Missouri is currently home to 1896 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
CAN-Stim Compared to SNS in Treatment of Urinary Urgency Incontinence With Wireless Neuromodulation Technology
NCT02577302
Recruiting
This is a prospective, randomized, controlled, multi-center, study in which 150 evaluable subjects will be randomized 1:1 to receive either a Protect CAN-Stim or SNS InterStim® system. Subjects from both groups will immediately start with therapy. The primary endpoint is a ≥ 50% reduction in number of incontinence episodes associated with urgency at the 3-month visit, with additional measurements assessed at 14 days, 1, 6, 9 and 12-months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2023
Locations: St. Louis Pain Consultants, Saint Louis, Missouri
Conditions: Urinary Incontinence, Urge
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Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment
NCT06067607
Recruiting
The goal of this study is to learn about eye gaze technology's use as an assessment and intervention of visual skills and the impact on occupational performance in children with cortical/cerebral visual impairment. The main questions the study aims to answer are: * Does the use of eye gaze technology with graded visual activities improve visual abilities: * Does an improvement in visual abilities improve occupational performance? - What are the factors that correlate with improved visual abilit... Read More
Gender:
ALL
Ages:
Between 2 years and 10 years
Trial Updated:
10/02/2023
Locations: The Children's Center for the Visually Impaired, Kansas City, Missouri
Conditions: Cortical/Cerebral Visual Impairment, Cerebral Palsy
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Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Barnes Jewish Hospital at Washington University, Saint Louis, Missouri
Conditions: Abdominal Aortic Aneurysm
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OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
NCT03747458
Recruiting
This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo). For the PK sub-study, up to 14 subjec... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
09/22/2023
Locations: University of Missouri Medical Center, Columbia, Missouri
Conditions: Bilateral Nasal Polyposis
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A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation
NCT05485974
Recruiting
A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2023
Locations: Alliance for Multispecialty Research, LLC, Kansas City, Missouri
Conditions: Lung Cancer, Non Small Cell Lung Cancer, Colorectal Cancer, Cancer of Pancreas, Colon Cancer, Solid Tumor, Cancer
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Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients
NCT05586958
Recruiting
The aim of this 6-month randomized multi-regional double-blind parallel group placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/24/2023
Locations: HealthCare Research, Hazelwood, Missouri
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
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A Dose Finding Study to Treat Bone Tumor(s)
NCT06008483
Recruiting
To determine the Maximum Tolerated Dose (MTD) of CycloSam®, Samarium-153-DOTMP (Sm-153-DOTMP), a radiopharmaceutical that delivers radiation to the bone when injected, given as a tandemly administered pair of doses to subjects with one or more solid tumor(s) in the bone or metastatic solid tumors to the bone that are visible on bone scan.
Gender:
ALL
Ages:
Between 15 years and 75 years
Trial Updated:
08/18/2023
Locations: Clinical Trial Site, Columbia, Missouri
Conditions: Bone Cancer, Bone Tumor, Solid Tumor, Metastatic Cancer to the Bone, Metastatic Tumor to the Bone
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The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
NCT03631225
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Clinvest Research, LLC., Springfield, Missouri
Conditions: Rheumatoid Arthritis (RA)
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Total Shoulder Arthroplasty Multi-Center Registry
NCT03511586
Recruiting
The objective of the study is a multi-center prospective registry to collect clinical outcomes of anatomic and reverse total shoulder arthroplasty.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/27/2023
Locations: Not set, Columbia, Missouri
Conditions: Shoulder Arthroplasty
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A Safety and Pharmacokinetics Study of IDP-118 Lotion in Pediatric Participants With Plaque Psoriasis
NCT03988439
Recruiting
This study is to evaluate the safety, the systemic exposure, and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-118 lotion in pediatric participants with moderate to severe plaque psoriasis.
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
07/25/2023
Locations: Bausch Site 6, Saint Joseph, Missouri
Conditions: Psoriasis
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Depression and Driving
NCT05446805
Recruiting
This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/24/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Depression, Drive
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Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism
NCT05088798
Recruiting
The purpose of the study is to provide access to 18F-DOPA PET to patients at Washington University and assess the utility of 18F-DOPA PET/MRI as a preoperative tool to detect and localize focal lesions in the pancreas that are causing hyperinsulinism.
Gender:
ALL
Ages:
All
Trial Updated:
07/24/2023
Locations: Washington University, Saint Louis, Missouri
Conditions: Hyperinsulinism
Register for Updates