Missouri is currently home to 1898 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Inflammation
NCT06812429
Recruiting
The research aims to understand how a specific type of medication called Sodium-glucose co-transporter 2 (SGLT2) inhibitors affect cardiorenal inflammation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Washington University, Saint Louis, Missouri
Conditions: Inflammation
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Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome
NCT06538181
Recruiting
VEXAS (vacuoles, E1 ubiqutin-activating enzyme, X-linked, autoinflammatory, somatic syndrome) is a recently described disorder with severe hematologic and rheumatologic manifestations caused by somatic variants in the ubiquitin- activating enzyme gene, UBA1, that is acquired in hematopoietic progenitor cells. Patients are often debilitated by autoinflammatory symptoms and there is currently no standard of care available. There is a clinically unmet need for better therapies in VEXAS Syndrome. Th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic Syndrome, VEXAS, Vexas Syndrome
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Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH2A Decentralized Trial
NCT06240754
Recruiting
Study researchers think that a drug called enasidenib may help people with clonal cytopenia of undetermined significance (CCUS) because the drug blocks the mutated IDH2 protein, which may improve blood cell counts. The purpose of this study is to find out whether enasidenib is a safe and effective treatment for CCUS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Clonal Cytopenia of Undetermined Significance, CCUS Clonal Cytopenia of Undetermined Significance
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Sing for Your Saunter Part 2 R33
NCT06115382
Recruiting
The goal of this clinical trial is to compare to rhythm-based walking interventions to enhance gait in people with Parkinson's disease. The main questions it aims to answer are: * How does rhythm-based training influence walking performance? * How does brain activity change following rhythm-based training? Participants will perform walking to music and walking while singing, and will train on the use of these rhythms for 12 weeks. The investigators will compare the effects of training with musi... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Parkinson Disease
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A Study to Evaluate INCA033989 Administered in Participants With Myeloproliferative Neoplasms
NCT06034002
Recruiting
This study is being conducted to evaluate the safety, tolerability, dose-limiting toxicity (DLT) and determine the maximum tolerated dose (MTD) and/or recommended dose(s) for expansion (RDE) of INCA033989 administered in participants with myeloproliferative neoplasms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Myeloproliferative Neoplasms
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Migraine in Adolescents
NCT05654012
Recruiting
Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset. Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset. Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.
Gender:
ALL
Ages:
Between 10 years and 13 years
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Migraine
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Pembrolizumab and Hypofractionated Radiation Therapy for the Treatment of Mucosal Melanoma
NCT04318717
Recruiting
This is an open-label, single center, one cohort, non-randomized, phase II study. The aim is to evaluate the efficacy and safety of the combination of hypofractionated radiotherapy (HRT) and pembrolizumab on local tumor control in mucosal melanoma patients. Treatment effect will be compared with historical radiation therapy-alone control data.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Mucosal Melanoma of the Head and Neck
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Registry of Pediatric Orthopedic Trauma and Health Outcomes in Skeletally Immature Children
NCT04207892
Recruiting
International registry to collect prospective treatment and outcomes data on specific, key non-pathological fractures in children with open physes. Data will be collected during follow-up visits according to standard of care at 3 to 8 weeks, 3, 6, 12 and 24 months
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/13/2025
Locations: University of Missouri Health Care, Columbia, Missouri
Conditions: Long Bone Fractures
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Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492
Recruiting
This study evaluates the how addition of the Nodify XL2 test result impacts the clinical management of newly identified solid lung nodules assessed as low to moderate risk of cancer.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/13/2025
Locations: The Washington University, Saint Louis, Missouri
Conditions: Nodule Solitary Pulmonary, Non-small Cell Carcinoma
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Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
NCT03516708
Recruiting
The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is performed to remove the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Rectal Cancer
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Periprosthetic Fracture Registry (PPFx)
NCT03378557
Recruiting
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: University of Missouri Health Care, Columbia, Missouri
Conditions: Periprosthetic Fractures, Periprosthetic Fracture Around Prosthetic Joint Implant
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Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
NCT06633016
Recruiting
The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who have had an inadequate response to their antidepressant. This is a double-blind, placebo-controlled, 2-arm, parallel-group, Phase 2 study, randomized 1:1 (ABX-002: placebo). The study will include the following stages: 1. Screening, Treatment, and Follow-Up ; approximately 35 days 2. 42-day Treatme... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/12/2025
Locations: Autobahn Site #127, Saint Charles, Missouri
Conditions: Major Depressive Disorder
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