Missouri is currently home to 1889 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
NCT05636176
Recruiting
This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to u... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: St Louis Heart & Vascular, P.C., Saint Louis, Missouri
Conditions: Heart Failure
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Interhemispheric Connectivity and Compensation
NCT05207878
Recruiting
The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Peripheral Nerve Injury Upper Limb, Healthy
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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)
NCT05183035
Recruiting
A study to evaluate if the randomized addition of venetoclax to a chemotherapy backbone (fludarabine/cytarabine/gemtuzumab ozogamicin \[GO\]) improves survival of children/adolescents/young adults with acute myeloid leukemia (AML) in 1st relapse who are unable to receive additional anthracyclines, or in 2nd relapse.
Gender:
ALL
Ages:
Between 29 days and 21 years
Trial Updated:
07/15/2025
Locations: The Children's Mercy Hospital - Adele Hall Campus, Kansas City, Missouri
Conditions: Acute Myeloid Leukemia
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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
NCT05096481
Recruiting
This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) as well as recurrent medulloblastoma (MB). PEP-CMV is a vaccine mixture of a peptide referred to as Component A. Component A is a synthetic long peptide (SLP) of 26 amino acid residues from human pp65. The SLPs encode multiple potential class I, class II, a... Read More
Gender:
ALL
Ages:
Between 3 years and 39 years
Trial Updated:
07/15/2025
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Recurrent Medulloblastoma
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A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
NCT05018585
Recruiting
The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous beta cell function and influence glycemic parameters in adolescent and adults recently diagnosed with T1D carrying the HLA DR3-DQ2 haplotype.
Gender:
ALL
Ages:
Between 12 years and 28 years
Trial Updated:
07/15/2025
Locations: Washington University Diabetes Center at Barnes Jewish Hospital, St. Louis, Missouri
Conditions: Type 1 Diabetes Mellitus
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Diffusion Basis Spectrum Imaging of the Prostate
NCT04420702
Recruiting
Diffusion Basis Spectrum Imaging (DBSI) represents a potential leap forward in improving prostate cancer early detection: a non-invasive and accurate imaging test for clinically significant prostate cancer.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Prostate Cancer
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Trial of Ixazomib for Kaposi Sarcoma
NCT04305691
Recruiting
This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Washington University, Saint Louis, Missouri
Conditions: Kaposi Sarcoma, Skin
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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
NCT02418442
Recruiting
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
07/15/2025
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Rheumatic Joint Disease
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Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
NCT06978166
Recruiting
The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain. This app is designed to support people who have chronic pain and who also experience symptoms of depression and/or anxiety. This version of the app is not currently available to the public. Eligible participants will be asked to download and use the Wysa for Chronic Pain study app for several weeks, and to use it as they normally w... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
07/14/2025
Locations: Washington University in St. Louis School of Medicine, St. Louis, Missouri
Conditions: Chronic Pain, Depression, Anxiety
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Phase 2b Study of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria (CSU)
NCT06873516
Recruiting
This study will evaluate the efficacy and safety of different doses of EVO756 in adults with moderate to severe chronic spontaneous urticaria (CSU).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: DelRicht Research - Town Center Dermatology, Wildwood, Missouri
Conditions: Chronic Spontaneous Urticaria
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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome
NCT06872125
Recruiting
The purpose of the study is to evaluate the efficacy, safety, and tolerability of zorevunersen in Patients with Dravet syndrome.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
07/14/2025
Locations: Washington University in St. Louis School of Medicine, St. Louis, Missouri
Conditions: Dravet Syndrome
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Auricular VNS Following Intracerebral Hemorrhage
NCT06799390
Recruiting
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following intracerebral hemorrhage.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Intracerebral Hemorrhage
Register for Updates