There are currently 1011 clinical trials in Portland, Oregon looking for participants to engage in research studies. Trials are conducted at various facilities, including Oregon Health & Science University, Oregon Health and Science University /ID# 216891, Providence Portland Medical Center and Providence Saint Vincent Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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Intraocular Lens Power Calculation After Laser Refractive Surgery Based on Optical Coherence Tomography
NCT00532051
Recruiting
The long-term goal of this project is to utilize very high-speed optical coherence tomography (OCT) technology to guide surgical treatments of corneal diseases. OCT is well known for its exquisite resolution, but until recently it has not had sufficient speed to capture the shape of the cornea because of eye motion during OCT scanning. The development of Fourier-domain (FD) OCT technology has made the requisite speed possible. The objective of this project is to develop methods for imaging the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Cataract
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Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
NCT01243931
Recruiting
Optical Coherence Tomography (OCT) machines are non-contact instruments that can measure the depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this study is to determine whether OCT-guided settings for the lasers used for removal of corneal scars and other partial-thickness corneal defects result in improved vision in patients receiving these procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Corneal Opacity
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Optical Coherence Tomography (OCT) in Uveitis
NCT02026128
Recruiting
Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer (one one-thousandths) scale imaging of biological tissue. This allows excellent assessment of the white blood and inflammatory cells seen in uveitis, an inflammation of any or all parts of the uvea (iris, ciliary body, choroid).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Uveitis
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Observational Study of Corneal Opacities in Adults
NCT02109471
Recruiting
A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/08/2024
Locations: Humberto Martinez, Portland, Oregon
Conditions: Corneal Opacities (Scar and Stromal Dystrophy)
Register for Updates
OCT in Rare Chorioretinal Diseases
NCT02141308
Recruiting
This study will evaluate the total blood flow in the retina and choroid (structures in the back of the eye) by Doppler optical coherence tomography (OCT) and OCT angiography. Angiography is mapping of the blood vessels. The purpose of measuring blood flow in the retina and choroid is to 1.) determine if rare diseases in these structures causes a change in blood flow compared to healthy eyes and 2.) find out if areas of changed blood flow line up with areas of damage that appear on conventional... Read More
Gender:
ALL
Ages:
Between 7 years and 100 years
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Retinal Artery Occlusions, Polypoidal Choroidal Vasculopathy, Retinal Arterial Macroaneurysm, Juxtafoveal Telangiecasia, Central Serous Chorioretinopathy
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OCT Angiography in Wet AMD
NCT02253030
Recruiting
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) 2. evaluate patients undergoing treatment for wet AMD 3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Neovascular (Wet) Age-related Macular Degeneration (AMD)
Register for Updates
Collagen Cross-linking in Keratoconus
NCT03760432
Recruiting
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Keratoconus
Register for Updates
OCT Angiography and NRAI in Dementia
NCT03761381
Recruiting
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Alzheimer Disease, Dementia, Mild Cognitive Impairment
Register for Updates
Observational Study of Iris Tumors
NCT03809585
Recruiting
This is an observational study using OCT angiography to assist with tumor characterization in melanotic and amelanotic iris lesions. OCT angiography data from healthy eyes will be compared to eyes with various types of iris tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Iris Tumor
Register for Updates
OCT in Fuchs' Dystrophy
NCT04258787
Recruiting
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Fuchs Dystrophy, Pseudophakic Bullous Keratopathy
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Scleral Lens Fitting Using Wide-Field OCT
NCT04570020
Recruiting
The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of anterior surface disorders requiring scleral lens fittings will be considered for enrollment. For each study eye, a clinically-selected scleral lens fit will be compared against an OCT-selected lens fit. The quality of each lens fit will be determined by flourescein exam at... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Casey Eye Institute, Portland, Oregon
Conditions: Keratoconus, Irregular; Contour of Cornea
Register for Updates