The city of Cleveland, Ohio, currently has 8 active clinical trials seeking participants for Depression research studies.
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
NCT05711940
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Cleveland Clinic - Lutheran Hospital, Cleveland, Ohio
Conditions: Treatment Resistant Depression
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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NCT03887715
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: University Hospitals Case Medical Center, Cleveland, Ohio
Conditions: Treatment Resistant Depression
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Developing Resilience and Anxiety Management Through the Arts
NCT07033052
Recruiting
The Developing Resilience and Anxiety Management Through the Arts (DRAMA) Study examines the degree to which the arts can help to address stress, anxiety, and sad mood in children and adolescents. The researchers will pair theatrical improvisation exercises with cognitive-behavioral therapy (CBT) techniques versus improvisation exercises alone versus a social craft group on reducing elevated levels of anxiety and depression.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
07/16/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Anxiety, Depression, Mood
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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NCT06423430
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
07/07/2025
Locations: The Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Treatment Resistant Depression
Register for Updates
Abbreviated MBCT for Depression in Older African American/Black Breast Cancer Survivors
NCT06336538
Recruiting
The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
05/21/2025
Locations: Cleveland Clinic Department of Wellness and Preventive Medicine, Cleveland, Ohio
Conditions: Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Mild Depression, Moderate Depression
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Sequential Multiple Assignment Randomized Trial for Bipolar Depression
NCT06433635
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Bipolar I Disorder, Depression
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FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression
NCT06620042
Recruiting
This is a prospective open-label observational study of patients with treatment resistant bipolar depression referred for intravenous ketamine, with an interventional component of fMRI.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/17/2025
Locations: Cleveland Clinic Lutheran Hospital, Cleveland, Ohio
Conditions: Bipolar Depression, Treatment Resistant Bipolar Depression
Register for Updates
Positive Processes and Transition to Health - Single-Session (PATH-SS)
NCT06900712
Recruiting
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are: Does PATH-SS leads to improvements in PTSD and depressio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: PTSD, Depression
Register for Updates