There are currently 1006 clinical trials in Portland, Oregon looking for participants to engage in research studies. Trials are conducted at various facilities, including Oregon Health & Science University, Oregon Health and Science University /ID# 216891, Providence Portland Medical Center and Providence Saint Vincent Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Part II: Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia
NCT04373941
Recruiting
The Investigators propose to test the hypothesis that GCSF enhances the clinical outcome of biliary atresia in a multi-institutional Phase 2 trial to prospectively evaluate the safety and efficacy of GCSF in each of the 2 groups of newly diagnosed BA patients: KBA (i.e., Kasai-operated) or NoK (i.e., patients who did not undergo Kasai surgery). Subjects who participate in the trial will be followed for 2 years.
Gender:
ALL
Ages:
Between 14 days and 180 days
Trial Updated:
09/07/2023
Locations: Oregon Health & Science University (OHSU), Portland, Oregon
Conditions: Biliary Atresia
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A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
NCT04143659
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Healthy Women, Female Contraception
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
NCT05902520
Recruiting
The subject of this study is the adoptive transfer of selected autologous tumor infiltrating lymphocytes (TIL) after in vitro expansion for the treatment of solid tumor malignancies. The TIL selection process is based on evidence showing that CD8+ TIL which co-express both CD39 and CD103 harbor the bulk of tumor-reactivity and that the remaining CD8 TIL is mainly composed of non-tumor reactive bystander cells. All of the expanded TIL that are produced (1-40 billion are expected) will be delivere... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Providence Portland Medical Center, Portland, Oregon
Conditions: HNSCC, Melanoma, Gynecologic Cancer, Colorectal Cancer, Lung Cancer, Urogenital Cancer
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Bringing Weight Management Into the Primary Care Pediatric Practice
NCT05950620
Recruiting
This project aims to move what is currently a specialty-care model for the management of obesity of children and adolescents into the primary care setting.
Gender:
ALL
Ages:
Between 1 month and 21 years
Trial Updated:
07/17/2023
Locations: The Children's Clinic, Portland, Oregon +1 locations
Conditions: Obesity, Childhood
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Ovarian Tissue Freezing For Fertility Preservation
NCT00902720
Recruiting
The purpose of this study is to offer an alternative method to women who wish to preserve the possibility of fertility, as well as to learn more about the ability of human eggs to survive and function after long term storage in frozen ovaries (ovarian tissue cryopreservation). The study will seek to preserve ovarian tissue and reproductive potential for patients whose medical or surgical treatment may harm ovaries or remove ovarian tissue.
Gender:
FEMALE
Ages:
Between 18 years and 41 years
Trial Updated:
06/30/2023
Locations: Oregon Health and Sciences Universtiy, Portland, Oregon
Conditions: Malignancy, Fertility
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The Work-life Check-ins: a Supervisor-driven Intervention to Reduce Burnout in Primary Care
NCT05436548
Recruiting
The objective of this study is to evaluate the effectiveness and process of frequent supervisor-employee check-ins in reducing burnout among employees of primary care clinics in Portland, OR. Healthcare workers are at risk for burnout and associated adverse health and safety outcomes, including chronic diseases and occupational injuries. Not only does burnout affect healthcare workers, but burnout also affects the quality of patient care. The proposed study will create a check-in process between... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2023
Locations: OHSU, Portland, Oregon +1 locations
Conditions: Burnout
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Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma
NCT04797884
Recruiting
The primary goals of this study are to compare overall survival and quality of life in subjects with Child-Pugh A or B advanced hepatocellular carcinoma when treated with a device emitting radiofrequencies modulated at specific frequencies or with a device emitting unmodulated radiofrequencies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2023
Locations: Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon
Conditions: Hepatocellular Carcinoma
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Allogeneic NK T-Cells Expressing CD19 Specific CAR in B-Cell Malignancies
NCT05487651
Recruiting
This study is a multi-center study to evaluate the safety of KUR-502 in subjects with refractory/relapsed B-cell NHL or leukemia (ALL or CLL).
Gender:
ALL
Ages:
Between 3 years and 75 years
Trial Updated:
05/16/2023
Locations: OHSU - Knight Cancer Center, Portland, Oregon
Conditions: NHL, Relapsed, Adult, B-cell Lymphoma, B-cell Leukemia, DLBCL - Diffuse Large B Cell Lymphoma, ALL, Adult B Cell, ALL, Childhood, CLL/SLL
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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Eye Pressure Lowering Surgery
NCT01931904
Recruiting
The purpose of this study is to determine if lowering the pressure inside the eye improves blood flow to the eye.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/17/2023
Locations: OHSU, Portland, Oregon
Conditions: Glaucoma
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Functional and Structural Imaging for Glaucoma
NCT01957267
Recruiting
The specific aims of the clinical studies are to: * Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by combining structural and angiography OCT data. * Assess abilities of above technologies and OCT-derived parameters on predicting glaucoma detection, conversion, and progression.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
04/17/2023
Locations: Oregon Health & Science University, Casey Eye Institute, Portland, Oregon
Conditions: Glaucoma
Register for Updates