There are currently 1013 clinical trials in Portland, Oregon looking for participants to engage in research studies. Trials are conducted at various facilities, including Oregon Health & Science University, Oregon Health and Science University /ID# 216891, Providence Portland Medical Center and Providence Saint Vincent Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Oregon Health and Sciences University, Portland, Oregon
Conditions: Abdominal Aortic Aneurysm
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Immunogenicity of Yellow Fever Vaccine 17D in Adults With Prior 17D Vaccination
NCT05859490
Recruiting
The goal of this clinical trial is to assess the immune response to the yellow fever vaccine 17D in adults with prior 17D vaccination. The main questions this study aims to answer are: how does prior vaccination affect antibody responses to re-vaccination? how does prior vaccination affect the immune cell response to re-vaccination? Participants will: have been previously vaccinated with 17D. be re-vaccinated with 17D. provide medical and travel histories. provide a blood sample prior to vacc... Read More
Gender:
All
Ages:
Between 20 years and 49 years
Trial Updated:
09/26/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Yellow Fever, Immunization; Infection
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Whole Genome Sequencing (WGS) on IVF Embryos and Individual Patients
NCT05739890
Recruiting
This research project aims to utilise recent advances in whole genome sequencing of preimplantation genetic diagnosis embryos to investigate the impact of paternal age on de novo mutation rates in IVF embryos. Embryos that are deemed unsuitable for transfer following preimplantation genetic testing for monogenic/single gene disorders (PGT-M) due to the detection of genetic abnormalities will be utilized for this study. These embryos will undergo re-biopsy, and both the biopsied samples as well a... Read More
Gender:
All
Ages:
Between 18 years and 48 years
Trial Updated:
09/21/2023
Locations: ORM Fertility, Portland, Oregon
Conditions: Fertility Issues, Single-Gene Defects
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Part II: Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia
NCT04373941
Recruiting
The Investigators propose to test the hypothesis that GCSF enhances the clinical outcome of biliary atresia in a multi-institutional Phase 2 trial to prospectively evaluate the safety and efficacy of GCSF in each of the 2 groups of newly diagnosed BA patients: KBA (i.e., Kasai-operated) or NoK (i.e., patients who did not undergo Kasai surgery). Subjects who participate in the trial will be followed for 2 years.
Gender:
All
Ages:
Between 14 days and 180 days
Trial Updated:
09/07/2023
Locations: Oregon Health & Science University (OHSU), Portland, Oregon
Conditions: Biliary Atresia
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A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
NCT04143659
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Healthy Women, Female Contraception
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
All
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
NCT05902520
Recruiting
The subject of this study is the adoptive transfer of selected autologous tumor infiltrating lymphocytes (TIL) after in vitro expansion for the treatment of solid tumor malignancies. The TIL selection process is based on evidence showing that CD8+ TIL which co-express both CD39 and CD103 harbor the bulk of tumor-reactivity and that the remaining CD8 TIL is mainly composed of non-tumor reactive bystander cells. All of the expanded TIL that are produced (1-40 billion are expected) will be delivere... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Providence Portland Medical Center, Portland, Oregon
Conditions: HNSCC, Melanoma, Gynecologic Cancer, Colorectal Cancer, Lung Cancer, Urogenital Cancer
Register for Updates
Bringing Weight Management Into the Primary Care Pediatric Practice
NCT05950620
Recruiting
This project aims to move what is currently a specialty-care model for the management of obesity of children and adolescents into the primary care setting.
Gender:
All
Ages:
Between 1 month and 21 years
Trial Updated:
07/17/2023
Locations: The Children's Clinic, Portland, Oregon +1 locations
Conditions: Obesity, Childhood
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Ovarian Tissue Freezing For Fertility Preservation
NCT00902720
Recruiting
The purpose of this study is to offer an alternative method to women who wish to preserve the possibility of fertility, as well as to learn more about the ability of human eggs to survive and function after long term storage in frozen ovaries (ovarian tissue cryopreservation). The study will seek to preserve ovarian tissue and reproductive potential for patients whose medical or surgical treatment may harm ovaries or remove ovarian tissue.
Gender:
Female
Ages:
Between 18 years and 41 years
Trial Updated:
06/30/2023
Locations: Oregon Health and Sciences Universtiy, Portland, Oregon
Conditions: Malignancy, Fertility
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The Work-life Check-ins: a Supervisor-driven Intervention to Reduce Burnout in Primary Care
NCT05436548
Recruiting
The objective of this study is to evaluate the effectiveness and process of frequent supervisor-employee check-ins in reducing burnout among employees of primary care clinics in Portland, OR. Healthcare workers are at risk for burnout and associated adverse health and safety outcomes, including chronic diseases and occupational injuries. Not only does burnout affect healthcare workers, but burnout also affects the quality of patient care. The proposed study will create a check-in process between... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/27/2023
Locations: OHSU, Portland, Oregon +1 locations
Conditions: Burnout
Register for Updates
Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma
NCT04797884
Recruiting
The primary goals of this study are to compare overall survival and quality of life in subjects with Child-Pugh A or B advanced hepatocellular carcinoma when treated with a device emitting radiofrequencies modulated at specific frequencies or with a device emitting unmodulated radiofrequencies.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/25/2023
Locations: Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon
Conditions: Hepatocellular Carcinoma
Register for Updates
Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype
NCT05207709
Recruiting
HARMONIA is an international, multicenter, randomized, open-label and phase III study. The primary objective of this study is to demonstrate that the combination of ribociclib with endocrine therapy (letrozole or fulvestrant) is superior to palbociclib with endocrine therapy (letrozole or fulvestrant) in prolonging progression-free survival in patients with advanced HR+/HER2- and HER2-E breast cancer. The study will enroll approximately 456 patients with HER2-E disease from approximately 95 site... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2023
Locations: Legacy Good Samaritan Hospital and Medical Cente, Portland, Oregon
Conditions: Metastatic Breast Cancer
Register for Updates