Missouri is currently home to 1899 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
ALL
Ages:
Between 1 day and 6 months
Trial Updated:
01/17/2025
Locations: Washington University -- St. Louis, Saint Louis, Missouri
Conditions: Tuberous Sclerosis Complex, Epilepsy
Register for Updates
The Heart Outcomes in Pregnancy Expectations for Mom and Baby Study
NCT06517628
Recruiting
This is a prospective, observational study which is evaluating the obstetrical, neonatal, and cardiovascular outcomes of 1000 pregnant people with known heart disease to define how best to structure cardio-obstetrics care to optimize outcomes.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Saint Luke's Hospital of Kansas City, Kansas City, Missouri
Conditions: Pregnancy Complications, Cardiovascular
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A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
NCT06346067
Recruiting
Stage 1: To select the optimal dose of naporafenib + trametinib to be studied in Stage 2. Stage 2: To compare progression free survival (PFS) and overall survival (OS) for patients with NRAS-mutant (NRASm) melanoma who are randomized to receive the combination of naporafenib + trametinib to that of patients who are randomized to physician's choice of therapy (dacarbazine, temozolomide, or trametinib monotherapy).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/16/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Advanced or Metastatic NRAS-mutant Melanoma
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Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma
NCT05743595
Recruiting
This is a single institution, open-label, multi-arm, phase I study assessing the safety and immunogenicity of a personalized neoantigen-based personalized DNA vaccine combined with PD-1 blockade therapy in subjects with newly diagnosed, MGMT promoter unmethylated glioblastoma (GBM). Immune checkpoint blockade, specifically those targeting the PD-1/PD-L1 pathways, has shown efficacy in multiple solid and hematologic malignancies. Furthermore, as has been demonstrated in metastatic melanoma, comb... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Unmethylated Glioblastoma
Register for Updates
The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers
NCT05555069
Recruiting
This study will compare the efficacy of menthol-flavored versus tobacco-flavored 4th generation nicotine salt-based pod-system e-cigarettes in facilitating a switch from combustible cigarettes to e-cigarettes in adult menthol smokers.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/16/2025
Locations: University of Kansas Medical Center, Kansas City, Missouri
Conditions: Smoking Reduction
Register for Updates
ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03)
NCT04829604
Recruiting
A Global, Phase 2 Study of ARX788 in HER2-positive Metastatic Breast Cancer Patients who were previously treated with T-DXd
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Research Site, Bolivar, Missouri
Conditions: HER2 Positive Metastatic Breast Cancer
Register for Updates
DORAYA-HF Early Feasibility Study
NCT05206422
Recruiting
The study objective is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints, in ADHF patients deemed to have insufficient diuretic response.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Christian Hospital, Saint Louis, Missouri
Conditions: Acute Decompensated Heart Failure
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CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer
NCT05187182
Recruiting
This is a phase I trial of CA-4948 in combination with FOLFOX/PD-1 inhibitor with or without trastuzumab for unresectable gastric, GEJ, and esophageal cancer. During the Dose Escalation portion of the study, different dose levels of CA-4948 in combination with FOLFOX/nivolumab will be evaluated by BOIN algorithm. Dose Expansion will include Cohorts A and B. Expansion Cohort A will enroll up to 12 patients with HER2 negative gastric, GEJ, and esophageal cancer at the expansion dose of CA-4948 de... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Gastric Cancer, Esophageal Cancer, Stomach Cancer, Esophagus Cancer, Gastroesophageal Junction Cancer
Register for Updates
FSL2 Post Approval Study for Pediatric and Young Adults Patients
NCT04959552
Recruiting
This is a prospective, multi-center, non-randomized, single-arm study intended to characterize the safety of the FreeStyle Libre 2 Flash Glucose Monitoring System when used to manage diabetes in pediatric and young adult patient populations.
Gender:
ALL
Ages:
Between 4 years and 30 years
Trial Updated:
01/14/2025
Locations: The Children's Mercy Hospital, Kansas City, Missouri
Conditions: Diabete Mellitus
Register for Updates
Sleep Trial to Prevent Alzheimer's Disease
NCT04629547
Recruiting
The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
01/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Sleep, Alzheimer Disease
Register for Updates
Metabolic and Hemodynamic Reserve in Pediatric SCA
NCT04406818
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those without, reflecting a greater loss. The investigators will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and cons... Read More
Gender:
ALL
Ages:
Between 4 years and 21 years
Trial Updated:
01/14/2025
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Child, Only, Brain Diseases, Sickle Cell Disease, Anemia, Sickle Cell
Register for Updates
Cerebral Oxygen Metabolism in Children
NCT04157179
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, su... Read More
Gender:
ALL
Ages:
Between 3 years and 50 years
Trial Updated:
01/14/2025
Locations: Washington University of St. Louis, Saint Louis, Missouri
Conditions: Sickle Cell Disease, Cerebral Stroke
Register for Updates