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Degenerative Disc Disease Clinical Trials
A listing of 23 Degenerative Disc Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 23
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Clinical Trial Phase
There are currently 23 active clinical trials seeking participants for Degenerative Disc Disease research studies. The states with the highest number of trials for Degenerative Disc Disease participants are California, Texas, Florida and North Carolina.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Transcranial Magnetic Stimulation (TMS) for Obsessive Compulsive Disorder (OCD)
Recruiting
Transcranial magnetic stimulation (TMS) is an FDA-approved, non-invasive form of brain stimulation for OCD. TMS has been shown to be an effective form of treatment in individuals with OCD. By using a form of TMS termed theta-burst stimulation (TBS), we hope that this will result in a more effective treatment by producing faster symptom reduction. We are trialing a novel form of accelerated TMS, where we will deliver ten 10-minute sessions per day, for 5 days. This study will compare the efficacy of TMS for OCD at two distinct brain regions. Participants will be randomized into one of two study groups, and receive stimulation at either the DMPFC or R-OFC. Both regions have been linked to OCD by research. Patients that don't respond to their study region will have the option to receive stimulation at the other region.
Conditions:
Obsessive-Compulsive Disorder
Obsessive Compulsive Disorder
Obsessive Compulsive Disorder (OCD)
Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive Disorders and Symptoms
Featured Trial
Type 2 Diabetes Clinical Trial
Recruiting
Can changing your breakfast improve your type 2 diabetes? Join this online study from the University of Michigan.
Conditions:
Type 2 Diabetes
Diabetes Mellitus Type 2 in Obese
Diabetes Type Two
Featured Trial
Gout Clinical Research Study
Recruiting
Struggling to manage gout flares? Are you familiar with the side effects of urate lowering treatments? You may be able to help our clinical study develop safer and more effective medicines to reduce uric acid and ease inflammation.
Eligible participants will receive study-related medical care at no cost.
Eligible participants will receive study-related medical care at no cost.
Conditions:
Gout
Gout Flare
Acute Gout
Chronic Gout
Gout Attack
Investigation of DEXA-C Anterior Cervical Interbody System
Recruiting
FDA Cleared interbody product for the cervical spine, designed to match a patients DEXA scan for increase in fusion rate.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/27/2025
Locations: UCI Center for Clinical Research, Orange, California +3 locations
Conditions: Degenerative Disc Disease
MagnetOs Flex Matrix Compared to Trinity Elite Mixed with Local Autograft in Patients Undergoing Up to Four-level Instrumented Posterolateral Fusion
Recruiting
This is a phase IV post-marketing study for MagnetOs Flex Matrix. MagnetOs Flex Matrix is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease and undergoing spinal fusion surgery.
In this study, MagnetOs Flex Matrix will be used according to the latest U.S. Instructions For Use, specifically as a bone graft extender mixed with autograft in a 1:1 vol.% in the posterolateral spine.
Trinity Elite will also be used a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/06/2025
Locations: Hartford Hospital, Hartford, Connecticut +3 locations
Conditions: Degenerative Disc Disease, Spine Fusion, Leg Pain and/or Back Pain
Single Position Spine Surgery Registry
Recruiting
The purpose of this study is to systematically, prospectively compare surgical fusion techniques for thoracolumbar spinal fusion patients and assess long-term patient outcomes and revision rates following surgery.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/01/2024
Locations: New England Baptist Hospital, Boston, Massachusetts +5 locations
Conditions: Spine Fusion, Spinal Stenosis, Degenerative Disc Disease
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
Recruiting
The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into a lumbar intervertebral disc compared to control through 12 months post-treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Alabama Ortho, Spine and Sports, PC, Birmingham, Alabama +5 locations
Conditions: Degenerative Disc Disease
ACDF Using Structural Allograft Vs. Tritanium C
Recruiting
This is an observational, descriptive, prospective and retrospective data collection study. The purpose of this study is to observe radiographic outcomes of patients who will undergo anterior cervical discectomy and fusion (ACDF) utilizing Tritanium C (Stryker Spine). The rate of fusion success and adverse events will be compared retrospectively to patients who underwent instrumented ACDF utilizing structural allograft bone with plates.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/25/2024
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania
Conditions: Degenerative Disc Disease
Personalized Spine Study Group (PSSG) Registry
Recruiting
The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to the patient-specific rods.
Gender:
ALL
Ages:
Between 10 years and 85 years
Trial Updated:
10/01/2024
Locations: Dr. Christopher Kleck, MD, Aurora, Colorado
Conditions: Scoliosis; Adolescence, Degenerative Disc Disease, Spinal Fusion, Kyphoscoliosis, Pseudoarthrosis of Spine, Spinal Stenosis, Kyphoses, Scheuermann
Anterior Cervical Disectomy and Fusion Using the Tritanium® C Anterior Cervical Cage for One or Two-Levels
Recruiting
This is a prospective, single arm clinical study to evaluate fusion status and patient reported outcomes utilizing the Stryker Tritanium® C Anterior Cervical interbody device at one or two contiguous levels. Subjects that are recommended for surgical treatment of either a 1- or 2-level ACDF (Anterior Cervical Discectomy and Fusion) between the levels of Cervical Spine 2 to Thoracic 1 (C2-T1) and diagnosed with degenerative disc disease will be screened for the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Conditions: Cervical Disc Herniation, Cervical Disc Degeneration, Degenerative Disc Disease
Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
Recruiting
The brief purpose of this research study is to learn about the safety, tolerability, and efficacy of paraspinal intramuscular injection of CELZ-201-DDT in patients with chronic lower back pain.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/30/2024
Locations: Spine and Wellness Centers of America, Aventura, Florida
Conditions: Chronic Low-back Pain, Degenerative Disc Disease
OssDsign® Spine Registry Study ("Propel")
Recruiting
The purpose of this multi-center, prospective, observational registry is to gather information on the clinical outcomes and real-world use of commercially available bone graft substitutes manufactured by OssDsign® AB, in patients who require spine fusion.
Gender:
All
Ages:
21 years and above
Trial Updated:
05/20/2024
Locations: Community Health Partners Neuroscience, Fresno, California +11 locations
Conditions: Degenerative Disc Disease, Spinal Stenosis
Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery
Recruiting
The proposed intervention will examine two alternative methods for postoperative pain control. Two treatment arms of this study will include subjects who receive an erector spinae block (ESP) after induction of anesthesia but prior to the start of surgery and subjects who will receive a high volume of local anesthetic infiltration at the end of the procedure before emergence from anesthesia. The control group of subjects will undergo spinal surgery with general anesthesia but without any regiona... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/16/2024
Locations: University of Iowa Health Care Medical Center, Iowa City, Iowa
Conditions: Postoperative Delirium, Pain, Postoperative, Degenerative Disc Disease
Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft.
Recruiting
The objectives of this longitudinal study are to assess and measure fusion status (fused or not fused) and rate of bony fusion using NanoBone® Synthetic Bone Graft in patients requiring one to two level lumbar posterolateral fusion procedures with or without commercially available rigid spinal instrumentation. Our hypothesis is that the Nanobone synthetic bone graft will be as effective at creating a fusion in the lumbar spine as compared with a local bone graft. Each subject will serve as their... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/10/2024
Locations: UMass Memorial Health Care, Worcester, Massachusetts
Conditions: Degenerative Disc Disease, Spondylolisthesis
Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages
Recruiting
The purpose of this randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo combined interbody/posterolateral lumbar fusion procedures, supplemented with pedicle screw instrumentation, using one of the following interbody cages; the Medtronic Adaptix™ cage with roughened micro and nano-textured titanium surfaces or the CAPSTONE® poly-ether-ether-ketone cage.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/03/2024
Locations: The Ohio State University Wexner Medical Center Neurological Surgery, Columbus, Ohio
Conditions: Spinal Canal Stenosis, Spondylolisthesis, Osteophyte, Bony Growth Formation, Degenerative Disc Disease
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