Missouri is currently home to 1896 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Metabolic and Hemodynamic Reserve in Pediatric SCA
NCT04406818
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those without, reflecting a greater loss. The investigators will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and cons... Read More
Gender:
ALL
Ages:
Between 4 years and 21 years
Trial Updated:
01/14/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Child, Only, Brain Diseases, Sickle Cell Disease, Anemia, Sickle Cell
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Cerebral Oxygen Metabolism in Children
NCT04157179
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, su... Read More
Gender:
ALL
Ages:
Between 3 years and 50 years
Trial Updated:
01/14/2025
Locations: Washington University of St. Louis, Saint Louis, Missouri
Conditions: Sickle Cell Disease, Cerebral Stroke
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Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation
NCT02782546
Recruiting
This is a standard phase 2 study powered to demonstrate improvement in the 100 day leukemia free survival to 30% from \<10% expected with the use of reduced intensity haplo-HCT in this extremely high-risk patient cohort (based on the institutional experience using non-myeloablative / reduced intensity conditioning in a similar patient cohort). A formal safety evaluation will be done after every 6th patient enrolled and the trial will be stopped if noted to have unusually higher engraftment fail... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Acute Myeloid Leukemia
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Maternal Maneuvers During Prolonged Labor
NCT06636149
Recruiting
This pilot, randomized control trial will test whether or not a specific circuit of position changes improves maternal outcomes in cases of prolonged labor. Patient who have prolonged labor will be approached for consent and randomization to one of two study groups: circuit intervention against routine standard of care position changes. 82 patients will be enrolled in the study. Exclusion criteria will include: any uterine infection prior to randomization, magnesium sulfate treatment, major fet... Read More
Gender:
FEMALE
Ages:
12 years and above
Trial Updated:
01/13/2025
Locations: Washington University Medicine, Saint Loius, Missouri
Conditions: Labor Stage, First, Prolonged Labor
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Prospective Clinical Assessment Study in Children with Hypochondroplasia
NCT06410976
Recruiting
This is a long-term, multicenter, non-interventional study of children ages 2.5 to \<17 years with hypochondroplasia (HCH).
Gender:
ALL
Ages:
Between 30 months and 16 years
Trial Updated:
01/13/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Hypochondroplasia
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Polatuzumab Vedotin (Pola) Plus Rituximab (R) in Patients With Post-transplant Lymphoproliferative Disorder (PTLD)
NCT06040320
Recruiting
This study will test polatuzumab vedotin in combination with rituximab in patients with treatment-naïve CD20-positive post-transplant lymphoproliferative disorder (PTLD) based on the established efficacy of polatuzumab vedotin in B-cell lymphomas and the inadequate response rate of PTLD to single-agent rituximab. The hypothesis is that this combination therapy will be safe, well-tolerated, and effective. If so, patients with PTLD will be able to be spared the toxicity of anthracycline-based chem... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Post-transplant Lymphoproliferative Disorder
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Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine
NCT05738213
Recruiting
The purpose of this research study is to investigate the relationships between sex hormone levels and experimental pain sensitivity and migraine severity will be examined.
Gender:
ALL
Ages:
Between 11 years and 15 years
Trial Updated:
01/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Migraine
Register for Updates
A Radiotracer ([18F]FluorThanatrace) by PET/CT for the Imaging of Breast Cancer
NCT05226663
Recruiting
This phase II trial tests whether \[18F\]FluorThanatrace by positron emission tomography (PET)/computed tomography (CT) can improve imaging techniques in patients with breast cancer undergoing a standard of care biopsy or surgery. \[18F\]FluorThanatrace is a new radioactive tracer, which is a type of imaging agent that is labeled with a radioactive tag and injected into the body to help with imaging scans. PET is an established imaging technique that utilizes small amounts of radioactivity attac... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Siteman Cancer Center at Washington University, Saint Louis, Missouri
Conditions: Breast Carcinoma
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Spine Procedures Assisted with RoboTics and Navigation
NCT05071144
Recruiting
Creation of a pediatric robotic spine surgery registry will allow for data collection and analysis on the coupled use of robotics and navigation, as well as patient-specific rods in pediatric spine deformity surgery across participating study institutions. Eventually, an educational and informative framework for this technology will be established.
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
01/13/2025
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: Spine Deformity, Idiopathic Scoliosis, Adolescent Idiopathic Scoliosis, Spondylolisthesis, Congenital Scoliosis, Neuromuscular Scoliosis
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Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM
NCT06081894
Recruiting
This clinical trial will study the effects of aficamten (versus placebo) on the quality of life, exercise capacity, and clinical outcomes of patients with non-obstructive hypertrophic cardiomyopathy.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/11/2025
Locations: Saint Luke's Hospital of Kansas City, Kansas City, Missouri
Conditions: Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
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Auricular VNS Following Subarachnoid Hemorrhage
NCT04557618
Recruiting
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following spontaneous subarachnoid hemorrhage.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/11/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Subarachnoid Hemorrhage
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A Phase 1/2 Study of BHV-1510 (Previously PBI-410) in Advanced Solid Tumors
NCT06384807
Recruiting
This is a Phase 1/2, first in human (FIH), open-label, multicenter study of BHV-1510 monotherapy and in Combination with Cemiplimab in participants with previously treated, advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/10/2025
Locations: Washington University School of Med, Saint Louis, Missouri
Conditions: Solid Tumor
Register for Updates