There are currently 548 clinical trials in Charlotte, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Carolinas Medical Center, Carolinas Medical Center/Levine Cancer Institute, Novant Health Presbyterain Medical Center and Levine Cancer Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Harmony TPV Post-Approval Study
NCT05077774
Recruiting
The purpose of this study is to characterize the functionality of transcatheter implantation of the Medtronic Harmony Transcatheter Pulmonary Valve (TPV) achieved by real-world implanters.
Gender:
All
Ages:
All
Trial Updated:
04/04/2024
Locations: Atrium Health Levine Children's Hospital, Charlotte, North Carolina
Conditions: Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma
NCT05489887
Recruiting
This is a prospective, multicenter clinical trial in subjects with newly diagnosed high-risk neuroblastoma to evaluate the efficacy and safety of administering naxitamab with standard induction therapy. The initial chemotherapy will include 5 cycles of multi-agent chemotherapy. Naxitamab will be added to all 5 Induction cycles. Subjects with an ALK mutation or amplification will have ceritinib added to their treatment regimen as soon as results are available. We hypothesize that the addition of... Read More
Gender:
All
Ages:
Between 12 months and 21 years
Trial Updated:
04/04/2024
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: High-risk Neuroblastoma
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DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma
NCT04696029
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma.
Gender:
All
Ages:
21 years and below
Trial Updated:
04/04/2024
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Medulloblastoma
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Pediatric Precision Laboratory Advanced Neuroblastoma Therapy
NCT02559778
Recruiting
A prospective open label, multicenter study to evaluate the feasibility and acute toxicity of using molecularly guided therapy in combination with standard therapy followed by a Randomized Controlled Trial of standard immunotherapy with or without DFMO followed by DFMO maintenance for Subjects with Newly Diagnosed High-Risk Neuroblastoma.
Gender:
All
Ages:
22 years and below
Trial Updated:
04/04/2024
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Neuroblastoma
Register for Updates
Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
NCT04301843
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
All
Ages:
31 years and below
Trial Updated:
04/04/2024
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Neuroblastoma
Register for Updates
Neuroblastoma Maintenance Therapy Trial
NCT02679144
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg/m2 ± 250 mg/m2 BID (strata 1, 2, 3, and 4) OR 2500 mg/m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Gender:
All
Ages:
Between 1 year and 30 years
Trial Updated:
04/04/2024
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Neuroblastoma
Register for Updates
External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury
NCT04914689
Recruiting
Knee injuries, especially those to the ACL, are common among physically active people. Preventing these injuries from happening is critical to limiting the long-term pain, disability, and arthritis associated with these injuries. Our study is going to examine new ways to provide feedback about the way people move to determine if these are better at modifying movement patterns to prevent injury than current standard treatments. If you participate, you will be asked to undergo a movement analysis... Read More
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
04/02/2024
Locations: UNC Charlotte, Charlotte, North Carolina
Conditions: Anterior Cruciate Ligament Injuries
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A Study of DS-7011a in Patients With Systemic Lupus Erythematosus
NCT05638802
Recruiting
Systemic lupus erythematosus (SLE) is a systemic chronic autoimmune disease characterized by autoantibody production, inflammation, and tissue damage in multiple organs. Standard of care therapies used to treat SLE are only partially effective and have a wide range of toxicities. There is a need for more effective and safer therapies for patients with SLE.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/02/2024
Locations: Joint & Muscle Research Institute, Charlotte, North Carolina
Conditions: Systemic Lupus Erythematosus
Register for Updates
Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17
NCT03755804
Recruiting
This is a phase II study using risk and response-adapted therapy for low, intermediate and high risk classical Hodgkin lymphoma. Chemotherapy regimens will be based on risk group assignment. Low-risk and intermediate- risk patients will be treated with bendamustine, etoposide, Adriamycin® (doxorubicin), bleomycin, Oncovin® (vincristine), vinblastine, and prednisone (BEABOVP) chemotherapy. High-risk patients will receive Adcetris® (brentuximab vedotin), etoposide, prednisone and Adriamycin® (doxo... Read More
Gender:
All
Ages:
25 years and below
Trial Updated:
04/02/2024
Locations: St. Jude Affiliate Clinic at Novant Health Hemby Children's Hospital, Charlotte, North Carolina
Conditions: Hodgkin Lymphoma
Register for Updates
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
NCT05742763
Recruiting
The primary research purpose is to determine if the use of a drug therapy intervention (each study participant will be randomly assigned to receive one of 3 study medications which will be blinded from everyone, including the study participants, and all research staff (except the principal investigator), combined with a series of 3 injections of Platelet-Rich Plasma (PRP) into an osteoarthritic knee joint, leads to reductions in knee pain, and improvements in physical function. Improvements will... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
04/01/2024
Locations: QC Kinetix Franchise Group, LLC, 309 South Sharon Amity Rd, Ste 302, Charlotte, North Carolina
Conditions: Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
Register for Updates
To Compare the Efficacy and Safety of the HAV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
NCT05908084
Recruiting
The goal of this clinical trial is to compare the number of catheter-free days (CFD) and the rate and severity of any dialysis access-related infections between the HAV and AVF groups over 12 months in patients with end-stage renal disease (ESRD) needing hemodialysis (HD). Participants will be stratified by location of the vascular access (forearm versus upper arm) and by type of AVF creation procedure planned by the surgeon at randomization (1-stage AVF versus 2-stage AVF). The comparator is a... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: Surgical Specialists of Charlotte, Charlotte, North Carolina
Conditions: End Stage Renal Disease (ESRD)
Register for Updates
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
NCT05172960
Recruiting
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects with symptomatic, severe, calcific aortic stenosis (AS).
Gender:
All
Ages:
All
Trial Updated:
03/29/2024
Locations: Carolinas Health System, Charlotte, North Carolina +1 locations
Conditions: Aortic Stenosis, Severe
Register for Updates