Missouri is currently home to 1896 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Naltrexone Neuroimaging in Teens with Eating Disorders
NCT05509257
Recruiting
Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders. The hypothesis is that fMRI will be able to detect acute reward pathway modulation by naltrexone (an opioid antagonist) in pre-defined regions of interest (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex).
Gender:
ALL
Ages:
Between 13 years and 21 years
Trial Updated:
11/01/2024
Locations: Children's Mercy Research Institute, Kansas City, Missouri
Conditions: Eating Disorders, Binge Eating, Purging (Eating Disorders), Bulimia Nervosa, Anorexia Nervosa, Atypical
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Duvelisib Following Chimeric Antigen Receptor T-Cell Therapy
NCT05044039
Recruiting
While chimeric antigen receptor T-cell (CAR T-cell) therapy produces impressive response rates in heavily pre-treated patients, early loss of response remains a barrier. One potential mechanism of relapse is limited CAR T-cell persistence. Pre-clinical research shows that PI3K inhibition represents an intriguing mechanism for increasing CAR T-cell persistence that is easily reversible and CAR T-cell agnostic. The investigators hypothesize that PI3K inhibition with duvelisib would be safe, may pr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Non-hodgkin Lymphoma, Acute Lymphocytic Leukemia
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Pulse Oximetry Performance Comparison in Newborns
NCT06637917
Recruiting
The overall purpose is to directly compare pulse rate (PR) acquisition and oxygen saturation performance between two pulse oximeters (PO) in newborns.
Gender:
ALL
Ages:
29 weeks and above
Trial Updated:
10/31/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Newborn, Birth, Preterm
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Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
NCT05850689
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled parallel-group, fixed-dose study in patients with a primary diagnosis of MDD according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) who have an inadequate response to ongoing ADT.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/30/2024
Locations: Clinical Site, O'Fallon, Missouri
Conditions: Major Depressive Disorder
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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768
Recruiting
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be bette... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
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XTX301 in Patients with Advanced Solid Tumors
NCT05684965
Recruiting
This is a first-in-human, multicenter, Phase 1/2, open-label study designed to evaluate the safety and tolerability of XTX301 as monotherapy in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Advanced Solid Tumor
Register for Updates
NSAIDs Stent Study
NCT03638999
Recruiting
This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment, randomization, assessment procedures and implementation of the study intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Ureteral Stent Placement, Kidney Stone
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A Study to Evaluate the Efficacy and Safety of CBL-514 Compared to Placebo in Participants With Dercum's Disease Lipomas
NCT06303570
Recruiting
This is a single-blind, placebo-controlled, randomized phase 2 study to evaluate the efficacy and safety of CBL-514 injections in participants with Dercum\'s Disease lipomas.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
10/28/2024
Locations: Investigational Site 01, O'Fallon, Missouri
Conditions: Dercum's Disease
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Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials
NCT05108298
Recruiting
The purpose of this study is to evaluate feasibility and acceptability of completing PROs among AYAs randomized to Choice PRO vs Fixed PRO.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
10/28/2024
Locations: Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri
Conditions: Breast Cancer, NOS, CNS Primary Tumor, NOS, Cervical Cancer, NOS, Colorectal Cancer, NOS, Leukemia, NOS, Lymphoma, NOS, Miscellaneous Neoplasm, NOS, Non-Rhabdomyosarcoma Soft Tissue Sarcoma, NOS, Testicular Nonseminomatous Germ Cell Tumor, NOS, Thyroid Cancer, NOS, Melanoma, Bone Cancer, NOS
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Interventional Study Exploring the Occurrence of Surgical Site Infections.
NCT06661473
Recruiting
Interventional study exploring surgical site complication occurrences in high-risk revision patients undergoing TKA or THA using NPWT.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: St. Louis University, Saint Louis, Missouri
Conditions: Total Knee Arthroplasty, Total Hip Arthroplasty Revision, Total Knee Arthroplasty Revision
Register for Updates
Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study
NCT06289413
Recruiting
Observational two phase, retrospective and prospective registry study to assess the prevalence of and characterize outcomes of autonomic dysfunction (AD) in patients who undergo bariatric surgery (BS) and to better define the underlying pathophysiology of AD following BS.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/25/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: Autonomic Dysfunction, Orthostatic Intolerance
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Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
NCT06078735
Recruiting
The LockeT II study is a single center, prospective randomized study. It is intended to study the effectiveness of using LockeT device to gain hemostasis after venous procedures as compared to Manual Compression (MC). Approximately 110 patients will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: Atrial Fibrillation, Hemostasis
Register for Updates