The city of Rochester, New York, currently has 88 active clinical trials seeking participants for Cancer research studies.
Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy
Recruiting
This clinical trial tests how well a geriatric assessment (GA) with GA-directed treatment recommendations, compared to GA with usual care, works in identifying risk factors, reducing chemotherapy radiation toxicity and functional decline, and improving the overall quality of life in older patients with non-small cell lung cancer (NSCLC). Older patients with lung cancer undergoing chemotherapy are at an increased risk of adverse outcomes including treatment toxicity and functional and physical co... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
04/04/2024
Locations: University of Rochester, Rochester, New York
Conditions: Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Recruiting
This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual approach to monitoring disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: University of Rochester, Rochester, New York
Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Positive, Prognostic Stage IV Breast Cancer AJCC v8, Elevated CA15-3 or CEA or CA27-29
Study of CAbozantinib in Combination With AtezolizumaB for Muscle-Invasive BladdEr Cancer
Recruiting
This is an open-label phase II study assessing the activity of cabozantinib combined with atezolizumab in patients with resectable muscle-invasive urothelial carcinoma who are ineligible for cisplatin-based therapy or decline cisplatin-based therapy. Each cycle equals 21 days. The dose of atezolizumab is 1200 mg IV flat dose every 3 weeks (Day 1) plus cabozantinib 40 mg orally daily (Day 1 through Day 21). Patients will receive three cycles of treatment prior to cystectomy unless they discontinu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Bladder Cancer
A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms
Recruiting
This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.
Gender:
All
Ages:
60 years and above
Trial Updated:
04/02/2024
Locations: University of Rochester Medical Center/Wilmot Cancer Institute, Rochester, New York
Conditions: Cancer, Myeloid Neoplasm
Exercise and Cognitive Rehab in Older Cancer Survivors
Recruiting
The objective of the study is to evaluate the feasibility of a combined mobile health exercise and cognitive rehabilitation intervention and its effect on cognition in a single-arm pilot study that recruits cancer survivors.
Gender:
All
Ages:
60 years and above
Trial Updated:
04/01/2024
Locations: University of Rochester, Rochester, New York
Conditions: Cancer
Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening
Recruiting
This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
03/28/2024
Locations: University of Rochester, Rochester, New York
Conditions: Lung Cancer
Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients & Non-Cancer Control Subjects With Optional Sub-Study Research Brain MRI
Recruiting
Study is enrolling newly diagnosed breast cancer patients about to start chemotherapy and age-matched control participants. The investigator is trying to better understand the prevalence of cognitive difficulties in cancer patients receiving chemotherapy compared to the general population as well as what biological mechanisms may play a role in the development of these difficulties. Patients will be asked to complete six assessments over the course of approximately 5 months. Assessments 1,3, 4.5... Read More
Gender:
Female
Ages:
21 years and above
Trial Updated:
03/28/2024
Locations: University of Rochester, Rochester, New York
Conditions: Cancer Related Cognitive Difficulties, Breast Cancer Female
Ribociclib and Bicalutamide in AR+ TNBC
Recruiting
This is an open label, multi-institutional, single arm phase II trial of ribociclib in combination with bicalutamide in advanced AR+ triple-negative breast cancer. No randomization or blinding is involved.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2024
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Triple Negative Breast Cancer
Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers
Recruiting
Patient will be treated with neratinib, an aromatase inhibitor and trastuzumab for 24 weeks prior to surgery, following an initial 3 weeks of neratinib alone, aromatase inhibitor alone or the combination of neratinib and an aromatase inhibitor. A breast biopsy will be performed prior to Day 1 of week 4 of treatment. Following surgery, patients will receive standard of care HER2-directed and endocrine therapy at the treating physician's discretion.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Breast Cancer, HER2-positive Breast Cancer, ER Positive Breast Cancer, PR-Positive Breast Cancer
Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women
Recruiting
The goal of this clinical research study is to evaluate a method involving a blood test, called CA-125, that may be helpful in the early detection of ovarian cancer in women who are at low risk.
Gender:
Female
Ages:
Between 50 years and 74 years
Trial Updated:
03/07/2024
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Ovarian Cancer
A Single Arm Pilot Trial of a Social Network Intervention
Recruiting
The purpose of this study is to see if a social network support program (SOcial Networks to Activate Trust & Adherence or SONATA) is helpful for older individuals receiving cancer treatment. The SONATA program will last for about 4 months. There are a total of 6 coaching sessions. The first 5 sessions will be held approximately every 1 to 2 weeks. Session 6 or the final session will be held approximately 1 to 2 months after session 5. Each session will last for about 1 to 2 hours.
Gender:
All
Ages:
65 years and above
Trial Updated:
03/05/2024
Locations: University of Rochester, Rochester, New York
Conditions: Cancer
Study Comparing Two Different Schedules of Radiation for Early-stage Lung Cancer
Recruiting
This study's goal is to find out if the kind of side effects people experience from radiation is different depending on the schedule of their radiation treatment. Patients will be randomly assigned to either the 3 Fraction or 5 Fraction schedule of radiation. After patients complete radiation treatment, they will follow up with their radiation oncologist.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York
Conditions: Lung Cancer