There are currently 552 clinical trials in Charlotte, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Carolinas Medical Center, Carolinas Medical Center/Levine Cancer Institute, Novant Health Presbyterain Medical Center and Levine Cancer Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer
NCT04072952
Recruiting
This is a Phase 1/2 dose escalation and cohort expansion study and will assess the safety, tolerability and anti-tumor activity of ARV-471 alone and in combination with palbociclib (IBRANCE®) in patients with estrogen receptor positive/human epidermal growth factor receptor 2 negative (ER+/HER2-) locally advanced or metastatic breast cancer, who have received prior hormonal therapy and chemotherapy in the locally advanced/metastatic setting.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/02/2023
Locations: Clinical Trial Site, Charlotte, North Carolina
Conditions: Breast Cancer
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Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients
NCT05014646
Recruiting
This phase II trial studies the effects of leflunomide in treating African-American and European-American patients with high-risk smoldering multiple myeloma. Leflunomide is used to decrease the body's immune response and may delay the symptoms of multiple myeloma in patients of African-American and European decent.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: Atrium Health University City/LCI-University, Charlotte, North Carolina
Conditions: Smoldering Plasma Cell Myeloma
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National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
NCT02852031
Recruiting
The purpose of this initiative is to improve care and outcomes for infants with HLHS by expanding the NPC-QIC national registry to gather clinical care process, outcome, and developmental data on infants with HLHS between diagnosis and 12 months of age, by improving the use of standards into everyday practice across pediatric cardiology centers, and by engaging parents as partners in the process.
Gender:
All
Ages:
15 months and below
Trial Updated:
05/15/2023
Locations: Levine Children's Hospital-Sanger Heart and Vascular Institute, Charlotte, North Carolina
Conditions: Hypoplastic Left Heart Syndrome (HLHS)
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Parks & Pediatrics Fit Together
NCT05455190
Recruiting
The proposed project will test an implementation strategy (the "TrailGuide") for delivering an existing model of pediatric obesity treatment ("Fit Together") that has demonstrated ability to meet published recommendations for improving health outcomes of children with obesity.
Gender:
All
Ages:
Between 6 years and 11 years
Trial Updated:
05/10/2023
Locations: Michael Jordan Family Medical Clinic (Freedom Drive Location) (NHPMCF), Charlotte, North Carolina
Conditions: Pediatric Obesity, Implementation
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Study of ADI-PEG 20, Venetoclax and Azacitidine in Acute Myeloid Leukemia
NCT05001828
Recruiting
Pegylated arginine deiminase (ADI-PEG 20) will be combined with venetoclax and azacitidine for treatment of subjects with previously treated or untreated with high risk factor acute myeloid leukemia (AML). Venetoclax and azacitidine are front-line therapy for such patients, and ADI-PEG 20 will be added to this regimen in a phase IA/B study.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
05/09/2023
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Acute Myeloid Leukemia, Adult
Register for Updates
SWOG S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer
NCT04155034
Recruiting
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/02/2023
Locations: Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Conditions: Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma, Lung Small Cell Carcinoma
Register for Updates
The SKyRoCKeT Study
NCT05770817
Recruiting
The SKyRoCKeT Study (Surface-Knit and Reformulate CADENCE-Kids for Translation) will recruit a sex- and age-balanced sample of 360 young people 6-20 years of age to develop an integrative, physiologically-coherent age-cadence-log(metabolic equivalent, MET) surface-based model, reformulate the prior R21 CADENCE-Kids study (1; NCT01989104) by providing individualized, more precise, age-specific and coherent cadence-intensity thresholds, investigate additional differences by anthropometric factors,... Read More
Gender:
All
Ages:
Between 6 years and 20 years
Trial Updated:
05/02/2023
Locations: University of North Carolina at Charlotte, Charlotte, North Carolina
Conditions: Healthy
Register for Updates
PARTNER 3 Trial - Aortic Valve-in-Valve
NCT03003299
Recruiting
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.
Gender:
All
Ages:
All
Trial Updated:
05/01/2023
Locations: Carolina's Health System, Charlotte, North Carolina
Conditions: Aortic Stenosis, Aortic Stenosis, Severe
Register for Updates
Study of ORIC-944 in Patients With Metastatic Prostate Cancer
NCT05413421
Recruiting
The purpose of this study is to establish recommended Phase 2 dose (RP2D) and/or maximum tolerated dose (MTD) and preliminary antitumor activity of ORIC-944 in patients with metastatic prostate cancer.
Gender:
Male
Ages:
18 years and above
Trial Updated:
04/28/2023
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Metastatic Prostate Cancer, Neuroendocrine Prostate Cancer
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Observation of Perioperative Outcomes of Robotic Pancreaticoduodenectomy
NCT04171440
Recruiting
This is a multi-site prospective, single arm, observational study examining the outcomes of robotic pancreaticoduodenectomy.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/25/2023
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Pancreaticoduodenectomy
Register for Updates
Clinical Outcomes Study of the Nexel Total Elbow
NCT02469662
Recruiting
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: OrthoCarolina Research Institute, Charlotte, North Carolina
Conditions: Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis
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Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
NCT05268094
Recruiting
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will be performed by center and by single vs. two ventricle status. Participants will be followed through the first year of life.
Gender:
All
Ages:
Between 1 day and 30 days
Trial Updated:
04/12/2023
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Congenital Heart Disease in Children
Register for Updates