Missouri is currently home to 1899 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Health Outcomes of Parents With Cystic Fibrosis-Aim 2
NCT06296394
Recruiting
The goal of this observational prospective study is to determine the health impact of parenthood on United States (US) people with CF in the era of CF transmembrane regulator protein (CFTR) modulators. The investigators will collect physical and mental health data to comprehensively evaluate the impact of parenthood in CF with widespread highly effective CFTR modulator use. The main hypotheses this study aims to examine are: H1: Parents with CF and moderate-to-severe depression have more rapid... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Cystic Fibrosis, Parenthood Status
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Propranolol in Primary Progressive Aphasia
NCT06066710
Recruiting
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/24/2025
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Aphasia, Primary Progressive
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Wheelchair User Physical Activity Training Intervention to Enhance Cardiometabolic Health
NCT06013046
Recruiting
The goal of the study is to improve cardiometabolic health outcomes for wheelchair users and identify strategies for achieving sufficient physical activity intensity during bouts of structured physical activity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Physical Disability
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Suubi-Mhealth: A Mobile Health Intervention to Address Depression Among Youth
NCT05965245
Recruiting
The overall goal of this study is to develop an mHealth intervention (Suubi-Mhealth) for use among Ugandan youth (14-17 years) with comorbid HIV and depression, taking into account their unique contextual, cultural, and developmental needs. This digital therapy intervention delivered via a mobile application, will utilize the core tenets of cognitive-behavioral therapy (CBT) found to improve depression and ART adherence.
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
03/24/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Depression, HIV Infection
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Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA
NCT05855083
Recruiting
The purpose of this study is to evaluate the safety and efficacy of narsoplimab in pediatric patients with thrombotic microangiopathies (TMA) following hematopoietic stem cell transplant (HSCT).
Gender:
ALL
Ages:
Between 28 days and 17 years
Trial Updated:
03/24/2025
Locations: Omeros Investigational Site, Saint Louis, Missouri
Conditions: Thrombotic Microangiopathies, Hematopoietic Stem Cell Transplantation
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Spinal Cord Stimulation and Training
NCT05472584
Recruiting
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
03/24/2025
Locations: Washington University, Saint Louis, Missouri
Conditions: Spinal Cord Injuries
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A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
NCT05440708
Recruiting
The primary objectives of Cohort A Phase 1b are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent to participants with locally advanced or metastatic, and unresectable Hepatocellular Carcinoma (HCC) and to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of TTI-101 as a single agent. The primary objectives of Cohort A Phase 2 are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent at the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Hepatocellular Carcinoma
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Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
NCT05256069
Recruiting
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
03/24/2025
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Vasodilation, Hypoxia
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Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers
NCT04632628
Recruiting
Over the next 30 years, more than 10 million persons living with dementia in the United States will receive care at home from an unpaid and untrained family caregiver. At home care is preferred by caregivers and persons with dementia alike, but increases the caregiver's risk of insomnia and related negative health outcomes, including depression, anxiety, cognitive disturbances and poor quality of life. Cognitive behavioral therapy for insomnia (CBT-I) is a highly effective and established eviden... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Insomnia Chronic, Dementia
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Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy
NCT03424850
Recruiting
The purpose of this research study is to learn more about the outcomes and early and late side effects of treating early stage prostate cancer with high dose rate brachytherapy.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Prostate Cancer, Prostate Neoplasm
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Investigations of Dementia in Parkinson Disease
NCT02763683
Recruiting
The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/24/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Parkinsons
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Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control
NCT06890676
Recruiting
The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : * improved dental health * reduced risk of pneumonia * better glucose control for diabetic patients compared to the pre-project dental and general health evaluations of residents and the pre-project facility incidence of pneumonia. Dental infection control treatment includes treating gum infections, stopping or slowing decay with f... Read More
Gender:
ALL
Ages:
Between 60 years and 100 years
Trial Updated:
03/21/2025
Locations: Office of Dental Health, Department of Health and Senior Services, Jefferson City, Missouri
Conditions: Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections, Oral Infections, Periapical Infections, Pneumonia, Diabetes
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