The state of Ohio currently has 24 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Cincinnati, Columbus, Cleveland and Dayton.
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: University Hospitals Case Medical Center, Cleveland, Ohio +3 locations
Conditions: Treatment Resistant Depression
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Insight Clinical Trials, LLC, Beachwood, Ohio +1 locations
Conditions: Treatment Resistant Depression
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
Recruiting
Evaluate the efficacy of accelerated theta burst stimulation (aTBS) in reducing depressive symptoms in autism spectrum disorder (ASD)
Gender:
ALL
Ages:
Between 13 years and 26 years
Trial Updated:
10/31/2024
Locations: Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio
Conditions: ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder, MDD
TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
Recruiting
The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=41) vs. enhanced waitlist (eWL, N=41) control in young (\<50 years) African American women who are depressed or suffering from stress, and at risk for hypertension.
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
10/04/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Depression
Academic-Community EPINET (AC-EPINET)
Recruiting
The investigators propose to examine the effects of CSC services delivered via TH (CSC-TH) versus the standard clinic-based CSC model (CSC-SD) on engagement and outcomes in a 12-month, randomized trial.
Gender:
ALL
Ages:
Between 16 years and 35 years
Trial Updated:
09/17/2024
Locations: The Early Psychosis Intervention Center (EPICENTER) at Ohio State, Columbus, Ohio
Conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Major Depression With Psychotic Features, Bipolar Disorder With Psychotic Features
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxious Depression, Depression
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients who are experiencing major depressive episodes (MDEs) associated with a primary diagnosis of bipolar I or bipolar II disorder as confirmed by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL), according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM 5).
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
07/26/2024
Locations: Clinical Site, Avon Lake, Ohio +2 locations
Conditions: Bipolar Depression
Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies
Recruiting
In this study, the investigators will test whether the incorporation of positive affect promoting activities in treatment sessions improves outcomes in the context of CBT for depression and DBT for problems of emotion dysregulation. In clinics focused on each of these treatments, the investigators will evaluate these treatments with and without the addition of positive affect promoting activities.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: Department of Psychology, The Ohio State University, Columbus, Ohio
Conditions: Depression, Borderline Personality Disorder, Emotion Regulation
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Recruiting
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/05/2024
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
Ketogenic Intervention in Depression
Recruiting
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on mental and metabolic health.
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Depression, Ketosis
CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Recruiting
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk.
Gender:
All
Ages:
Between 8 years and 75 years
Trial Updated:
02/05/2024
Locations: Clarigent Health, Mason, Ohio
Conditions: Suicide, Suicidal, Suicide, Attempted, Suicidal Ideation, Depression, Anxiety, Aggression, Trauma, Psychological
Outcomes Mandate National Integration With Cannabis as Medicine
Recruiting
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
Gender:
All
Ages:
7 years and above
Trial Updated:
05/29/2022
Locations: OMNI Medical Services, Beechwood, Ohio +4 locations
Conditions: Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma, Fibromyalgia, Seizures, Hepatitis C, Cancer, Crohn Disease, HIV/AIDS, Multiple Sclerosis, Traumatic Brain Injury, Sickle Cell Disease, Post Traumatic Stress Disorder, Tourette Syndrome, Ulcerative Colitis, Glaucoma, Epilepsy, Inflammatory Bowel Diseases, Parkinson Disease, Amyotrophic Lateral Sclerosis, Chronic Traumatic Encephalopathy, Anxiety, Depression, Insomnia, Autism, Opioid-use Disorder, Bipolar Disorder, Covid19, SARS-CoV Infection, COVID-19, Corona Virus Infection, Coronavirus