The state of Ohio currently has 21 active clinical trials seeking participants for Autism research studies. These trials are conducted in various cities, including Cincinnati, Columbus, Cleveland and Dayton.
Pimavanserin for the Treatment of Irritability Associated With Autism Spectrum Disorder
Recruiting
6-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group study in children and adolescents (aged 5 to17 years) with autism spectrum disorder (ASD) with irritability, agitation, or self-injurious behaviors to study the efficacy and safety of pimavanserin
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
03/06/2024
Locations: Quest Therapeutics of Avon Lake dba Haidar Almhana Nieding LLC, Avon Lake, Ohio +1 locations
Conditions: Irritability Associated With Autism Spectrum Disorder
Extension Study of Pimavanserin in Irritability Associated With Autism Spectrum Disorder
Recruiting
52-week, open-label extension study of double-blind study ACP-103-069 to determine the long-term safety and tolerability of pimavanserin for the treatment of irritability associated with ASD in children and adolescents (aged 5 to 17 years). ACP-103-069 is a 6-week, randomized, double-blind, fixed-dose, placebo controlled, parallel group study of pimavanserin in children and adolescents with irritability associated with autism spectrum disorder (ASD).
Gender:
All
Ages:
Between 5 years and 18 years
Trial Updated:
03/06/2024
Locations: Quest Therapeutics of Avon Lake dba Haidar Almhana Nieding LLC, Avon Lake, Ohio +1 locations
Conditions: Irritability Associated With Autism Spectrum Disorder
Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder
Recruiting
The purpose of this study is to evaluate the long-term safety and tolerability of cariprazine in the treatment of pediatric participants with schizophrenia, bipolar I disorder, or autism spectrum disorder (ASD) and to establish the benefit-risk profile of long-term treatment in this population.
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
03/04/2024
Locations: Quest Therapeutics of Avon Lake /ID# 235956, Avon Lake, Ohio +2 locations
Conditions: Schizophrenia, Bipolar I Disorder, Autism Spectrum Disorder (ASD)
Study of Cariprazine Oral Capsules or Solution to Assess Adverse Events and Change in Irritability Due to Autism Spectrum Disorder (ASD) in Participants Aged 5-17 Years With ASD
Recruiting
Autism spectrum disorder (ASD) consists of deficits in social, communication, and cognitive development, repetitive and stereotypic behaviors. Many ASD patients show notably high levels of irritability, including verbal and physical aggression, self injury, and/or property destruction. Autistic infants tend to avoid eye contact and show little interest in others. This study will assess how safe and effective cariprazine is in treating pediatric participants (5 to 17 years of age) with ASD. Adver... Read More
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
02/23/2024
Locations: Quest Therapeutics of Avon Lake /ID# 252013, Avon Lake, Ohio +2 locations
Conditions: Autism Spectrum Disorder
Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders
Recruiting
Fragile X Syndrome (FXS) is a complex neurodevelopmental disorder caused by a mutation on the X chromosome. Scientists have investigated FXS extensively in both humans and animals. Thus far, phenotypic rescue in animal models has not resulted in treatment breakthroughs in humans, though some important discoveries have been made. Research has shown that individuals with FXS process sounds differently than those in the typical population, and they also show baseline differences in brain activity,... Read More
Gender:
All
Ages:
Between 5 years and 15 years
Trial Updated:
02/21/2024
Locations: Elizabeth Blank, Cincinnati, Ohio
Conditions: Fragile X Syndrome, Autism Spectrum Disorder, Autistic Disorder, Asperger Syndrome
ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)
Recruiting
ML-004-002 is a multi-center, randomized, double-blind, parallel-group, placebo-controlled study that will enroll approximately 150 adolescent and adult subjects with ASD. The primary objective is to evaluate the efficacy of ML-004 compared with placebo in the improvement of social communication deficits in subjects with ASD.
Gender:
All
Ages:
Between 12 years and 45 years
Trial Updated:
02/09/2024
Locations: Ohio State University Nisonger Center, Columbus, Ohio
Conditions: Autism Spectrum Disorder
Management of ADHD in Autism Spectrum Disorder
Recruiting
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists. Findings from this study will help improve clinicians' approach to me... Read More
Gender:
All
Ages:
Between 4 years and 17 years
Trial Updated:
02/06/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio +1 locations
Conditions: ADHD, Autism Spectrum Disorder
Treatment Monitoring in Autism Spectrum Disorder (ASD) in Children
Recruiting
The goal of this clinical study is to learn about the utility and performance of the EarliPoint(™) System: Evaluation for Autism Spectrum Disorder to monitor changes in a child's verbal ability, non-verbal learning, and social disability over time in children ages 15-84 months with autism spectrum disorder or related developmental delays (DD) and in those who are typically developing. The main questions it aims to answer are: To estimate the change in each of the EarliPoint index scores in typ... Read More
Gender:
All
Ages:
Between 15 months and 84 months
Trial Updated:
02/02/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Autism Spectrum Disorder, Autism, Developmental Delay, Autism, Early Infantile, Autism, Infantile
Evaluating a Web Delivered Behavioral Parent Training Intervention for Rural Parents of Children With Autism Spectrum Disorder
Recruiting
For parents of children with autism spectrum disorder (ASD), the severity of the child's behavior negatively correlates with parental well-being. Parental education and support buffers stress and negative effects that some parents experience. Parents living in rural areas face several barriers to obtaining support, psychoeducation, and ASD interventions due to a lack of local resources. This pilot study will test the acceptability, feasibility and preliminary effects of Attend Behavior, a Web-b... Read More
Gender:
All
Ages:
Between 2 years and 11 years
Trial Updated:
01/23/2024
Locations: Ohio State University College of Nursing, Columbus, Ohio
Conditions: Autism Spectrum Disorder, Parenting, Parenting Intervention
A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Recruiting
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability... Read More
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
12/13/2023
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder
Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations
Recruiting
The purpose of this study is to determine cross-sectional and longitudinal medical, behavioral, and cognitive differences between PTEN ASD and other groups, as well as to identify cognitive, neural systems, and molecular biomarkers specific to PTEN ASD. In addition, this study will be creating and maintaining a biorepository and linked phenotypic database for PTEN ASD.
Gender:
All
Ages:
18 months and above
Trial Updated:
11/09/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio +1 locations
Conditions: PTEN, ASD, Autism, Macrocephaly, PTEN Hamartoma Tumor Syndrome
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
Recruiting
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive of ASD and ID presence and severity in patients with TSC. In addition, this study will be establishing infrastructure for the collection and storage of human bio-specimens, including genetic material, from TSC patients and their family members with ASD.
Gender:
All
Ages:
18 months and above
Trial Updated:
11/09/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Tuberous Sclerosis, Autism Disorder, Intellectual Disability