There are currently 548 clinical trials in Charlotte, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Carolinas Medical Center, Carolinas Medical Center/Levine Cancer Institute, Novant Health Presbyterain Medical Center and Levine Cancer Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.
NCT04549116
Recruiting
This is a multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority clinical study in women aged 35 to 42 years. This study will investigate the safety and efficacy of Progesterone-IBSA to support euploid embryo blastocyst implantation and early pregnancy after frozen embryo transfer (FET) in a modified natural cycle as a treatment for infertile women. Subjects will be randomized to receive either active Progesterone-IBSA or Crinone 8% for luteal and early pregnancy... Read More
Gender:
Female
Ages:
Between 35 years and 42 years
Trial Updated:
03/04/2024
Locations: Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina
Conditions: Infertility
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Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
NCT00673842
Recruiting
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/01/2024
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Myocardial Infarction, Sudden Death
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Sponsor-Initiated OCS Heart Perfusion Registry
NCT05915299
Recruiting
OHP-II Registry is a sponsor-initiated, multi-center, observational post-approval registry.
Gender:
All
Ages:
All
Trial Updated:
02/29/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Heart Transplant
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PRO1160 for Advanced Solid and Liquid Tumors (PRO1160-001)
NCT05721222
Recruiting
Brief Summary: This study will test the safety, including side effects, and determine the characteristics of a drug called PRO1160 in participants with solid tumors. Participants will have solid tumor or liquid cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable). This Phase 1/2 study will have two parts. Part A of the study will find out how much and how frequently PRO1160 should be given to participants. Part B will use the dose and schedule... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Levine Cancer Center, Charlotte, North Carolina
Conditions: Renal Cell Carcinoma, Nasopharyngeal Carcinoma, Non Hodgkin Lymphoma
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Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
NCT03500328
Recruiting
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other complications associated with higher-efficacy treatments highlight the need to quantify their effectiveness in preventing disability. The TRaditional versus Ear... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/28/2024
Locations: Novant Health Neurology and Sleep, Charlotte, North Carolina
Conditions: Multiple Sclerosis, Relapsing-Remitting
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The POUR (Postoperative Urinary Retention) Study
NCT05276804
Recruiting
The primary aim of this study will be to compare the rate of postoperative urinary retention between patients receiving Sugammadex and those receiving traditional reversal agents
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Postoperative Urinary Retention
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Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo
NCT04096170
Recruiting
We aim to study the impact of perioperative IV lidocaine on postoperative pain control in patients undergoing paraesophageal hernia repair. This is in the context of an established ERAS protocol. We wish to study the effect of IV Lidocaine on postoperative short and long-term outcomes, including patients' length of stay postoperative mortality, morbidity, and quality of life. We will compare this to our standard pain management.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Atrium Health - Carolinas Medical Center, Charlotte, North Carolina
Conditions: Hernia, Paraesophageal
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Project: Every Child for Younger Patients With Cancer
NCT02402244
Recruiting
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
Gender:
All
Ages:
25 years and below
Trial Updated:
02/27/2024
Locations: Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina +1 locations
Conditions: Central Nervous System Neoplasm, Childhood Immature Teratoma, Childhood Langerhans Cell Histiocytosis, Childhood Mature Teratoma, Congenital Mesoblastic Nephroma, Lymphoproliferative Disorder, Myeloproliferative Neoplasm, Stromal Neoplasm, Carcinoma In Situ, Malignant Solid Neoplasm, Desmoid Fibromatosis, Ganglioneuroma, Melanocytic Neoplasm, Neuroendocrine Neoplasm
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A Study to Evaluate Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx) in Patients With Polycythemia Vera
NCT05143957
Recruiting
The main purpose of this study is to evaluate the efficacy of sapablursen in reducing the frequency of phlebotomy and in improving quality of life assessments in participants with polycythemia vera.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
02/23/2024
Locations: Atrium Health Levine Cancer Institute, Charlotte, North Carolina
Conditions: Phlebotomy Dependent Polycythemia Vera
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Ph I Study in Adult Patients With Relapsed or Refractory Multiple Myeloma
NCT05027594
Recruiting
This is a Phase I, first-in-human (FIH), open-label, non-randomized, multi-center study to explore the safety, tolerability, pharmacokinetics and preliminary antitumor activity of NMS-03597812 in adult patients with RRMM who have exhausted standard treatment options that are expected to provide meaningful clinical benefit or for whom standard therapy is considered unsuitable.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Multiple Myeloma
Register for Updates
SG2501 Safety Study in Subjects With Relapsed or Refractory Hematological Malignancies and Lymphoma.
NCT05293912
Recruiting
This is a phase Ia/Ib, first-in-Human, open-Label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of SG2501 in subjects with relapsed or refractory hematological malignancies and lymphoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Novant Health Forsyth Medical Center, Charlotte, North Carolina
Conditions: Hematological Malignancy, Lymphoma
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Pressure Relief Education and Training for Wheelchair Users
NCT06252597
Recruiting
There can be barriers for clients with progressive disorders who are power wheelchair users and their caregivers that prohibit them from performing pressure relief. Clients may struggle with consistent performance of pressure relief and may not recall the importance, have methods to perform, or be able to perform due to weakness or other disease changes.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Carolinas Neuromuscular ALS/MDA Center, Charlotte, North Carolina
Conditions: Pressure Area
Register for Updates