Missouri is currently home to 1929 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Huntington's Disease
COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients
Recruiting
This is a subject registry study of patients who undergo cryoablation for their breast cancer after being determined not to be surgical candidates. Data collected as part of this registry will be used to assess the safety of percutaneous ultrasound-guided cryoablation in this population as well as provide long-term follow-up of subjects who received cryoablation.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Breast Cancer, Cancer of the Breast
Biological Response to Platelet-rich Plasma and Corticosteroid Injections
Recruiting
The goal is to determine how two different injections, corticosteroid and platelet-rich plasma, are used to treat patients with knee osteoarthritis may affect a patient's pain and function. Secondarily, the investigators are also interested in knowing how the two types of injections that will be given may affect what happens in the joint cartilage. The participants will receive one of the two injection types at the initial visit. There will be surveys to complete (around 10 questions) about the... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
02/23/2024
Locations: University of Missouri, Columbia, Missouri
Conditions: Knee Osteoarthritis
Continuous Versus Intermittent cARdiac Electrical moNitorinG
Recruiting
The purpose of this study is to validate the continuous patch monitoring system to evaluate cardiac arrhythmias in patients receiving drugs that can cause cardiac complications and compare the continuous patch system with standard electrocardiograms (ECGs).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Torsades de Pointe Caused by Drug, Long QT Syndrome
Amivantamab in Adenoid Cystic Carcinoma
Recruiting
The purpose of the study is to determine if treatment with amivantamab will be efficacious in patients with recurrent and metastatic adenoid cystic carcinoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Washington University - School of Medicine in St. Louis, Saint Louis, Missouri
Conditions: Salivary Gland Cancer
The Purpose of This Trial is to Determine if Regorafenib Plus Durvalumab (MEDI4736) is Safe and Effective in Treatment of Chemo Refractory Advanced Biliary Tract Cancers
Recruiting
The purpose of this study is to measure how effective combining Durvalumab and Regorafenib will be for participants with advance stage biliary track carcinoma who have received one line of prior treatment
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: University of Kansas Cancer Center - North, Kansas City, Missouri
Conditions: Advanced Biliary Tract Cancer
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
Recruiting
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
02/21/2024
Locations: University of Missouri, Columbia, Missouri
Conditions: Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction, Obesity
Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
Recruiting
Cervical spine injuries (CSI) are serious, but rare events in children. Spinal precautions (rigid cervical collar and immobilization on a longboard) in the prehospital setting may be beneficial for children with CSI, but are poorly studied. In contrast, spinal precautions for pediatric trauma patients without CSI are common and may be associated with harm. Spinal precautions result in well-documented adverse physical and physiological sequelae. Of substantial concern is that the mere presence of... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
02/21/2024
Locations: Washington University School of Medicine in St. Louis, Saint Louis, Missouri
Conditions: Cervical Spine Injury
The Tether™ - Vertebral Body Tethering System Post Approval Study
Recruiting
This study is an opportunity to provide continued reasonable assurance of the safety and probable benefit of The Tether HUD. The study will collect long term safety and efficacy information from patients who have had their idiopathic scoliosis treated via anterior vertebral body tethering (AVBT) with The Tether.
Gender:
All
Ages:
All
Trial Updated:
02/21/2024
Locations: University of Missouri - Columbia, Columbia, Missouri
Conditions: Scoliosis Idiopathic
Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors
Recruiting
This study aims to determine the efficacy of daily sirolimus and celecoxib, with low dose etoposide alternating with cyclophosphamide for pediatric participants with relapsed or refractory tumors.
Gender:
All
Ages:
Between 12 months and 30 years
Trial Updated:
02/21/2024
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Cancer
Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration
Recruiting
This is a Phase 1, multicenter, open-label, single- and multi-dose, dose-escalating study of OLX10212 in patients with neovascular age-related macular degeneration (AMD). This study is composed of 2 parts: Part A and Part B. Part A is a single ascending dose study, and Part B is a multiple ascending dose study. The primary objective is to evaluate the safety and tolerability of single and multiple intravitreal injection(s) of OLX10212 in patients with neovascular AMD. The exploratory objectives... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
02/20/2024
Locations: The Retina Institute, Saint Louis, Missouri
Conditions: Neovascular Age-related Macular Degeneration
Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)
Recruiting
Patients with clonal cytopenia of undetermined significance (CCUS) and lower-risk myelodysplastic syndromes (MDS) have a life expectancy of 5 to 10 years. Mortality in these patients results from progression of disease to higher-risk MDS or acute myeloid leukemia (AML) and cardiovascular events. Currently there are no FDA-approved treatments with the potential to improve survival of patients with CCUS and lower-risk MDS. Statins are an appealing class of drugs to consider in this situation as pr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/20/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Clonal Cytopenia of Undetermined Significance, Myelodysplastic Syndromes