Missouri is currently home to 1892 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation
NCT02782546
Recruiting
This is a standard phase 2 study powered to demonstrate improvement in the 100 day leukemia free survival to 30% from \<10% expected with the use of reduced intensity haplo-HCT in this extremely high-risk patient cohort (based on the institutional experience using non-myeloablative / reduced intensity conditioning in a similar patient cohort). A formal safety evaluation will be done after every 6th patient enrolled and the trial will be stopped if noted to have unusually higher engraftment fail... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Acute Myeloid Leukemia
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Maternal Maneuvers During Prolonged Labor
NCT06636149
Recruiting
This pilot, randomized control trial will test whether or not a specific circuit of position changes improves maternal outcomes in cases of prolonged labor. Patient who have prolonged labor will be approached for consent and randomization to one of two study groups: circuit intervention against routine standard of care position changes. 82 patients will be enrolled in the study. Exclusion criteria will include: any uterine infection prior to randomization, magnesium sulfate treatment, major fet... Read More
Gender:
FEMALE
Ages:
12 years and above
Trial Updated:
01/13/2025
Locations: Washington University Medicine, Saint Loius, Missouri
Conditions: Labor Stage, First, Prolonged Labor
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Polatuzumab Vedotin (Pola) Plus Rituximab (R) in Patients With Post-transplant Lymphoproliferative Disorder (PTLD)
NCT06040320
Recruiting
This study will test polatuzumab vedotin in combination with rituximab in patients with treatment-naïve CD20-positive post-transplant lymphoproliferative disorder (PTLD) based on the established efficacy of polatuzumab vedotin in B-cell lymphomas and the inadequate response rate of PTLD to single-agent rituximab. The hypothesis is that this combination therapy will be safe, well-tolerated, and effective. If so, patients with PTLD will be able to be spared the toxicity of anthracycline-based chem... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Post-transplant Lymphoproliferative Disorder
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Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine
NCT05738213
Recruiting
The purpose of this research study is to investigate the relationships between sex hormone levels and experimental pain sensitivity and migraine severity will be examined.
Gender:
ALL
Ages:
Between 11 years and 15 years
Trial Updated:
01/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Migraine
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Spine Procedures Assisted with RoboTics and Navigation
NCT05071144
Recruiting
Creation of a pediatric robotic spine surgery registry will allow for data collection and analysis on the coupled use of robotics and navigation, as well as patient-specific rods in pediatric spine deformity surgery across participating study institutions. Eventually, an educational and informative framework for this technology will be established.
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
01/13/2025
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: Spine Deformity, Idiopathic Scoliosis, Adolescent Idiopathic Scoliosis, Spondylolisthesis, Congenital Scoliosis, Neuromuscular Scoliosis
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Auricular VNS Following Subarachnoid Hemorrhage
NCT04557618
Recruiting
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following spontaneous subarachnoid hemorrhage.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/11/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Subarachnoid Hemorrhage
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Sex Hormones, Postoperative Pain and Opioid Use
NCT06023225
Recruiting
Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use. Aim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors
Gender:
FEMALE
Ages:
Between 11 years and 16 years
Trial Updated:
01/10/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Postoperative Pain, Opioid Use
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Examining Racial and Socioeconomic Differences in Chronic Low Back Pain
NCT05991440
Recruiting
The purpose of this research study is to gain a better understanding of how people's racial background and socioeconomic status (e.g., income, education, and employment) impact their experiences of chronic low back pain (cLBP).
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/10/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Chronic Pain
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Preconception Intervention for Incarcerated Women With Substance Use
NCT05854836
Recruiting
The goal of this pilot trial is to test the feasibility and acceptability as well as efficacy of the adapted intervention, CHOICES-PLEAS (Pregnancy Liberated from Exposure to Alcohol and Substances) among women will illicit polysubstance use participating in a court-mandated jail-based 90-day substance use disorder treatment program. The main questions it aims to answer are: 1. What is the feasibility and acceptability of implementing the CHOICES-PLEAS intervention in a court-mandated jail-base... Read More
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
01/10/2025
Locations: Buzz Westfall Justice Center, Saint Louis, Missouri
Conditions: Substance Use Disorders
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Withdrawal of Tiratricol Treatment in Males with Monocarboxylate Transporter 8 Deficiency (MCT8 Deficiency)
NCT05579327
Recruiting
This is a double-blind, randomized phase 3 multicenter placebo-controlled study in at least 16 evaluable male participants diagnosed with MCT8 deficiency. Male participants, from 4 years of age (at randomization) and having demonstrated stable maintenance treatment with tiratricol, will be randomized to receive placebo or tiratricol for 30 days or until reaching rescue criterion (serum total triiodothyronine \[T3\] \> upper limit of normal \[ULN\] of the participant's normal range, for a sample... Read More
Gender:
MALE
Ages:
4 years and above
Trial Updated:
01/10/2025
Locations: SSM Health Cardinal Glennon Children's Hospital, Saint Louis, Missouri
Conditions: Monocarboxylate Transporter 8 Deficiency, Allan-Herndon-Dudley Syndrome
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Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, the ERASur Study
NCT05673148
Recruiting
This phase III trial compares total ablative therapy and usual systemic therapy to usual systemic therapy alone in treating patients with colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for patients who are not participating in a study is treatment with intravenous (IV) (through a vein) and/or oral medications (systemic therapy) to help stop the cancer sites from getting larger and the spread of the cancer to additional body sites. Ablative means... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Mercy Hospital Saint Louis, Saint Louis, Missouri
Conditions: Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
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BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
NCT05456880
Recruiting
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/09/2025
Locations: Washington University School of Medicine in St. Louis, Saint Louis, Missouri
Conditions: Sickle Cell Disease
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