Missouri is currently home to 1899 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MAP for Coaches: Translating Sports Injury Prevention Knowledge to Youth Sport Coaches
NCT05718063
Recruiting
The goal of this clinical trial is to test the effectiveness of the MAP for Coaches, a web-based Musculoskeletal Athletic injury Prevention training course, in youth sport coaches. The main question it aims to answer are: * Is the MAP for Coaches effective in increasing coaches' sport-specific knowledge of musculoskeletal injuries (types, incidence, risk factors, mechanisms, and best prevention practices, with focus on neuromuscular training warm-up exercise programs)? * Is the MAP for Coaches... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Olu Owoeye, Saint Louis, Missouri
Conditions: Knowledge, Attitudes, Practice
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Consent for Use of Stored Patient Specimens for Future Testing
NCT00031408
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Washington Univ / St Louis Connect Care, Saint Louis, Missouri
Conditions: HIV Infections
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To Assess the Safety and Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma
NCT06344052
Recruiting
The goal of this clinical trial is to evaluate the efficacy of using SP-002 in participants with locally advanced Basal cell carcinoma. The main question it aims to answer is what the objective response rate for a basal cell carcinoma tumor is following 1 or 3 cycles of SP-002 treatment given as an add-on to hedgehog pathway inhibitor therapy. Researchers will compare the objective response rate for treated Basal cell carcinoma tumors between 3 treatment Arms. * Arm 1 participants will receive... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Research Site, Lee's Summit, Missouri
Conditions: Basal Cell Carcinoma
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Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?
NCT05287841
Recruiting
The objective of this study is to compare the effectiveness of batten grafts plus septoplasty and turbinate reduction (intervention arm) compared to septoplasty and turbinate reduction alone (control arm), both in terms of subjective and objective assessments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Poplar Bluff Regional Medical Center, Poplar Bluff, Missouri
Conditions: Nasal Obstruction, Septal Defect, Allergic Rhinitis, Nasal Polyps, Nasal Valve Collapse
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Neuroblastoma Maintenance Therapy Trial
NCT02679144
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg/m2 ± 250 mg/m2 BID (strata 1, 2, 3, and 4) OR 2500 mg/m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
09/18/2024
Locations: Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Conditions: Neuroblastoma
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Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
NCT05975671
Recruiting
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when va... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/17/2024
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy, Sepsis, Severe, Septic Shock, Septic Syndrome
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ZIP Study-OL Study of Safety, PK, Efficacy, PD, Immunogenicity of ATB200/AT2221 in Pediatrics Aged 0 to < 18 y.o. w/LOPD
NCT03911505
Recruiting
This is a Phase 3, open-label, multicenter study to evaluate the safety, PK, efficacy, PD, and immunogenicity of Cipaglucosidase Alfa/Miglustat treatment in enzyme replacement therapy (ERT)-experienced and ERT-naïve pediatric subjects with Pompe disease, aged 0 to \< 18 years
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
09/16/2024
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: Pompe Disease (Late-onset)
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A Phase 2 Open Label Study of BA3021 in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
NCT05271604
Recruiting
This is a multi-center, open-label Phase 2 study designed to evaluate the efficacy and safety of BA3021 as monotherapy and combination therapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: Washington University Medical Siteman Cancer Center, Saint Louis, Missouri
Conditions: Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck, Recurrent Squamous Cell Carcinoma of the Head and Neck, Metastatic Cancer, Metastatic Squamous Cell Carcinoma of the Head and Neck
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Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery
NCT05954676
Recruiting
This phase of the project will evaluate the utility and efficacy of a personalized online patient education platform developed from efforts in Phase 1 in 1) increasing patients' and caregivers' pre- and post-operative preparedness and satisfaction, and 2) reducing readmission, ED/Urgent care/unplanned clinic visits and telephone calls to clinic staff.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Head and Neck Cancer, Head and Neck Neoplasms
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RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy
NCT03524430
Recruiting
The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Siteman Cancer Center, Saint Louis, Missouri
Conditions: Breast Neoplasm Female
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Baker Gordon Syndrome Natural History Study
NCT06399952
Recruiting
The goal of this study is to conduct a prospective, longitudinal assessment of the natural clinical progression of children and adults with Synaptotagmin1-Associated Neurodevelopmental Disorder also known as Baker Gordon Syndrome (BAGOS). This will be performed by acquiring baseline measurements and developing effective outcome measures and diagnostic tools for the disorder, to prepare the healthcare system for future clinical trials.
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
09/06/2024
Locations: University of Missouri Columbia, Columbia, Missouri
Conditions: Rare Diseases, Autism or Autistic Traits, Development Delay, SYT-SSX Fusion Protein Expression, Sleep Disorder, Epilepsy, Generalized, Motor Delay
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Compassionate Use of Domperidone for Refractory Gastroparesis
NCT04699591
Recruiting
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard treatments for their condition.
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
09/05/2024
Locations: Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Conditions: GERD, Gastroesophageal Reflux, Gastroparesis
Register for Updates