There are currently 548 clinical trials in Charlotte, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Carolinas Medical Center, Carolinas Medical Center/Levine Cancer Institute, Novant Health Presbyterain Medical Center and Levine Cancer Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML)
NCT04964518
Recruiting
This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy and PK of APG-2575 in combination with Azacitidine in the patients with AML/MPAL or MDS/CMML. The study consists of dose escalation (Part I) and dose expansion phase (Part II)
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
10/23/2023
Locations: Novant Health, Charlotte, North Carolina
Conditions: AML, Adult
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Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine
NCT05994703
Recruiting
This study will evaluate the effects of a reward devaluation strategy, which has been researched in the past, combined/augmented with the medication d-cycloserine in assisting smokers to switch from combustible cigarette (CC) to Juul.
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
10/20/2023
Locations: Rose Research Center, Charlotte, North Carolina
Conditions: Smoking Cessation, Harm Reduction
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Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study
NCT05301335
Recruiting
The purpose of this study is to evaluate the effectiveness and safety of SCONE neuromodulation therapy after 12 weeks of therapy in comparison to inactive sham control in improving symptoms of Neurogenic Lower Urinary Tract Dysfunction
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/19/2023
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Neurogenic Bladder, Stroke, Multiple Sclerosis, Spinal Cord Injuries (Complete and Incomplete)
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Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients
NCT05586971
Recruiting
The aim of this 12-month randomized multi-regional double-blind parallel group allopurinol and placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/17/2023
Locations: Presbyterian Hospital, Charlotte, North Carolina
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
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Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility
NCT01354002
Recruiting
The aims of this protocol are: to collect and store diseased and normal tissue and body fluid samples from new and returning patients at St. Jude Children's Research Hospital (SJCRH), affiliated sites and collaborating institutions; to collect and store samples from relatives of SJCRH patients; to collect and store retrospective and prospective pertinent corresponding clinical and laboratory data on disease characterization, treatment, and outcome; and to serve as a source of human biological sa... Read More
Gender:
All
Ages:
All
Trial Updated:
10/09/2023
Locations: St. Jude Affiliate Clinic at Novant Health Hemby Children's Hospital, Charlotte, North Carolina
Conditions: Normal and Diseased Tissue and Body Fluids Samples
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Desara ® One Single Incision Sling 522 Study
NCT04772131
Recruiting
A post-market study to compare the safety and effectiveness of the Desara® One Single Incision Sling (SIS), when compared to that of an FDA cleared transobturator sling over a period of 36 months.
Gender:
Female
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: Novant Health Urogynecology, Charlotte, North Carolina
Conditions: Stress Urinary Incontinence
Register for Updates
CentriMag Failure-to-Wean Post Approval Study
NCT04464785
Recruiting
The primary objective of this Post Approval Study is to report the proportion of patients surviving to 30 days post CentriMag support or to hospital discharge, whichever is longer. For subjects who do not recover and are bridged to a heart transplant or a long-term assist device, the primary endpoint is survival to induction of anesthesia for the surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/05/2023
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Heart Failure
Register for Updates
EF-36/Keynote B36: A Pilot, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Pembrolizumab for First Line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer
NCT04892472
Recruiting
This is a multicenter, randomized, open-label study of Tumor Treating Fields (TTFields) at 150 kHz to the thorax using the NovoTTF-200T System with IV pembrolizumab in subjects previously untreated for advanced or metastatic, PD-L1 positive non-small cell lung cancer (NSCLC). The primary objective is to evaluate the progression-free survival (PFS) by RECIST 1.1 in subjects with TPS ≥1 percent, 1L metastatic/current advanced NSCLC treated with TTFields concomitant with pembrolizumab compared to t... Read More
Gender:
All
Ages:
22 years and above
Trial Updated:
10/04/2023
Locations: Oncology Specialists of Charlotte, Charlotte, North Carolina
Conditions: Non-small Cell Lung Cancer
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A Comparison of the Outcomes in Fortiva and Strattice Mesh
NCT05572021
Recruiting
A comparison of ventral hernia repair with Strattice and Fortiva mesh.Primary The study team aims to determine the hernia recurrence rates for RTI Surgical biologic mesh (Fortiva) compared to Strattice. Also the study team aims to determine the mesh related complications for RTI Surgical biologic mesh (Fortiva) compared to Strattice
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
10/03/2023
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Ventral Hernia
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Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction
NCT05093959
Recruiting
Met-PEF will be a randomized, double-blind, placebo-controlled trial to examine the effects of 20 weeks of 1500 mg/day of metformin on physical function, quality of life (QOL), microbiome diversity, leaky gut, and systemic inflammation in patients with 80 older patients with heart failure with preserved ejection fraction (HFpEF).
Gender:
All
Ages:
60 years and above
Trial Updated:
09/25/2023
Locations: Atrium Health Sanger Heart and Vascular Clinic Institute, Charlotte, North Carolina
Conditions: Heart Failure With Preserved Ejection Fraction
Register for Updates
OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
NCT03747458
Recruiting
This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo). For the PK sub-study, up to 14 subjec... Read More
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
09/22/2023
Locations: Allergy Asthma & Immunology Research Institute, Charlotte, North Carolina
Conditions: Bilateral Nasal Polyposis
Register for Updates
Study of ORIC-533 in Relapsed or Refractory Multiple Myeloma
NCT05227144
Recruiting
The purpose of this study is to establish the Recommended Phase 2 Dose (RP2D), safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antimyeloma activity of ORIC-533 in patients with multiple myeloma who have exhausted available treatment options
Gender:
All
Ages:
18 years and above
Trial Updated:
09/19/2023
Locations: The Charlotte-Mecklenburg Hospital Authority d/b/a Atrium Health, Charlotte, North Carolina
Conditions: Relapsed or Refractory Multiple Myeloma
Register for Updates