set

38000029 - Università degli Studi di Messina, Messina, Not set

38000023 - IRCCS Ospedale San Raffaele, Milano, Not set

38000069 - Ospedale Maggiore di Novara, Novara, Not set

38000019 - ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS, Pavia, Not set

38000026 - University of Verona, Peschiera Del Garda, Not set

38000064 - AUSL Piacenza Hospital-Unit Nephrology Dialysis, Dept of Medicine, Piacenza, Not set

38000032 - Ospedale Santo Stefan, Prato, Not set

38000067 - Rimini Hospital, Rimini, Not set

38000016 - Ospedale Casa Sollievo della Sofferenza (CSS), San Giovanni Rotondo, Not set

38000020 - Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set

39200053 - Daiyukai Daiichi Hospital, Ichinomiya-shi, Aichi

39200044 - Juntendo University Urayasu Hospital, Urayasu-shi, Chiba-ken

39200046 - Steel Memorial Yawata Hospital, Kitakyushu-shi, Fukuoka

39200048 - Maebashi Hirosegawa Clinic, Maebashi-shi, Gunma

39200049 - Joumou Ohashi Clinic, Maebashi-shi, Gunma

39200045 - Teine Urological Clinic, Sapporo-shi, Hokkaido

39200054 - Omi freai Hospital, Kusatsu-shi, Shiga

39200027 - Tokyo Womens Med University, Shinjuku-Ku, Tokyo

39200042 - Matsunami General Hospital, Hashima-gun, Not set

39200041 - Ishikiriseiki Hospital, Higashiosaka-shi, Not set

39200055 - Miki Internal Medicine Urology Clinic, Hokkaido, Not set

39200033 - Tokyo Medical University Ibaraki Medical Center, Inashiki-gun, Not set

39200043 - Ueyama Hospital, Kagoshima-shi, Not set

39200038 - St. Mary's Hospital, Kurume-shi, Not set

39200021 - Kurume University Hospital, Kurume, Not set

39200028 - Rakuwakai Otowa Kinen Hospital, Kyoto-Shi, Not set

39200037 - Nagaoka Red-Cross Hospital, Nagaoka-Shi, Not set

39200035 - Daido Hospital, Nagoya-shi, Not set

39200020 - Chubu Rosai Hospital, Nagoya, Not set

39200026 - Omihachiman Community Medical Center - Kidney Center, Omihachiman, Not set

39200032 - Oguranaika Jin Cinic, Oyama-shi, Not set

39200029 - Ibaraki Seinan Medical Center Hospital, Sakaimachi, Not set

39200031 - Kurosawa Hospital, Takasaki-Shi, Not set

39200034 - Kikuchi Medical Clinic, Tsukuba-shi, Not set

39200030 - St.Hill Hospital, Ube-shi, Not set

39200051 - Bosei Kannai Clinic, Yokohama-shi, Not set

39200036 - Sanin Rosai Hospital, Yonago-shi, Not set

41000002 - SMG - SNU Boramae Medical Center, Ilsan-gu, Seoul

41000006 - Hallym University Sacred Heart Hospital, Anyang-si, Not set

41000004 - Keimyung University Dongsan Medical Center, Daegu, Not set

41000001 - Gangnam Severance Hospital, Gangnam-gu, Not set

41000009 - National Health Insurance Service - Ilsan Hospital, Goyang-si, Not set

41000008 - Konkuk University Medical Center, Gwangju, Not set

41000005 - Seoul National University Hospital, Seoul, Not set

41000012 - Severance Hospital, Yonsei University, Seoul, Not set

41000007 - Yonsei University - Wonju Severance Christian Hospital, Wonju-si, Not set

61600011 - Powiatowy Szpital Specjalistyczny w Stalowej Woli, Stalowa Wola, Not set

62000011 - Unidade Local de Saúde de Braga, E. P. E., Braga, Not set

62000010 - Unidade Local de Saúde de Loures -Odivelas, E. P. E., Loures, Not set

62000009 - Unidade Local de Saúde de São José, E. P. E., Oeiras, Not set

62000005 - Unidade Local de Saúde de Santo António, E. P. E., Porto, Not set

62000007 - Unidade Local de Saúde do Estuário do Tejo, E. P. E., Vila Franca De Xira, Not set

64200014 - SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center, Bucharest, Not set

64200024 - Fundeni Clinical Institute, Bucuresti, Not set

64200016 - Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta), Constanta, Not set

64200005 - Spital Judetean de Urgenta Satu Mare, Satu Mare, Not set

72400007 - Hospital Universitari Arnau de Vilanova, Lleida, Not set

75200001 - Uppsala Universitet - Akademiska Sjukhuset, Uppsala, Not set

82600041 - University Hospitals Birmingham NHS Foundation Trust - Birmingham Heartlands Hospital (BHH), Birmingham, Not set

82600027 - Bradford Teaching Hospitals NHS Foundation Trust, Bradford, Not set

82600023 - University Hospital Coventry and Warwickshire, Coventry, Not set

82600060 - University Hospitals of Derby and Burton NHS Foundation Trust - Royal Derby Hospital, Derby, Not set

82600022 - Dorset County Hospital NHS Foundation Trust - Dorset County Hospital (DCH), Dorchester, Not set

82600024 - Royal Liverpool University Hospital, Liverpool, Not set

82600028 - Altnagelvin Area Hospital, Londonderry, Not set

82600026 - William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital, London, Not set

82600032 - King´s College NHS Trust, London, Not set

82600034 - St George's University Hospitals NHS Foundation Trust - St G, London, Not set

82600042 - Hammersmith Hospital Imperial College Healthcare NHS Trust -Hammersmith Hospital - West London Renal and Transplant Centre, London, Not set

82600029 - Northern Care Alliance NHS Foundation Trust - Salford Royal NHS Foundation Trust-Salford Care Organisation, Salford, Not set

82600039 - The Shrewsbury and Telford Hospital NHS Trust (SaTH) - Royal Shrewsbury Hospital, Shrewsbury, Not set

82600025 - Royal Stoke University Hospital, Stoke-on-Trent, Not set

82600049 - The Royal Wolverhampton NHS Trust - New Cross Hospital, Wolverhampton, Not set

Conditions: Atherosclerotic Cardiovascular Disease, End Stage Kidney Disease, Atherosclerotic Cardiovascular Disease in Patients With ESKD

Learn More ›

ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE

NCT05746559

Recruiting

The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent cardiac surgery with CPB.

Gender:

ALL

Ages:

Between 18 years and 90 years

Trial Updated:

06/18/2025

Locations: Research Site, Tucson, Arizona +214 locations

Research Site, Tucson, Arizona

Research Site, Orange, California

Research Site, San Francisco, California

Research Site, Stanford, California

Research Site, Aurora, Colorado

Research Site, Washington, District of Columbia

Research Site, Gainesville, Florida

Research Site, Orlando, Florida

Research Site, Weston, Florida

Research Site, Atlanta, Georgia

Research Site, Chicago, Illinois

Research Site, Fort Wayne, Indiana

Research Site, Indianapolis, Indiana

Research Site, Louisville, Kentucky

Research Site, Boston, Massachusetts

Research Site, Springfield, Massachusetts

Research Site, Detroit, Michigan

Research Site, Kansas City, Missouri

Research Site, Saint Louis, Missouri

Research Site, Lincoln, Nebraska

Research Site, Haddon Heights, New Jersey

Research Site, Rochester, New York

Research Site, Valhalla, New York

Research Site, Durham, North Carolina

Research Site, Winston-Salem, North Carolina

Research Site, Fargo, North Dakota

Research Site, Cleveland, Ohio

Research Site, Columbus, Ohio

Research Site, Philadelphia, Pennsylvania

Research Site, Charleston, South Carolina

Research Site, Dallas, Texas

Research Site, Houston, Texas

Research Site, Plano, Texas

Research Site, San Antonio, Texas

Research Site, Salt Lake City, Utah

Research Site, Charlottesville, Virginia

Research Site, Richmond, Virginia

Research Site, Seattle, Washington

Research Site, Tacoma, Washington

Research Site, Wisconsin Rapids, Wisconsin

Research Site, Buenos Aires, Not set

Research Site, Caba, Not set

Research Site, Ciudad Autónoma de Bs. As., Not set

Research Site, Cordoba, Not set

Research Site, Corrientes, Not set

Research Site, Córdoba, Not set

Research Site, San Luis, Not set

Research Site, Santa Fé, Not set

Research Site, Adelaide, Not set

Research Site, Brisbane, Not set

Research Site, Canberra, Not set

Research Site, Heidelberg, Not set

Research Site, Monash, Not set

Research Site, Murdoch, Not set

Research Site, Southport, Not set

Research Site, Vienna, Not set

Research Site, Belo Horizonte, Not set

Research Site, Brasillia, Not set

Research Site, Campinas, Not set

Research Site, Fortaleza, Not set

Research Site, Porto Alegre, Not set

Research Site, Recife, Not set

Research Site, Ribeirão Preto, Not set

Research Site, Rio de Janeiro, Not set

Research Site, S.J. Do Rio Preto, Not set

Research Site, Salvador, Not set

Research Site, Sao Paulo, Not set

Research Site, São Paulo, Not set

Research Site, Edmonton, Alberta

Research Site, Winnipeg, Manitoba

Research Site, Saint John, New Brunswick

Research Site, Hamilton, Ontario

Research Site, Kingston, Ontario

Research Site, Toronto, Ontario

Research Site, Montreal, Quebec

Research Site, Montréal, Quebec

Research Site, Beijing, Not set

Research Site, Fuzhou, Not set

Research Site, Gaozhou, Not set

Research Site, Guangzhou, Not set

Research Site, Hangzhou, Not set

Research Site, Huai'an, Not set

Research Site, Ningbo, Not set

Research Site, Shanghai, Not set

Research Site, Shenzhen, Not set

Research Site, Tianjin, Not set

Research Site, Wuhan, Not set

Research Site, Xi'an, Not set

Research Site, Zhengzhou City, Not set

Research Site, Zhengzhou, Not set

Research Site, Zunyi, Not set

Research Site, Bordeaux Cedex, Not set

Research Site, Dijon Cedex, Not set

Research Site, Montpellier, Not set

Research Site, Toulouse Cedex 3, Not set

Research Site, Dresden, Not set

Research Site, Essen, Not set

Research Site, Frankfurt am Main, Not set

Research Site, Giessen, Not set

Research Site, Halle (Saale), Not set

Research Site, Heidelberg, Not set

Research Site, Jena, Not set

Research Site, Muenster, Not set

Research Site, München, Not set

Research Site, Stuttgart, Not set

Research Site, Trier, Not set

Research Site, Alexandroupolis, Not set

Research Site, Athens, Not set

Research Site, Thessaloniki, Not set

Research Site, Hong Kong, Not set

Research Site, Bangalore, Not set

Research Site, Delhi, Not set

Research Site, Gurgaon, Not set

Research Site, Hyderabad, Not set

Research Site, Mysuru, Not set

Research Site, Secunderabad, Not set

Research Site, Haifa, Not set

Research Site, Petah Tikva, Not set

Research Site, Ramat Gan, Not set

Research Site, Bari, Not set

Research Site, Firenze, Not set

Research Site, Milano, Not set

Research Site, Milan, Not set

Research Site, Napoli, Not set

Research Site, Bunkyo-ku, Not set

Research Site, Chuo-ku, Not set

Research Site, Kamakura-shi, Not set

Research Site, Kawasaki-shi, Not set

Research Site, Minato-ku, Not set

Research Site, Okayama-shi, Not set

Research Site, Sagamihara-shi, Not set

Research Site, Suginami, Not set

Research Site, Urayasu, Not set

Research Site, Anyang-si, Not set

Research Site, Bucheon-si, Not set

Research Site, Busan, Not set

Research Site, Daegu, Not set

Research Site, Seongnam-si, Not set

Research Site, Seoul, Not set

Research Site, Groningen, Not set

Research Site, Maastricht, Not set

Research Site, Rotterdam, Not set

Research Site, Białystok, Not set

Research Site, Bielsko-Biała, Not set

Research Site, Chrzanów, Not set

Research Site, Grudziądz, Not set

Research Site, Katowice, Not set

Research Site, Kraków, Not set

Research Site, Poznań, Not set

Research Site, Szczecin, Not set

Research Site, Tychy, Not set

Research Site, Warszawa, Not set

Research Site, Łódź, Not set

Research Site, Coimbra, Not set

Research Site, Lisboa, Not set

Research Site, A Coruna, Not set

Research Site, Barcelona, Not set

Research Site, Córdoba, Not set

Research Site, Madrid, Not set

Research Site, Majadahonda, Not set

Research Site, Navarra, Not set

Research Site, Santander, Not set

Research Site, Sevilla, Not set

Research Site, Valencia, Not set

Research Site, Valladolid, Not set

Research Site, Hualien City, Not set

Research Site, Kaohsiung, Not set

Research Site, New Taipei, Not set

Research Site, Taichung, Not set

Research Site, Tainan City, Not set

Research Site, Taipei City, Not set

Research Site, Taipei, Not set

Research Site, Ankara, Not set

Research Site, Antalya, Not set

Research Site, Istanbul, Not set

Research Site, Menemen/Izmir, Not set

Research Site, Odunpazarı, Not set

Research Site, Cambridge, Not set

Research Site, Clydebank, Not set

Research Site, Edinburgh, Not set

Research Site, London, Not set

Research Site, Newcastle upon Tyne, Not set

Conditions: Chronic Kidney Disease, CKD, Cardiac Disease, Cardiopulmonary Bypass

Learn More ›

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

NCT06102902

Recruiting

This phase I trial tests the safety, best dose, and effectiveness of ZEN003694 in combination with cetuximab and encorafenib in treating patients with colorectal cancer that has not responded to previous treatment (refractory), that has come back after a period of improvement (relapsed), and that has spread from where it first started (primary site) to other places in the body (metastatic). ZEN003694 is a protein inhibitor that binds to BET proteins. When ZEN003694 binds to BET proteins, it disr... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: Los Angeles General Medical Center, Los Angeles, California +11 locations

Conditions: Metastatic Colorectal Adenocarcinoma, Refractory Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Recurrent Colorectal Adenocarcinoma

Learn More ›

AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

NCT06333951

Recruiting

The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted thoracic tumors. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted thoracic... Read More

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

06/18/2025

Locations: Comprehensive Blood and Cancer Center, Bakersfield, California +69 locations

Comprehensive Blood and Cancer Center, Bakersfield, California

City of Hope National Medical Center, Duarte, California

Translational Research in Oncology US Inc, Trio Central Pharmacy, Los Angeles, California

University of California Irvine, Orange, California

University of California Los Angeles, Santa Monica, California

Rocky Mountain Cancer Centers, Denver, Colorado

Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut

HealthPartners Institute, Saint Paul, Minnesota

Saint Lukes Hospital of Kansas City, Kansas City, Missouri

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada

New York University Grossman School of Medicine, New York, New York

Perlmutter Cancer Center at New York University Langone Hospital----Long Island, New York, New York

Hightower Clinical, Oklahoma City, Oklahoma

University of Tennessee Medical Center Knoxville, Knoxville, Tennessee

United States Oncology Regulatory Affairs Corporate Office, Nashville, Tennessee

Texas Oncology - Dallas Fort Worth, Dallas, Texas

US Oncology Research Investigational Products Center, Dallas, Texas

Oncology Consultants Cancer Center, Houston, Texas

Texas Oncology Northeast Texas, Tyler, Texas

Virginia Cancer Specialists PC, Fairfax, Virginia

Northwest Medical Specialties, PLLC, Tacoma, Washington

Orange Health Service, Orange, New South Wales

The Queen Elizabeth Hospital, Woodville South, South Australia

Medizinische Universitaet Graz, Graz, Not set

Medizinische Universitaet Innsbruck, Innsbruck, Not set

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, Not set

Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Rio Grande Do Sul

Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp, São Paulo, Not set

Princess Margaret Cancer Centre, Toronto, Ontario

Mengchao Hepatobiliary hospital of Fujian Medical University, Fuzhou, Fujian

Guangdong Provincial Peoples Hospital, Guangzhou, Guangdong

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei

Jilin Cancer Hospital, Changchun, Jilin

Beijing Cancer Hospital, Beijing, Not set

Institut Bergonie, Bordeaux, Not set

Hopital de la Timone, Marseille, Not set

Institut de Cancerologie de l Ouest Rene Gauducheau, Saint Herblain, Not set

Gustave Roussy, Villejuif, Not set

Universitaetsklinikum Essen, Essen, Not set

Thoraxklinik Heidelberg, Heidelberg, Not set

Universitaetsklinikum Wuerzburg, Wuerzburg, Not set

Alexandra Hospital, Athens, Not set

Saint Luke Hospital, Thessaloniki, Not set

General Hospital Of Thessaloniki Papageorgiou, Thessaloniki, Not set

Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set

Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Not set

Fondazione IRCCS Istituto Nazionale dei Tumori, Alessandria, Not set

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set

IRCCS Istituto Clinico Humanitas, Rozzano (MI), Not set

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona, Not set

Aichi Cancer Center, Nagoya-shi, Aichi

National Cancer Center Hospital East, Kashiwa-shi, Chiba

Shizuoka Cancer Center, Sunto-gun, Shizuoka

Wakayama Medical University Hospital, Wakayama-shi, Wakayama

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Radboud Universitair Medisch Centrum, Nijmegen, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Narodowy Instytut Onkologii im Marii Slodowskiej Curie Panstwowy Instytut Badawczy, Gliwice, Not set

Futuremeds spolka z ograniczona odpowiedzialnoscia, Kraków, Not set

Instytut Centrum Zdrowia Matki Polki, Lodz, Not set

Centrum Medyczne Hope Clinic Sebastian Szklener, Lublin, Not set

Hospital Universitari Vall d Hebron, Barcelona, Cataluña

Hospital Clinic i Provincial de Barcelona, Barcelona, Cataluña

Hospital Universitario 12 de Octubre, Madrid, Not set

National Cheng Kung University Hospital, Tainan, Not set

Taipei Veterans General Hospital, Taipei, Not set

Adana Sehir Egitim ve Arastirma Hastanesi, Adana, Not set

Ankara Bilkent Sehir Hastanesi, Ankara, Not set

Conditions: Thoracic Tumors, Non-small Cell Lung Cancer

Learn More ›

A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma

NCT06637371

Recruiting

The main objective of this study is to assess the safety and tolerability of AMG 691 as single doses (healthy participants only) and multiple doses in healthy participants and participants with mild-to-moderate asthma.

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

06/18/2025

Locations: Orange County Research Center, Lake Forest, California +6 locations

Conditions: Asthma

Learn More ›

Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)

NCT06785324

Recruiting

This clinical trial aims to assess the effect of nutrition and exercise on muscle and adiposity in adults with Philadelphia Chromosome (Ph) Negative B-ALL undergoing inpatient induction therapy. Participants will take part in 2 different interventions: * Nutrition Intervention * Physical Exercise Intervention All subjects will be provided with a wearable electronic activity monitor (FitBit®) to assist in recording activity levels in minutes of activity.

Gender:

ALL

Ages:

Between 18 years and 50 years

Trial Updated:

06/18/2025

Locations: University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

Conditions: Philadelphia Chromosome Negative, B Cell Acute Lymphoblastic Leukemia (B-ALL), B-ALL

Learn More ›

CMSL Ambulatory Sensitive Condition Nudge Study 2

NCT07028398

Recruiting

The project aims to evaluate a nurse-led intervention to reduce inappropriate emergency department (ED) use among adult patients seen at Geisinger's Community Medicine Service Line (CMSL) clinics. The intervention occurs immediately following an appointment where a patient receives a diagnosis of an ambulatory sensitive condition (ASC; i.e., a condition considered to be a risk factor for near-term ED use). The evaluation will compare eligible patients with an ASC who were randomly assigned to receive follow-up outreach (patient portal message or call) from a nurse (who was automatically prompted via the Epic electronic health record system to initiate outreach) with those who were randomly assigned to receive standard care. Analyses will be intent-to-treat. The primary outcome is ED use in the week following the appointment. We ran an earlier version of this intervention (NCT06798389). The current study is modified based on results and clinical guidance. Specifically, more conditions will be included as qualifying ASCs for enrollment. Patients under 30 will be excluded. And rather than calling all patients as in the original study, patient portal messages will be sent to patient portal users (i.e., those with a portal account and 1+ login in the 6 months prior to enrollment). Finally, in the first study, the intervention was differentially effective by age group (\<45, 45-64, 65+). Our primary analysis will be conducted separately by age group, though we will conduct an analysis combining across age groups. We will also run an analysis separately by modality (call, portal message) to determine the effectiveness of each modality individually for eligible patients. We will run the study until we reach at least 4,330 patients in each of the following groups: patients aged 30-45, patients aged 45-64, patients aged 65+, patients eligible for a call, patients eligible for a portal message. Our estimated sample size is at least 4,330x3 = 12,990, because by the time we reach our target in each of the three age groups, we expect we will already have reached 4,330 patients in each of the individual modalities (but if that is not the case, we will continue running the study until we reach 4,330 in each age group and modality). We may be required to stop the study early at the direction of clinical or operational leaders. We will not analyze data before deciding to stop the study. Read Less

Gender:

ALL

Ages:

30 years and above

Trial Updated:

06/18/2025

Locations: Geisinger, Danville, Pennsylvania

Conditions: Behavioral Intervention, Emergency Department Visits, Nurse Care Coordination

Learn More ›

Deep Brain Stimulation Surgery for Movement Disorders

NCT01581580

Recruiting

Background: - Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments. DBS uses a battery-powered device called a neurostimulator (like a pacemaker) that is placed under the skin in the chest. It is used to stimulate the areas of the brain that affect movement. Stimulating these areas helps to block the nerve signals that cause abnormal movements. Researchers also want to record the brain function... Read More

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

06/18/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Parkinson's Disease, Essential Tremor, Dystonia

Learn More ›

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

NCT04550494

Recruiting

This phase II trial studies if talazoparib works in patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and has mutation(s) in deoxyribonucleic acid (DNA) damage response genes who have or have not already been treated with another PARP inhibitor. Talazoparib is an inhibitor of PARP, a protein that helps repair damaged DNA. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing th... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: University of Florida Health Science Center - Gainesville, Gainesville, Florida +3 locations

Conditions: Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Castration-Resistant Prostate Carcinoma, Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8, Metastatic Prostate Carcinoma, Platinum-Sensitive Ovarian Carcinoma, Stage II Pancreatic Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Gastric Carcinoma, Metastatic Malignant Solid Neoplasm, Metastatic Ovarian Carcinoma, Metastatic Pancreatic Carcinoma, HER2-Positive Breast Carcinoma, Locally Advanced Breast Carcinoma, Locally Advanced Gastric Carcinoma, Locally Advanced Malignant Solid Neoplasm, Locally Advanced Ovarian Carcinoma, Locally Advanced Pancreatic Carcinoma, Locally Advanced Prostate Carcinoma, Stage III Ovarian Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8, Recurrent Breast Carcinoma, Recurrent Gastric Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Pancreatic Carcinoma, Recurrent Prostate Carcinoma

Learn More ›

A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus (AMETHYST)

NCT05531565

Recruiting

In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that made it hard to continue. The main objective of the study is to learn about the effect litifilimab has on lowering the activity of the skin disease. Researchers will measure symptoms of CLE over time using a variety of scoring tools. These include the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI), the Cutaneous Lupus Activity of Investigator's Global Assessment-Revised (CLA-IGA-R), and the SELENA-SLEDAI Flare Index (SFI). The main questions researchers want to answer are: * How many participants have a score of 0 or 1 on the CLA-IGA-R looking at skin redness after treatment? * How many participants have their skin disease activity go down by at least 70%? Researchers will also learn more about the safety of litifilimab. They will study how participants' immune systems respond to litifilimab. Additionally, they will measure the effect litifilimab and CLE have on the quality of life of participants using a group of questionnaires. The study will be split into 2 parts - Part A and Part B. Both parts will be done as follows: * After screening, participants will be randomized to receive either litifilimab or placebo for the 1st treatment period. A placebo looks like the study drug but contains no real medicine. * Participants will receive either litifilimab or placebo as injections under the skin once every 4 weeks. * The 1st treatment period will be double blinded which means neither the researchers nor the participants will know if the participants are receiving litifilimab or placebo. * This double blinded treatment period will last 24 weeks, after which the 2nd treatment period will begin. * During the 2nd treatment period, all participants will receive litifilimab for 28 weeks. * After completing treatment in this study, participants that qualify will be given the choice to join the Long-Term Extension study, 230LE305. If they do not, they will move into a follow-up safety period that will last up to 24 weeks. * The total study duration for participants will be up to 80 weeks Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/18/2025

Locations: Pinnacle Research Group, LLC, Anniston, Alabama +255 locations

Pinnacle Research Group, LLC, Anniston, Alabama

UAB Center for Women's Reproductive Health, Birmingham, Alabama

Arizona Arthritis & Rheumatology Research, PLLC, Phoenix, Arizona

The Regents of the University of California, La Jolla, California

Dermatology Research Associates, Los Angeles, California

Clinical Science Institute, Santa Monica, California

Inland Rheumatology Clinical Trials, Inc., Upland, California

Denver Arthritis Clinic, Denver, Colorado

Omega Research Debary, LLC, DeBary, Florida

Centre for Rheumatology, Immunology and Arthritis, Fort Lauderdale, Florida

University of Florida, Gainesville, Florida

Charisma Medical and Research Center, Miami Lakes, Florida

University of Miami Miller School of Medicine, Miami, Florida

Medical Research Center of Miami, Miami, Florida

Rush University Medical Center, Chicago, Illinois

OrthoIllinois, Rockford, Illinois

Dawes Fretzin Clinical Research Group, LLC, Indianapolis, Indiana

LSU Health Sciences Center Shreveport, New Orleans, Louisiana

Tufts Medical Center, Boston, Massachusetts

Brigham And Women's Hospital, Boston, Massachusetts

Essential Dermatology, Natick, Massachusetts

Beacon Clinical Research, LLC, Quincy, Massachusetts

University of Massachusetts, Worcester, Worcester, Massachusetts

David Fivenson, MD, Dermatology, PLLC, Ann Arbor, Michigan

Oakland Hills Dermatology, Auburn Hills, Michigan

AA MRC LLC Ahmed Arif Medical Research Center, Flint, Michigan

Revival Research Institute, LLC, Troy, Michigan

Saint Louis University, Saint Louis, Missouri

University of Nebraska Medical Center, Omaha, Nebraska

Albuquerque Center For Rheumatology, Albuquerque, New Mexico

University of New Mexico School of Medicine, Albuquerque, New Mexico

NYU Langone Brooklyn, Brooklyn, New York

Universal Dermatology, PLLC, Fairport, New York

Northwell Health, Inc. PRIME, Great Neck, New York

Columbia University Medical center, New York, New York

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Duke Dermatology South Durham, Durham, North Carolina

Medication Management, LLC, Greensboro, North Carolina

University of Cincinnati Department of Dermatology, Cincinnati, Ohio

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Ohio State University, Columbus, Ohio

Penn State University Milton S. Hershey Medical Center, Hershey, Pennsylvania

University of Pennsylvania, Philadelphia, Pennsylvania

Vanderbilt University Medical Center, Nashville, Tennessee

Austin Regional Clinic, P.A., Austin, Texas

Precision Comprehensive Clinical Research Solutions, Colleyville, Texas

Metroplex Clinical Research Center, LLC, Dallas, Texas

UT Southwestern Medical Center, Dallas, Texas

North Texas Center for Clinical Research, Frisco, Texas

UTMB Department of Dermatology, Galveston, Texas

University of Texas Health Science Center at Houston, Houston, Texas

Arthritis & Osteoporosis Clinic, Waco, Texas

University of Utah Health Sciences Center, Salt Lake City, Utah

West End Dermatology Associates, Richmond, Virginia

CINME - Centro De Investigaciones Metabolicas, Caba, Buenos Aires

Centro de Investigaciones Medicas Mar del Plata, Mar del Plata, Buenos Aires

Instituto de Investigaciones Clinicas Quilmes, Quilmes, Buenos Aires

APRILLUS Asistencia e Investigacion, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires

Fundacion Respirar, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires

Instituto CAICI, Rosario, Santa Fe

Clinica Mayo de Urgencias Medicas Cruz Blanca SRL, San Miguel de Tucuman, Tucuman

Centro de Investigaciones Medicas Tucuman, San Miguel de Tucuman, Tucuman

Investigaciones Clinicas Tucuman, San Miguel de Tucuman, Tucuman

Hospital Italiano de La Plata, Buenos Aires, Not set

Centro Privado de Medicina Familiar - Mind Out Research, Ciudad Autonoma Buenos Aires, Not set

Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires, Not set

Instituto de Reumatologia, Mendoza, Not set

CER San Juan Centro Polivalente de Asistencia e Inv. Clinica, San Juan, Not set

Clínica SER da Bahia, Salvador, Bahia

HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará, Fortaleza, Ceará

L2IP - Instituto de Pesquisas Clínicas Ltda., Brasilia, Distrito Federal

CEDOES - Diagnóstico e Pesquisa, Vitória, Espírito Santo

IPC MT Instituto de Pesquisas Clinicas do Mato Grosso, Santo Ângelo, Mato Grosso

Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte, Minas Gerais

CMiP - Centro Mineiro de Pesquisa, Juiz de Fora, Minas Gerais

Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A, Rio de Janeiro, Rio Do Janeiro

IDERJ - Instituto de Dermatologia e Estética do Brasil Ltda, Rio de Janeiro, Rio Do Janeiro

Hospital Bruno Born, Lajeado, Rio Grande Do Sul

Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Nucleo de Pesquisa Clinica do Rio Grande do Sul, Porto Alegre, Rio Grande Do Sul

LMK Serviços Médicos S/S Ltda, Porto Alegre, Rio Grande Do Sul

CEMEC - Centro Multidisciplinar de Estudos Clínicos, Sao Bernardo Do Campo, Sao Paulo

CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos, São Paulo, Sao Paulo

Medical center Medconsult Pleven OOD, Pleven, Not set

UMHAT 'Dr. Georgi Stranski', EAD, Pleven, Not set

DCC 1 - Ruse, EOOD, Ruse, Not set

DCC 'Alexandrovska', EOOD, Sofia, Not set

DCC Focus 5 - MEOH OOD, Sofia, Not set

Military Medical Academy - MHAT - Sofia, Sofia, Not set

Laser Rejuvenation Clinics, Inc., Calgary, Alberta

Laster Rejuvenation Clinics Edmonton D.T. Inc., Edmonton, Alberta

Dermatology Ottawa Research Centre, Ottawa, Ontario

Medicor Research Inc, Sudbury, Ontario

DIEX Recherche Sherbrooke Inc., Sherbrooke, Quebec

Centro Medico SkinMed, Las Condes, Not set

Dermacross, Santiago, Not set

BioMedica Research Group, Santiago, Not set

CeCim Biocinetic, Santiago, Not set

CIEC - Centro Internacional de Estudios Clínicos, Santiago, Not set

Clinical Research Chile SpA., Valdivia, Not set

Oncocentro APYS, Viña del Mar, Not set

Beijing Tongren Hospital, Capital Medical University, Beijing, Beijing

Peking Union Medical College Hospital, Beijing, Beijing

The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing

The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian

Dongguan People's Hospital, Dongguan, Guangdong

Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong

Shenzhen Second People's Hospital, Shenzhen, Guangdong

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangzhou

Nanyang First People's Hospital, Nanyang, Henan

Henan Provincial People's Hospital, Zhengzhou, Henan

The second Xiangya Hospital of Central South University, Changsha, Hunan

The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia

Hospital for Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu

Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu

The First Hospital of Jilin University, Changchun City, Jilin

Qilu Hospital of Shandong University, Jinan, Shandong

Ruijin Hospital of Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai

Zhongshan Hospital Fudan University, Shanghai, Shanghai

Shanghai Skin Disease Hospital, Shanghai, Shanghai

The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan

The First Affiliated Hospital of Zhejiang University school of medicine, Hangzhou, Zhejiang

Hangzhou First People's Hospital, Hangzhou, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang

Centro de Investigacion Medico Asistencial S.A.S, Barranquilla, Atlántico

Healthy Medical Center, Zipaquirá, Cundinamarca

Servimed S.A.S., Bucaramanga, Santander

Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM, Bogotá, Not set

CHU Nice - Hopital de l Archet, Nice cedex 3, Alpes Maritimes

Hôpital de la Timone, Marseille cedex 5, Bouches-du-Rhône

CHU de Caen - Hopital de la Cote de Nacre, Caen, Calvados

CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, Doubs

Hopital Larrey, Toulouse Cedex 9, Haute Garonne

Hôpital Privé d'Antony, Antony, Hauts De Seine

Hopital Saint Eloi, Montpellier Cedex 5, Herault

Hôpital Saint-Louis, Cedex 10, Paris

Hopital Edouard Herriot - CHU Lyon, Lyon, Rhone

Hopital Tenon, Paris, Not set

Universitaetsklinikum Heidelberg, Heidelberg, Baden Wuerttemberg

Universitaetsklinikum Erlangen, Erlangen, Bayern

Fachklinik Bad Bentheim Dermatologie, Bad Bentheim, Niedersachsen

Elbekliniken Buxtehude GmbH, Buxtehude, Niedersachsen

Klinikum Oldenburg AoeR, Oldenburg, Niedersachsen

Universitaetsklinikum Aachen AoeR, Aachen, Nordrhein Westfalen

Universitaetsklinikum Bonn AoeR, Bonn, Nordrhein Westfalen

Universitaetsklinikum Duesseldorf AoeR, Duesseldorf, Nordrhein Westfalen

Universitaetsklinikum Muenster, Muenster, Nordrhein Westfalen

Universitaetsklinikum Halle (Saale), Halle, Sachsen Anhalt

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden, Sachsen

Universitaetsklinikum Schleswig-Holstein - Campus Kiel, Kiel, Schleswig Holstein

Charité - Campus Charité Mitte, Berlin, Not set

Pecsi Tudomanyegyetem, Pecs, Not set

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS, Bologna, Not set

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia, Not set

Università degli studi di Firenze, Firenze, Not set

IRCCS Ospedale Policlinico San Martino, Genova, Not set

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Milano, Not set

Ospedale San Raffaele, Milano, Not set

Azienda Ospedaliera Universitaria Policlinico 'Federico II', Napoli, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Not set

JCHO Chukyo Hospital, Nagoya-shi, Aichi-Ken

NHO Nagoya Medical Center, Nagoya-shi, Aichi-Ken

Fujita Health University Hospital, Toyoake-shi, Aichi-Ken

Aomori Prefectural Central Hospital, Aomori-shi, Aomori-Ken

Juntendo University Urayasu Hospital, Urayasu-shi, Chiba-Ken

University of Fukui Hospital, Yoshida-gun, Fukui-Ken

Hospital of the University of Occupational and Environmental Health, Kitakyushu-shi, Fukuoka-Ken

Hokkaido University Hospital, Sapporo-shi, Hokkaido

Kakogawa Central City Hospital, Kakogawa-shi, Hyogo-Ken

Kita Harima Medical Center, Ono-shi, Hyogo-Ken

Kanazawa University Hospital, Kanazawa-shi, Ishikawa-Ken

St. Marianna University Hospital, Kawasaki-shi, Kanagawa-Ken

Yokohama City University Medical Center, Yokohama-shi, Kanagawa-Ken

Yokohama City University Hospital, Yokohama-shi, Kanagawa-Ken

NHO Yokohama Medical Center, Yokohama-shi, Kanagawa-Ken

Kumamoto University Hospital, Kumamoto-shi, Kumamoto-Ken

Tohoku University Hospital, Sendai-shi, Miyagi-Ken

Nagasaki University Hospital, Nagasaki-Shi, Nagasaki-Ken

Niigata University Medical & Dental Hospital, Niigata-shi, Niigata-Ken

Japanese Red Cross Okayama Hospital, Okayama-shi, Okayama-Ken

NHO Osaka Minami Medical Center, Kawachinagano-shi, Osaka-Fu

Daini Osaka Police Hospital, Osaka-shi, Osaka-Fu

Kindai University Hospital, Osakasayama-shi, Osaka-Fu

Osaka University Hospital, Suita-shi, Osaka-Fu

Takatsuki Red Cross Hospital, Takatsuki-shi, Osaka-Fu

Shiga University of Medical Science Hospital, Otsu-shi, Shiga-Ken

Shimane University Hospital, Izumo-shi, Shimane-Ken

Teikyo University Hospital, Itabashi-ku, Tokyo-To

Showa University East Hospital, Shinagawa-ku, Tokyo-To

Wakayama Medical University Hospital, Wakayama-shi, Wakayama-Ken

Korea University Ansan Hospital, Ansan-si, Gyeonggi-do

Ajou University Hospital, Suwon, Gyeonggi-do

Chonnam National University Hospital, Gwangju, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Hanyang University Seoul Hospital, Seoul, Not set

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set

Clinstile, S.A. de C.V., Ciudad de México, Distrito Federal

Centro de Investigacion Clínica GRAMEL S.C, Mexico, Distrito Federal

Centro de investigacion medica y reumatologia, Guadalajara, Jalisco

Consultorio Privado Dr. Miguel Cortes Hernandez, Cuernavaca, Morelos

Medical Care & Research SA de CV, Merida, Yucatán

Derma Norte del Bajio S.C., Aguascalientes, Not set

Investigacion y Biomedicina de Chihuahua, S.C., Chihuahua, Not set

Invest Clinicas Sac Inst de Ginecologia y Reproduccion, Lima, Not set

The Medical City Clark, Mabalacat, Pampanga

Cebu Doctors University Hospital, Cebu City, Not set

Mary Mediatrix Medical Center, Lipa City, Not set

Medical Center Manila, Manila, Not set

Philippine General Hospital, Manila, Not set

Jose R. Reyes Memorial Medical Center, Manila, Not set

Far Eastern University - Dr. Nicanor Reyes Medical Foundation, Quezon City, Metro Manila, Not set

St. Luke's Medical Center, Quezon City, Not set

Ilocos Training and Regional Medical Center, San Fenando, La Union, Not set

Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski, Krakow, Not set

SPZOZ Szpital Uniwersytecki w Krakowie, Kraków, Not set

Dermoklinika Centrum Medyczne SC M Kierstan J Narbutt A Lesiak, Lodz, Not set

Kliniczny Szpital Wojewodzki nr 1 im.F.Chopina, Rzeszow, Not set

Szpital Kliniczny Dzieciatka Jezus, Warszawa, Not set

Royalderm, Warszawa, Not set

Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska, Wroclaw, Not set

Centro Hospitalar e Universitário de Coimbra, E.P.E (HUC), Coimbra, Not set

Hospital de Egas Moniz, Lisboa, Not set

Hospital CUF Descobertas, Lisboa, Not set

Centro Hospitalar Universitártio do Porto, E.P.E., Porto, Not set

Unidade Local de Saúde do Alto Minho, E.P.E., Viana do Castelo, Not set

Dr. Samuel Sanchez PSC, Caguas, Not set

GCM Medical Group PSC - Hato Rey, San Juan, Not set

King Faisal Specialist Hospital & Research Center, Riyadh, Not set

King Saud University, Riyadh, Not set

Institute of Rheumatology, Belgrade, Not set

University Clinical Center of Serbia, Belgrade, Not set

Clinical Center of Vojvodina, Novi Sad, Not set

Artromac n.o., Kosice, Not set

Narodny ustav reumatickych chorob, Piestany, Not set

Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona

Hospital Universitario Rio Hortega, Valladolid, Cantabria

Hospital Universitario Fundacion Alcorcon, Alcorcón, Madrid

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid

Hospital del Mar, Barcelona, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Hospital Universitario Reina Sofia, Cordoba, Not set

Complejo Hospitalario Universitario A Coruña, La Coruña, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Karolinska Universitetssjukhuset - Solna, Stockholm, Not set

Universitaetsspital Zuerich, Zurich-Flughafen, Zurich

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Not set

Kantonsspital St. Gallen, St. Gallen, Not set

Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua, Not set

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set

Taichung Veterans General Hospital, Taichung, Not set

Taipei Veterans General Hospital, Taipei, Not set

Whipps Cross University Hospital, London, Greater London

Manchester Royal Infirmary, Manchester, Greater Manchester

Queen Elizabeth Hospital, Birmingham, West Midlands

Chapel Allerton Hospital, Leeds, West Yorkshire

Conditions: Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus

Learn More ›