The state of Missouri currently has 32 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Saint Louis, Kansas City, St. Louis and Springfield.
Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response
Recruiting
VETERANS ONLY. Chronic low back pain (cLBP) is common. Most Americans will have at least one episode of low back pain in their lifetimes. Approximately 50% of all US Veterans have chronic pain, and CLBP is the most common type of pain in this population. This study will use a sequential randomized, pragmatic, 2-step comparative effectiveness study design. The main goal is to identify the best approach for treating cLBP using commonly recommended non-surgical and non-pharmacological options. The... Read More
Gender:
All
Ages:
All
Trial Updated:
03/21/2024
Locations: St. Louis VA Medical Center John Cochran Division, St. Louis, MO, Saint Louis, Missouri
Conditions: Chronic Low Back Pain
Sleep and Pain Interventions in Women With Fibromyalgia
Recruiting
Insomnia affects 67-88% of chronic pain patients. SPIN II is a randomized controlled clinical trial that will compare the effects of two cognitive behavioral sleep treatments in women with fibromyalgia and insomnia. This trial will yield important information about the roles of sleep, arousal, and brain structure and function in the development and maintenance of chronic pain in women with fibromyalgia.
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: University of Missouri- Department of Psychiatry, Columbia, Missouri
Conditions: Fibromyalgia, Insomnia, Chronic Widespread Pain
Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
Recruiting
The aim of this study is to assess whether IW-3300 is safe and works for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). The main question the study aims to answer is whether IW-3300 helps bladder pain and other symptoms (for example, bladder burning, pressure and discomfort). Subjects will be assigned to receive either the study drug or placebo by chance.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
03/08/2024
Locations: Specialty Clinical Research of St. Louis-Objective Health, Saint Louis, Missouri
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
Patient Retrospective Outcomes (PRO)
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Saint Louis Pain Consultants, Chesterfield, Missouri +1 locations
Conditions: Chronic Pain
RELIEF - A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use - and - To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Midwest Pain Center, Chesterfield, Missouri +2 locations
Conditions: Pain
Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)
Recruiting
The purpose of the study is to evaluate the efficacy and safety of VX-548 in treating participants with PLSR.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
03/06/2024
Locations: St. Louis Pain Consultants, Chesterfield, Missouri +1 locations
Conditions: Painful Lumbosacral Radiculopathy
iFuse TORQ for the Treatment of Sacroiliac Joint Dysfunction
Recruiting
STACI is a prospective, multicenter, study of SIJ fusion using the iFuse TORQ implant system.
Gender:
All
Ages:
21 years and above
Trial Updated:
03/05/2024
Locations: St Louis Pain Consultants, Chesterfield, Missouri
Conditions: Sacroiliac Joint Dysfunction, Sacroiliac; Fusion, Sacroiliac Disorder, Sacroiliac Joint Pain
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Recruiting
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: StudyMetrix Research, Saint Peters, Missouri +1 locations
Conditions: Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: StudyMetrix Research, Saint Peters, Missouri +1 locations
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)
Recruiting
Evaluation of the efficacy of LX9211 compared to placebo in reducing DPNP.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Lexicon Investigational Site (104), Hazelwood, Missouri
Conditions: Diabetic Peripheral Neuropathic Pain
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Recruiting
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when comp... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/12/2024
Locations: Washington University in Saint Louis, Saint Louis, Missouri
Conditions: Surgery, Pain, Postoperative
Multi-modal Imaging of Myofascial Pain
Recruiting
The goal of this study is to develop new imaging biomarkers for quantitative assessments of myofascial pain.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/08/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Myofascial Pain