There are currently 12 active clinical trials seeking participants for Aortic Stenosis research studies. The states with the highest number of trials for Aortic Stenosis participants are New York, California, Texas and Ohio.
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
NCT06780241
Recruiting
This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. We aim to use advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) to determine advanced CMR predictors of reverse remodeling following aortic valve surgery and develop sex-specific thresholds for risk. Infrastructure developed by this study will enable development of an innovative, s... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/13/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Aortic Regurgitation, Mitral Regurgitation, Aortic Stenosis
Register for Updates
Comparative Imaging Assessment of Valvular Heart Disease
NCT04126018
Recruiting
The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
12/19/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Valve Heart Disease, Aortic Stenosis, Aortic Regurgitation
Register for Updates
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
NCT06777368
Recruiting
The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).
Gender:
ALL
Ages:
Between 18 years and 105 years
Trial Updated:
08/15/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +47 locations
Conditions: Aortic Stenosis
Register for Updates
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
NCT04634240
Recruiting
Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise regarding the management of concomitant CAD in patients undergoing TAVR. Some centers perform routine revascularization with percutaneous coronary intervention (PCI) (either before or after TAVR), while... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/22/2025
Locations: Huntsville Heart Center, Huntsville, Alabama +71 locations
Conditions: Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
Register for Updates
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
NCT05646381
Recruiting
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
07/11/2025
Locations: Heart Center Research Llc, Huntsville, Alabama +113 locations
Conditions: Aortic Stenosis
Register for Updates
AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction
NCT06580158
Recruiting
Two recently developed artificial intelligence-enabled electrocardiogram (AI-ECG) models have been developed to detect aortic stenosis (AS) and diastolic dysfunction (DD). AI-ECG for AS has a sensitivity of 78% and specificity of 74%, and AI-ECG for DD has a sensitivity of 83% and specificity of 80%. However, these models have never been prospectively applied to diagnose AS or DD, which may be useful for patients and providers from a diagnostic and prognostic perspective and especially in settin... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
12/30/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Aortic Stenosis, Diastolic Dysfunction
Register for Updates
Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry
NCT06055751
Recruiting
The purpose of the Long term Evaluation of Cardiac Arrhythmias after Transcatheter Aortic Valve Implantation (LOCATE) Registry is to perform long-term ambulatory monitoring of patients with severe aortic stenosis who undergo trans-catheter aortic valve implantation (TAVI) and develop new onset conduction system abnormalities post-procedure that do not require urgent permanent pacemaker (PPM) implantation. The primary objectives of this study are to assess the incidence of late onset heart block... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: Research Medical Center Clinic, Kansas City, Missouri +1 locations
Conditions: Aortic Stenosis, Atrial Fibrillation New Onset, Heart Block
Register for Updates
Loss of Y Chromosome in Aortic Stenosis
NCT06595407
Recruiting
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y... Read More
Gender:
MALE
Ages:
40 years and above
Trial Updated:
09/10/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Aortic Stenosis
Register for Updates
PARTNER 3 Trial - Aortic Valve-in-Valve
NCT03003299
Recruiting
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.
Gender:
ALL
Ages:
All
Trial Updated:
05/08/2024
Locations: Banner University Medical Center, Phoenix, Arizona +50 locations
Conditions: Aortic Stenosis, Aortic Stenosis, Severe
Register for Updates
Evaluating Infrasonic Hemodynography
NCT04636892
Recruiting
This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.
Gender:
ALL
Ages:
All
Trial Updated:
04/15/2024
Locations: Scripps Health, La Jolla, California
Conditions: Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic, Cardiovascular Diseases, Coronary Artery Disease
Register for Updates
Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial
NCT05230225
Recruiting
The DETECT AS Trial is a randomized clinical trial and quality improvement initiative that seeks to investigate the impact of electronic provider notification of severe aortic stenosis (AS) on its management, on the utilization of aortic valve replacement (AVR), and on ethnic and racial disparities in AVR utilization. After the investigators identify patients in whom echocardiography shows severe aortic stenosis, defined by an aortic valve area (AVA) \<1.0cm2, the ordering provider of the echoc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Stenosis
Register for Updates
The HALT Biomarker Study
NCT04552275
Recruiting
The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatment of HALT with systemic anticoagulation; and to identify circulating proteins that predict the occurrence of HALT. The study population will be adult patients undergoing transfemoral transcatheter aor... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
11/02/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Aortic Stenosis, Hypo-attenuated Leaflet Thickening, Bioprosthetic Valve Degeneration
Register for Updates