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Cincinnati, OH Clinical Trials

A listing of Cincinnati, OH Clinical Trials actively recruiting patient volunteers.

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1165 trials found

Featured Trials

A Vaccine Trials for Healthy Young Adults (18-30)

Recruiting

The Eclipse Trial is evaluating the safety and immune response of an investigational vaccine, called mRNA-1189, that may protect against mono.

Conditions: Healthy, Healthy Volunteer

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Featured Trials

A Vaccine Trial For Healthy Women Between 16-40

Recruiting

A Cytomegalovirus (CMV) Investigational Vaccine Clinical Trial for Healthy Women Age 16 to 40. Compensation included.

Conditions: Healthy Volunteers, Healthy

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Featured Trials

RSV Vaccine For Adults 65+

Recruiting

The VANIR Study is a randomized, double-blind, phase 3 trial to assess the clinical efficacy and safety of the recombinant MVA-BN®-RSV vaccine in adults over 60.

Conditions: Healthy Volunteers, Healthy

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Featured Trials

Myelofibrosis Clinical Trial

Recruiting

This clinical trial is testing an investigational drug called selinexor for adults with previously treated myelofibrosis.

Conditions: Primary Myelofibrosis (PMF), Myelofibrosis, Bone Marrow Cancer, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis, Secondary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, Myelofibrosis (MF)

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Featured Trials

Atopic Dermatitis Clinical Trial

Recruiting

A Clinical Trial to Learn More About an Experimental Oral Treatment for Moderate to Severe Atopic Dermatitis

Conditions: Atopic Dermatitis, Dermatitis, Atopic, Atopic Dermatitis Eczema, Moderate-to-Severe Atopic Dermatitis, Mild to Moderate Atopic Dermatitis, Eczema, Hand Eczema, Dry Skin; Eczema

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Featured Trials

Non-Small Cell Lung Cancer Treatment

Recruiting

A Trial to Evaluate DZD9008 as a Treatment for People with Non-Small Cell Lung Cancer with EGFR Gene Mutations

Conditions: NSCLC

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Featured Trials

Alzheimer’s Disease Clinical Trial

Recruiting

A Clinical Trial to Learn More About an Investigational Treatment for Mild to Moderate Alzheimer’s Disease.

Conditions: Alzheimer Dementia, Dementia Alzheimers, Dementia, Alzheimer Type, Dementia of Alzheimer Type, Dementia, Frontotemporal Dementia, Dementia With Lewy Bodies

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Featured Trials

Autism Spectrum Clinical Trial

Recruiting

The purpose of these clinical studies is to determine how effective investigational medications are at helping treat Autism Spectrum Disorder (ASD). You may qualify if you have been diagnosed with Autism.

Conditions: Autism, Autism Spectrum Disorder, Autism Spectrum Disorder (ASD), High-functioning Autism, Autism Spectrum Disorders, Autism Disorder, Children With Autism

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Featured Trials

Osteoarthritis of the Knee Clinical Trial

Recruiting

The purpose of these clinical studies is to determine how effective investigational medications are at treating Osteoarthritis of the Knee. You may qualify to participate if you have been diagnosed with Osteoarthritis of the Knee.

Conditions: Osteoarthritis, Knee Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis of the Knee, Osteoarthritis, Hip

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Featured Trials

Endometriosis Clinical Trial

Recruiting

The purpose of these clinical studies is to determine how effective investigational medications are at treating Endometriosis. You may qualify to participate if you have been diagnosed with Endometriosis.

Conditions: Endometriosis, Endometriosis Ovary, Endometriosis, Rectum, Endometriosis-related Pain, Endometriosis Related Pain, Deep Infiltrating Endometriosis

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Featured Trials

Parkinson's Clinical Trial

Recruiting

The purpose of these clinical studies is to determine how effective investigational medications are at helping treat Parkinson's Disease. You may qualify to participate if you have been diagnosed with Parkinson's Disease.

Conditions: Parkinsonian Disorders, Vascular Parkinsonism

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Featured Trials

Narcolepsy Clinical Trial

Recruiting

This is a study evaluating the effectiveness of an investigational oral medication for adults with Narcolepsy. Participants who qualify for the study will receive trial-related medical care, tests and trial medication and may be compensated for time and travel.

Conditions: Narcolepsy, Sleep, Obstructive Sleep Apnea, Sleep Disorder

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Featured Trials

PTSD Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational oral medication for post-traumatic stress disorder (PTSD). Participants who qualify for the study will receive trial-related procedures and study medication at no cost and may be compensated for time and travel.

Conditions: PTSD, Post-Traumatic Stress Disorder, Stress Disorders, Post-Traumatic, Post-Traumatic Stress Disorders, Stress, Anxiety, Anxiety Disorders

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Featured Trials

Nash Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational oral medication alongside an approved injectable diabetes medication for cirrhosis due to non-alcoholic steatohepatitis (NASH).

Conditions: NASH - Nonalcoholic Steatohepatitis, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease, Fatty Liver, Nonalcoholic, Nonalcoholic Fatty Liver, Nonalcoholic Fatty Liver Disease (NAFLD), Steatohepatitis, Nonalcoholic, Non-Alcoholic Fatty Liver Disease, Fatty Liver, Non Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver

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Featured Trials

Migraines Clinical Study

Recruiting

The studies are to see how effective investigational medications are at helping to treat Migraines. You may qualify if you have been diagnosed with Migraines.

Conditions: Migraine, Migraine Disorders, Migraine Headache, Chronic Migraine, Migraine Without Aura, Migraine With Aura, Headache, Migraine, Episodic Migraine, Migraine Headaches, Acute Migraine, Acute Migraine Headache

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Featured Trials

Eczema Clinical Trial for Children & Adolsecents

Recruiting

Enrolling candidates diagnosed with Atopic Dermatitis (Eczema). Compensation available.

Conditions: Atopic Dermatitis, Eczema, Atopic Dermatitis Eczema, Dermatitis, Atopic

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Featured Trials

Relapsing-Remitting Multiple Sclerosis Clinical Trial

Recruiting

A new Clinical Study for Relapsing-Remitting Multiple Sclerosis treatment is seeking volunteers in your area. Participants receive:

- No-cost Study Medication
- No-cost Appointments
- Potential Financial Compensation

Conditions: Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting

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Featured Trials

A mRNA Vaccine Trial for Adults

Recruiting

A clinical trial evaluating investigational mRNA vaccines in adults

Conditions: Healthy Volunteers

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Featured Trials

Low Testosterone Clinical Trial

Recruiting

This is a clinical research study to test the effects of three different FDA-approved testosterone products on blood pressure. Participants will receive trial-related medical care, tests and trial medication and may be compensated for time and travel.

Conditions: Low Testosterone, Hypogonadism, Testosterone Deficiency

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Featured Trials

A Vaccine Trial For Adults 50+

Recruiting

A clinical trial for an investigational respiratory syncytial virus (RSV) vaccine combined with an investigational COVID-19 booster vaccine for older adults.

Conditions: Healthy Volunteers, Healthy

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Featured Trials

A Hodgkin Lymphoma (HL) Clinical Trial

Recruiting

A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

Conditions: Hodgkin Lymphoma, Peripheral T Cell Lymphoma, T Cell Lymphoma, Hodgkin Disease, Recurrent Adult Hodgkin Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Recurrent Non-Hodgkin Lymphoma, Classical Hodgkin Lymphoma, Stage IV Adult Hodgkin Lymphoma, Peripheral T-cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, T-cell Lymphoma

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Featured Trials

A Myelofibrosis Treatment Clinical Trial

Recruiting

To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)

Conditions: Primary Myelofibrosis (PMF), Myelofibrosis, Bone Marrow Cancer, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis

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Featured Trials

A Melanoma Treatment Clinical Trials

Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Conditions: Melanoma, Solid Tumor, NSCLC, Melanoma (Skin), Metastatic Melanoma, Malignant Melanoma, Solid Tumors, Advanced Solid Tumors, Advanced Solid Tumor, Non Small Cell, Non Small Cell Lung Carcinoma

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Featured Trials

Cholangitis (PBC + PSC) Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational medication for chronic itching due to Primary Biliary Cholangitis (PBC) or Primary Sclerosing Cholangitis (PSC). If enrolled, you will receive either the medication being tested in this study or a placebo (an inactive substance) to be taken once daily for 6 weeks. After that, everybody will receive the study medication for an additional 6 weeks. Participants who qualify for the study will receive trial-related procedures and study medication at no cost, and you may be compensated up to $1,350 if you complete the study.

Conditions: Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC)

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Featured Trials

A COVID-19 Vaccine Study For Teenagers

Recruiting

An investigational COVID-19 vaccine study for adolescents

Conditions: Healthy Volunteers

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Featured Trials

A Peripheral T Cell Lymphoma Clinical Trials

Recruiting

Assessing An Oral Janus Kinase Inhibitor, AZD4205 as Monotherapy in Patients Who Have PTCL (JACKPOT8)

Conditions: Peripheral T Cell Lymphoma (PTCL), Relapsed or Refractory

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Featured Trials

A Hodgkin Lymphoma (HL) + Peripheral T Cell Lymphoma Clinical Trial

Recruiting

A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma

Conditions: Hodgkin Lymphoma, Peripheral T Cell Lymphoma, Anaplastic Large Cell Lymphoma

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Featured Trials

A Diffuse Large B-Cell Lymphoma (DLBCL) Clinical Trial

Recruiting

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Conditions: Diffuse Large B-cell Lymphoma (DLBCL)

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Featured Trials

Meningitis Vaccine Clinical Studies for Ages 16-18

Recruiting

Help protect yourself and other teens and kids against meningitis by joining a clinical study!

Conditions: Healthy Volunteers

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Featured Trials

Meningitis Vaccine Clinical Studies for Ages 11-14

Recruiting

The purpose of this clinical study is to evaluate two different dosing schedules for an investigational meningococcal vaccine in preventing a meningitis infection in children, which is a serious and potentially life-threatening bacterial infection of the brain.

Conditions: Healthy Volunteers

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Featured Trials

Hepatitis B Clinical Studies

Recruiting

Hepatitis B Clinical Studies

Conditions: Hepatitis B

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Featured Trials

Asthma Clinical Studies

Recruiting

Asthma Clinical Studies

Conditions: Asthma

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Featured Trials

Clinical Studies for COPD

Recruiting

Clinical Studies for COPD

Conditions: COPD

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Featured Trials

Ulcerative Colitis Clinical Trials

Recruiting

Ulcerative Colitis Clinical Trials

Conditions: Ulcerative Colitis

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Featured Trials

Clinical Study for People at Risk of Developing Alzheimer's Disease

Recruiting

Clinical Studies for People at Risk of Developing Alzheimer's Disease

Conditions: Alzheimers, Dementia

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Featured Trials

Glaucoma Treatment Clinical Studies

Recruiting

The purpose of these clinical studies are to test the efficacy of treatments in reducing high eye pressure. You may qualify to participate if you have been diagnosed with open-angle glaucoma or ocular hypertension in one or both of your eyes.

Conditions: Glaucoma, Ocular Hypertension

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BEGIN Novel ImagiNG Biomarkers

NCT05517655

To determine the treatment effect of triple-combination therapy in 6-8 year olds after presumed FDA approval, using rapid structural and functional pulmonary and abdominal MRI (UTE and 129Xe).

Conditions: Cystic Fibrosis

Phase: Phase 4

Testing an App-Based Approach to Reading and Screen Time Guidance for Parents of Infants

NCT05508282

The American Academy of Pediatrics (AAP) recommends that parents read to their children as often as possible beginning in infancy and limits on screen time at all ages, yet many families question the value of reading to infants and are uncertain how to do so, and screen time is rising. This proposal is highly relevant to public health in that it involves a "how-to" approach to reading with infants and limiting screen time that is delivered during pediatric well-child visits within an established ...

Conditions: Literacy, Parent-Child Relations, Language Development

Phase: Not Applicable

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1)

NCT05501886

Conditions: Breast Cancer

Phase: Phase 3

Precision Alemtuzumab Dosing for Allogeneic Hematopoietic Cell Transplantation

NCT05501756

Alemtuzumab is an antibody that reduces the strength of the immune system that is given in preparation for allogeneic hematopoietic cell transplant (HCT). In this research study the investigators want to find out if they can adjust the dose of alemtuzumab used as part of allogeneic HCT to target the level of Day 0 (the planned day of graft infusion) to an optimal therapeutic window of 0.2-0.6 ug/mL.

Conditions: Allogeneic Hematopoietic Cell Transplantation

Phase: Phase 2

Safety and Immunogenicity of CJCV2 With and Without ALFQ

NCT05500417

This is a randomized, double-blind, dose-escalating, outpatient trial in a total of approximately 60 subjects, assigned to 3 cohorts (20 subjects per cohort). Each subject will receive one of three intramuscular (IM) vaccinations, spaced 28 days apart, of Campylobacter jejuni Conjugate Vaccine (CJCV2) with or without a fixed dose of the adjuvant Army Liposome Formulation containing QS-21 (ALFQ)(200 mcg 3D-PHAD, 100 mcg QS-21). Three doses (1 ug, 3 ug and 10 ug) of CJCV2 will be evaluated. The fi ...

Conditions: Campylobacter Infection

Phase: Phase 1

Safety and Efficacy of Intranasal Epinephrine After Administration of ARS -1 in Subjects With Frequent Urticaria Flares

NCT05496465

Determine the effect of ARS-1 on a patient reported pruritus/hive score

Conditions: Urticaria

Phase: Phase 2

Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer

NCT05498155

This study to learn more about olaparib and olaparib plus durvalumab combination therapy and also to better understand the studied disease, breast cancer, and associated health problems. Olaparib is a type of drug called a PARP (poly [adenosine diphosphate-ribose] polymerase) inhibitor. PARP inhibitors can destroy cancer cells that are not good at repairing DNA damage. Olaparib is also approved by US Food and Drug Administration (FDA), European Medicines Agency (EMA) and in other countries for ...

Conditions: Breast Cancer

Phase: Phase 2

Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours

NCT05489211

TROPION-PanTumor03 will investigate the safety, tolerability, and anti-tumour activity of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours.

Conditions: Endometrial Cancer, Gastric Cancer, Metastatic Castration-resistant Prostate Cancer, Ovarian Cancer, Colorectal Cancer

Phase: Phase 2

A Clinical Trial to Evaluate the Safety and Efficacy of ADX-629 in in Subjects With Elevated Ethanol Levels

NCT05487404

A Double-Blind Trial to Assess the Interaction Between ADX-629 and Ethanol While Exploring the Safety, Tolerability, and Activity of ADX-629 in Subjects With Elevated Ethanol Levels

Conditions: Ethanol Intoxication

Phase: Phase 1/2

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer

NCT05486143

This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3

Conditions: Breast Cancer

Phase: Phase 3

Safety and Immunogenicity Study of a Booster Dose of the Investigational CV0501 mRNA COVID-19 Vaccine in Adults at Least 18 Years Old

NCT05477186

Prevention of COVID-19 caused by SARS-CoV-2.

Conditions: SARS-CoV-2

Phase: Phase 1

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

NCT05476770

Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is pre ...

Conditions: Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia

Phase: Phase 1

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