Missouri is currently home to 1899 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children
NCT04509050
Recruiting
This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children with cystic fibrosis (CF).
Gender:
ALL
Ages:
10 years and below
Trial Updated:
08/08/2024
Locations: Children's Mercy Kansas City, Kansas City, Missouri
Conditions: Cystic Fibrosis
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Ovarian Morphology in Girls
NCT04424576
Recruiting
Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predi... Read More
Gender:
FEMALE
Ages:
Between 9 years and 17 years
Trial Updated:
08/08/2024
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Amenorrhea, Oligomenorrhea, Puberty
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ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: BVL Clinical Research, Liberty, Missouri
Conditions: Ulcerative Colitis
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Smoking Cessation Behavioral Treatment Study
NCT03948893
Recruiting
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: University of Missouri - Columbia, Columbia, Missouri
Conditions: Tobacco Use Disorder
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Chromosome 9 P Minus Syndrome
NCT04586400
Recruiting
Patients with deletion of chromosome 9 P are rare (\~200 in the medical literature) and have a diverse set of phenotypic characteristics. We propose using state of the art genome sequencing methods to define the location and size of the deleted portion of chromosome 9 P as well as the genetic background in affected patients (whole genome sequencing) and correlate the genes in the deleted portion of chromosome 9 P with specific phenotypic characteristics of each patient. Enrolled participants wil... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/02/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Chromosome 9P Deletion Syndrome, 9p Minus Syndrome, Alfi Syndrome, 9P Monosomy, 9P Partial Monosomy Syndrome
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Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer
NCT03383094
Recruiting
The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: Washington University School of Medicine, Siteman Cancer Center, Saint Louis, Missouri
Conditions: Head and Neck Squamous Cell Carcinoma, Cancer, Cancer of Head and Neck, Cancer, Advanced, Cancer, Metastatic, Tumor, Tumor Recurrence, Tumor Neck, Tumor Metastasis, Oral Cancer, Oropharyngeal Cancer, Oropharynx Cancer, Oropharynx Cancer, Stage III, Oropharynx Cancer, Recurrent, Oropharynx Cancer, Metastatic
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Sensory Optimization of the Hospital Environment
NCT05230199
Recruiting
The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often applied in an inconsistent manner, reducing their benefit. Through a rigorous and scientific process, we have developed a structured multisensory intervention program, titled Supporting and Enhancing NICU Sensory Experiences (SENSE), which includes specific doses and ta... Read More
Gender:
ALL
Ages:
Between 1 day and 7 days
Trial Updated:
08/01/2024
Locations: Cardinal Glennon Children's Hospital, Saint Louis, Missouri
Conditions: Preterm, Parent-Child Relations, Parents, Development, Infant, Sensory Integration Dysfunction
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Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study
NCT02841553
Recruiting
In this study, the investigators hypothesize that studying monogenic variants with strong effect associated with severe insulin deficiency of Wolfram syndrome will provide important insights into the more complex type 1 and type 2 diabetes mellitus. Aim 1. Establish and maintain a registry of patients with Wolfram syndrome. An Internet based registry will be employed to enroll participants with the clinical diagnosis of Wolfram syndrome (insulin dependent DM and bilateral OA). Clinical informat... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
07/25/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Wolfram Syndrome, Diabetes Mellitus, Optic Nerve Atrophy, Deafness, Diabetes Insipidus, Ataxia
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Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics
NCT03348280
Recruiting
This trial will evaluate whether a particular type of circulating white blood cell, monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs. sufficiency will induce hormones that increase blood pressure.
Gender:
ALL
Ages:
Between 25 years and 80 years
Trial Updated:
07/23/2024
Locations: Barnes-Jewish & Washington University Diabetes Center, Saint Louis, Missouri
Conditions: Diabetes Mellitus, Type 2, Hypertension, Vitamin D Deficiency
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Intranasal Ketorolac Trial
NCT06083571
Recruiting
The purpose of this study is to determine if intranasal (IN) Ketorolac in combination with oral Prochlorperazine and Diphenhydramine is non-inferior to current migraine management which involves use of intravenous (IV) Ketorolac and oral adjuncts Prochlorperazine and diphenhydramine for reducing pain intensity in children with migraine headaches. The investigators hypothesize that IN ketorolac combined with these oral adjuncts is non-inferior to IV ketorolac and oral adjuncts in reducing acute... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
07/22/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Headache, Migraine
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Symptom-driven ICS/LABA Therapy for Adolescent Patients With Asthma Non-adherent to Daily Maintenance Inhalers
NCT05689983
Recruiting
Inhaler nonadherence is a common problem that has been estimated to account for approximately 60% of all asthma-related hospitalizations. Unfortunately, prior interventions to improve inhaler nonadherence have shown a lack of long-term success. This study proposes to assess the problem of non-adherence using a D\&I research lens while testing a new inhaler approach to potentially ameliorate the detrimental consequences of maintenance inhaler nonadherence.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
07/22/2024
Locations: Washington University in St. Louis School of Medicine, Saint Louis, Missouri
Conditions: Asthma in Children, Nonadherence, Medication
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Symptom-driven ICS/LABA Therapy for Patients With Asthma Non-adherent to Daily Maintenance Inhalers
NCT05111262
Recruiting
Inhaler nonadherence is a common problem that has been estimated to account for approximately 60% of all asthma-related hospitalizations. Unfortunately, prior interventions to improve inhaler nonadherence have shown a lack of long-term success. This study proposes to assess the problem of non-adherence using a D\&I research lens while testing a new inhaler approach to potentially ameliorate the detrimental consequences of maintenance inhaler nonadherence.
Gender:
ALL
Ages:
Between 12 years and 75 years
Trial Updated:
07/22/2024
Locations: Washington University in St. Louis School of Medicine, Saint Louis, Missouri
Conditions: Asthma, Nonadherence, Medication
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