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Cleveland, OH Clinical Trials

A listing of Cleveland, OH Clinical Trials actively recruiting patient volunteers.

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1300 trials found

Featured Trials

A Vaccine Trials for Healthy Young Adults (18-30)

Recruiting

The Eclipse Trial is evaluating the safety and immune response of an investigational vaccine, called mRNA-1189, that may protect against mono.

Conditions: Healthy, Healthy Volunteer

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Featured Trials

A Vaccine Trial For Healthy Women Between 16-40

Recruiting

A Cytomegalovirus (CMV) Investigational Vaccine Clinical Trial for Healthy Women Age 16 to 40. Compensation included.

Conditions: Healthy Volunteers, Healthy

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RSV Vaccine For Adults 65+

Recruiting

The VANIR Study is a randomized, double-blind, phase 3 trial to assess the clinical efficacy and safety of the recombinant MVA-BN®-RSV vaccine in adults over 60.

Conditions: Healthy Volunteers, Healthy

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Featured Trials

Myelofibrosis Clinical Trial

Recruiting

This clinical trial is testing an investigational drug called selinexor for adults with previously treated myelofibrosis.

Conditions: Primary Myelofibrosis (PMF), Myelofibrosis, Bone Marrow Cancer, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis, Secondary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, Myelofibrosis (MF)

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Featured Trials

Heart Failure Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an implantable investigational device called VITARIA for heart failure. Participants who qualify for the study will receive trial-related medical care, procedures, tests and study device at no cost.

Conditions: Heart Failure, Congestive Heart Failure, Chronic Heart Failure, Heart Failure, Congestive, Acute Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Acute Decompensated Heart Failure

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Featured Trials

Narcolepsy Clinical Trial

Recruiting

This is a study evaluating the effectiveness of an investigational oral medication for adults with Narcolepsy. Participants who qualify for the study will receive trial-related medical care, tests and trial medication and may be compensated for time and travel.

Conditions: Narcolepsy, Sleep, Obstructive Sleep Apnea, Sleep Disorder

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Featured Trials

PTSD Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational oral medication for post-traumatic stress disorder (PTSD). Participants who qualify for the study will receive trial-related procedures and study medication at no cost and may be compensated for time and travel.

Conditions: PTSD, Post-Traumatic Stress Disorder, Stress Disorders, Post-Traumatic, Post-Traumatic Stress Disorders, Stress, Anxiety, Anxiety Disorders

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Featured Trials

Nash Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational oral medication alongside an approved injectable diabetes medication for cirrhosis due to non-alcoholic steatohepatitis (NASH).

Conditions: NASH - Nonalcoholic Steatohepatitis, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease, Fatty Liver, Nonalcoholic, Nonalcoholic Fatty Liver, Nonalcoholic Fatty Liver Disease (NAFLD), Steatohepatitis, Nonalcoholic, Non-Alcoholic Fatty Liver Disease, Fatty Liver, Non Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver

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Featured Trials

A mRNA Vaccine Trial for Adults

Recruiting

A clinical trial evaluating investigational mRNA vaccines in adults

Conditions: Healthy Volunteers

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Featured Trials

Low Testosterone Clinical Trial

Recruiting

This is a clinical research study to test the effects of three different FDA-approved testosterone products on blood pressure. Participants will receive trial-related medical care, tests and trial medication and may be compensated for time and travel.

Conditions: Low Testosterone, Hypogonadism, Testosterone Deficiency

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Featured Trials

A Vaccine Trial For Adults 50+

Recruiting

A clinical trial for an investigational respiratory syncytial virus (RSV) vaccine combined with an investigational COVID-19 booster vaccine for older adults.

Conditions: Healthy Volunteers, Healthy

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Featured Trials

Alzheimer's Disease Study

Recruiting

New research opportunity for people with mild cognitive impairment or early stage Alzheimer's.

Male & Female, 50-80 Years Old

Conditions: Alzheimers, Dementia

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Featured Trials

Parkinson's Research Opportunity

Recruiting

Take your place in a new project exploring the genetics of Parkinson’s. Join our Parkinson’s research for the chance to receive a free genetic test.

Conditions: Parkinson's Disease, Parkinson Disease, Idiopathic Parkinson's Disease

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Featured Trials

A Hodgkin Lymphoma (HL) Clinical Trial

Recruiting

A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

Conditions: Hodgkin Lymphoma, Peripheral T Cell Lymphoma, T Cell Lymphoma, Hodgkin Disease, Recurrent Adult Hodgkin Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Recurrent Non-Hodgkin Lymphoma, Classical Hodgkin Lymphoma, Stage IV Adult Hodgkin Lymphoma, Peripheral T-cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, T-cell Lymphoma

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Featured Trials

A Myelofibrosis Treatment Clinical Trial

Recruiting

To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)

Conditions: Primary Myelofibrosis (PMF), Myelofibrosis, Bone Marrow Cancer, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis

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Featured Trials

A Melanoma Treatment Clinical Trials

Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Conditions: Melanoma, Solid Tumor, NSCLC, Melanoma (Skin), Metastatic Melanoma, Malignant Melanoma, Solid Tumors, Advanced Solid Tumors, Advanced Solid Tumor, Non Small Cell, Non Small Cell Lung Carcinoma

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Featured Trials

A COVID-19 Vaccine Study For Teenagers

Recruiting

An investigational COVID-19 vaccine study for adolescents

Conditions: Healthy Volunteers

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Featured Trials

A Peripheral T Cell Lymphoma Clinical Trials

Recruiting

Assessing An Oral Janus Kinase Inhibitor, AZD4205 as Monotherapy in Patients Who Have PTCL (JACKPOT8)

Conditions: Peripheral T Cell Lymphoma (PTCL), Relapsed or Refractory

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Featured Trials

A Hodgkin Lymphoma (HL) + Peripheral T Cell Lymphoma Clinical Trial

Recruiting

A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma

Conditions: Hodgkin Lymphoma, Peripheral T Cell Lymphoma, Anaplastic Large Cell Lymphoma

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Featured Trials

A Diffuse Large B-Cell Lymphoma (DLBCL) Clinical Trial

Recruiting

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Conditions: Diffuse Large B-cell Lymphoma (DLBCL)

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Featured Trials

Meningitis Vaccine Clinical Studies for Ages 16-18

Recruiting

Help protect yourself and other teens and kids against meningitis by joining a clinical study!

Conditions: Healthy Volunteers

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Featured Trials

Meningitis Vaccine Clinical Studies for Ages 11-14

Recruiting

The purpose of this clinical study is to evaluate two different dosing schedules for an investigational meningococcal vaccine in preventing a meningitis infection in children, which is a serious and potentially life-threatening bacterial infection of the brain.

Conditions: Healthy Volunteers

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Featured Trials

Hepatitis B Clinical Studies

Recruiting

Hepatitis B Clinical Studies

Conditions: Hepatitis B

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Featured Trials

Asthma Clinical Studies

Recruiting

Asthma Clinical Studies

Conditions: Asthma

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Featured Trials

Clinical Studies for COPD

Recruiting

Clinical Studies for COPD

Conditions: COPD

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Featured Trials

Ulcerative Colitis Clinical Trials

Recruiting

Ulcerative Colitis Clinical Trials

Conditions: Ulcerative Colitis

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Featured Trials

Clinical Study for People at Risk of Developing Alzheimer's Disease

Recruiting

Clinical Studies for People at Risk of Developing Alzheimer's Disease

Conditions: Alzheimers, Dementia

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Featured Trials

Glaucoma Treatment Clinical Studies

Recruiting

The purpose of these clinical studies are to test the efficacy of treatments in reducing high eye pressure. You may qualify to participate if you have been diagnosed with open-angle glaucoma or ocular hypertension in one or both of your eyes.

Conditions: Glaucoma, Ocular Hypertension

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International CDKL5 Clinical Research Network

NCT05558371

Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea ...

Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD

Phase: N/A

A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older

NCT05540522

This is a Phase 3, randomized, observer-blinded study to evaluate the efficacy, safety, tolerability, and immunogenicity of a single dose of a quadrivalent influenza modRNA vaccine compared to licensed inactivated influenza vaccine in healthy adults 18 years of age and older.

Conditions: Influenza, Human

Phase: Phase 3

Study of Tecovirimat for Human Monkeypox Virus

NCT05534984

A5418 is a randomized, placebo-controlled, double-blind study to establish the efficacy of tecovirimat for the treatment of people with laboratory-confirmed or presumptive HMPXV disease.

Conditions: Monkeypox

Phase: Phase 3

Digital PET/CT Using [Ga-68]PSMA vs. [F-18]NaF for Evaluation of Osseous Metastatic Involvement in Prostate Cancer Patients

NCT05527483

The purpose of this study is to evaluate a radioactive diagnostic study drug, which is called Gallium-68 Prostate Specific Membrane Antigen ([Ga-68]PSMA) for detection of bone metastasis in patients with prostate cancer. For imaging the investigators will use a FDA approved imaging technology, digital Positron Emission Tomography (PET/CT). The investigators would like to know if digital PET/CT using [Ga-68]PSMA provides accurate information about the extent of bone metastases. Therefore, the i ...

Conditions: Prostate Cancer

Phase: N/A

Clinical Trial of SOT102 Antibody Drug Conjugate in Patients With Advanced Gastric and Pancreatic Adenocarcinoma

NCT05525286

This trial will assess the MTD and RP2D of SOT102 administered as monotherapy (Part A) and in combination with first-line SoC treatment (mFOLFOX6 with nivolumab and nab-paclitaxel/ gemcitabine; Part B) and efficacy of SOT102 administered as monotherapy (Part C) and in combination with first-line SoC treatment (Part D) in patients with advanced inoperable or metastatic gastric/GEJ adenocarcinoma or inoperable or metastatic pancreatic adenocarcinoma.

Conditions: Gastric Cancer, Pancreatic Cancer, Gastro-Esophageal Junction Cancer

Phase: Phase 1/2

Improving Care for Women With Urinary Incontinence (EMPOWER)

NCT05515198

The overall goal is to improve diagnosis and non-operative management of urinary incontinence in women.

Conditions: Urinary Incontinence

Phase: Not Applicable

Fascial Defect Closure for Minimally Invasive Parastomal Hernia Repair

NCT05514600

Fascial closure was not originally a routine component of minimally invasive parastomal hernia repairs, but several recent advancements have made fascial closure more common in this context. These include barbed self-locking sutures that aid intracorporeal fascial closure under tension, and wristed instrumentation offered by the robotic platform when available. The investigator aims to characterize the clinical significance of closing the fascia adjacent to the stoma during a MIS parastomal hern ...

Conditions: Parastomal Hernia

Phase: Not Applicable

A Performance Evaluation Study of Arquer's MCM5 Elisa Test (ADXBLADDER) to Aid in the Monitoring of Recurrence in Non-Muscle Invasive Bladder Cancer

NCT05508568

The objective of this prospective, multi-centre study is to evaluate the performance of ADXBLADDER, a urine MCM5 ELISA test, as an aid in the detection of bladder cancer recurrence. Patients undergoing cystoscopic surveillance in non-muscle invasive bladder cancer (NMIBC) follow-up will be recruited and asked to provide a urine sample to be tested with ADXBLADDER. To assess the diagnostic accuracy of the test, the MCM5 results will be compared with the gold standard cystoscopy and pathology of r ...

Conditions: Bladder Cancer

Phase: N/A

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer

NCT05486143

This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3

Conditions: Breast Cancer

Phase: Phase 3

Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair

NCT05484635

This study is evaluating the management of chronic post-operative inguinal hernia pain and the impact of hernia mesh removal after previous minimally invasive inguinal hernia repairs. The study aims are to evaluate the change in chronic (>6 months), nociceptive, postoperative inguinal pain after mesh removal compared to no mesh removal in patients who have previously undergone minimally invasive inguinal hernia repair with pre-peritoneal mesh.

Conditions: Chronic Groin Pain, Hernia, Inguinal

Phase: Not Applicable

USCRI Ready4Life Program

NCT05476185

The U.S. Committee for Refugees and Immigrants (USCRI) has developed the Relationships, Education, Advancement, and Development for Youth for Life (READY4Life) Program. This is a 16-hour program for immigrants/refugees, ages 14 to 24. The program is designed to help young immigrants and refugees prepare for a successful life in the United States. The program is taught by USCRI program staff and is being implemented at eight sites across the U.S.: Cleveland, Ohio; Colchester, Vermont; Des Moines, ...

Conditions: Communication, Problem Solving, Social Relationships, Economic Stability

Phase: Not Applicable

Robotic Versus Open Ventral Hernia Repair

NCT05472987

This is a randomized trial comparing open retromuscular ventral hernia repair to robotic retromuscular ventral hernia repair.

Conditions: Ventral Hernia

Phase: Not Applicable

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